{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:53:13Z","timestamp":1774360393760,"version":"3.50.1"},"reference-count":59,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Grant PJT-149046"],"award-info":[{"award-number":["Grant PJT-149046"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["500865"],"award-info":[{"award-number":["500865"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-17-0018613"],"award-info":[{"award-number":["G-17-0018613"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Defective fetoplacental vascular maturation causes intrauterine growth restriction (IUGR). A transcriptional switch initiates placental maturation where blood vessels elongate. However, cellular mechanisms and regulatory pathways involved are unknown. We show that the histone methyltransferase Ehmt2, also known as G9a, activates the Notch pathway to promote placental vascular maturation. Placental vasculature from embryos with G9a-deficient endothelial progenitor cells failed to expand due to decreased endothelial cell proliferation and increased trophoblast proliferation. Moreover, G9a deficiency altered the transcriptional switch initiating placental maturation and caused downregulation of Notch pathway effectors including Rbpj. Importantly, Notch pathway activation in G9a-deficient endothelial progenitors extended embryonic life and rescued placental vascular expansion. Thus, G9a activates the Notch pathway to balance endothelial cell and trophoblast proliferation and coordinates the transcriptional switch controlling placental vascular maturation. Accordingly, G9A and RBPJ were downregulated in human placentae from IUGR-affected pregnancies, suggesting that G9a is an important regulator in placental diseases caused by defective vascular maturation.<\/jats:p>","DOI":"10.1242\/dev.148916","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T00:40:20Z","timestamp":1493426420000},"source":"Crossref","is-referenced-by-count":19,"title":["Ehmt2\/G9a controls placental vascular maturation by activating the Notch pathway"],"prefix":"10.1242","author":[{"given":"Lijun","family":"Chi","sequence":"first","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdalla","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna R.","family":"Roy","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Vuong","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay S.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"},{"name":"Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Caporiccio","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Sled","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"},{"name":"Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Caniggia","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-247X","authenticated-orcid":false,"given":"Paul","family":"Delgado-Olguin","sequence":"additional","affiliation":[{"name":"Translational Medicine, The Hospital for Sick Children, Toronto, ON, M5G0A4, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada"},{"name":"Heart & Stroke Richard Lewar Centre of Excellence, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042608525529300_DEV148916C1","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"Adamson","year":"2002","journal-title":"Dev. Biol."},{"key":"2021042608525529300_DEV148916C2","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/s0029-7844(00)00946-7","article-title":"One-stage screening for pregnancy complications by color Doppler assessment of the uterine arteries at 23 weeks\u2019 gestation","volume":"96","author":"Albaiges","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"2021042608525529300_DEV148916C3","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/01.AOG.0000429658.85846.f9","article-title":"ACOG Practice bulletin no. 134: fetal growth restriction","volume":"121","author":"American College of Obstetricians and Gynecologists","year":"2013","journal-title":"Obstet. Gynecol."},{"key":"2021042608525529300_DEV148916C4","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.earlhumdev.2009.09.004","article-title":"Distinguishing pathological from constitutional small for gestational age births in population-based studies","volume":"85","author":"Ananth","year":"2009","journal-title":"Early Hum. Dev."},{"key":"2021042608525529300_DEV148916C5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2021042608525529300_DEV148916C6","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1093\/cvr\/cvv098","article-title":"Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor beta signalling and angiogenesis","volume":"106","author":"Awwad","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"2021042608525529300_DEV148916C7","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/bmj.298.6673.564","article-title":"Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease","volume":"298","author":"Barker","year":"1989","journal-title":"BMJ"},{"key":"2021042608525529300_DEV148916C8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1387\/ijdb.082760db","article-title":"The surface area of the placenta and hypertension in the offspring in later life","volume":"54","author":"Barker","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"2021042608525529300_DEV148916C9","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1746-1596-5-24","article-title":"Intrauterine growth restriction and placental angiogenesis","volume":"5","author":"Barut","year":"2010","journal-title":"Diagn. Pathol."},{"key":"2021042608525529300_DEV148916C10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-642-23941-0_7","article-title":"Architecture of normal villous trees","author":"Benirschke","year":"2012","journal-title":"Pathology of the Human Placenta"},{"key":"2021042608525529300_DEV148916C11","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"2021042608525529300_DEV148916C12","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.gep.2013.06.003","article-title":"Expression of NOL1\/NOP2\/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis","volume":"13","author":"Chi","year":"2013","journal-title":"Gene Expr. Patterns"},{"key":"2021042608525529300_DEV148916C13","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-213X-11-12","article-title":"Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac","volume":"11","author":"Copeland","year":"2011","journal-title":"BMC Dev. Biol."},{"key":"2021042608525529300_DEV148916C14","doi-asserted-by":"publisher","first-page":"4610","DOI":"10.1242\/dev.112607","article-title":"Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature","volume":"141","author":"Delgado-Olguin","year":"2014","journal-title":"Development"},{"key":"2021042608525529300_DEV148916C15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000353633","article-title":"Long-term follow-up of intrauterine growth restriction: cardiovascular disorders","volume":"36","author":"Demicheva","year":"2014","journal-title":"Fetal Diagn. Ther."},{"key":"2021042608525529300_DEV148916C16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2021042608525529300_DEV148916C17","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1038\/mt.2015.106","article-title":"Arylsulfatase A overexpressing human iPSC-derived neural cells reduce CNS sulfatide storage in a mouse model of metachromatic leukodystrophy","volume":"23","author":"Doerr","year":"2015","journal-title":"Mol. Ther."},{"key":"2021042608525529300_DEV148916C18","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1242\/dev.093351","article-title":"Notch controls retinal blood vessel maturation and quiescence","volume":"140","author":"Ehling","year":"2013","journal-title":"Development"},{"key":"2021042608525529300_DEV148916C19","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1161\/01.RES.0000200740.57764.52","article-title":"Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction","volume":"98","author":"Galasso","year":"2006","journal-title":"Circ. Res."},{"key":"2021042608525529300_DEV148916C20","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1073\/pnas.1013751108","article-title":"The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels","volume":"108","author":"Griffin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608525529300_DEV148916C21","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"2021042608525529300_DEV148916C22","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.mod.2013.07.002","article-title":"Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis","volume":"130","author":"Inagawa","year":"2013","journal-title":"Mech. Dev."},{"key":"2021042608525529300_DEV148916C23","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1056\/NEJMoa0907328","article-title":"Valproic acid monotherapy in pregnancy and major congenital malformations","volume":"362","author":"Jentink","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"2021042608525529300_DEV148916C24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/BF00316301","article-title":"The fetal vascularisation of term human placental villi. II. Intermediate and terminal villi","volume":"173","author":"Kaufmann","year":"1985","journal-title":"Anat. Embryol."},{"key":"2021042608525529300_DEV148916C25","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1101\/gr.071407.107","article-title":"Genomic evolution of the placenta using co-option and duplication and divergence","volume":"18","author":"Knox","year":"2008","journal-title":"Genome Res."},{"key":"2021042608525529300_DEV148916C26","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2021042608525529300_DEV148916C27","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0925-4773(02)00332-5","article-title":"Role of endothelial cells in early pancreas and liver development","volume":"120","author":"Lammert","year":"2003","journal-title":"Mech. Dev."},{"key":"2021042608525529300_DEV148916C28","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1242\/jcs.00969","article-title":"The bHLH TAL-1\/SCL regulates endothelial cell migration and morphogenesis","volume":"117","author":"Lazrak","year":"2004","journal-title":"J. Cell Sci."},{"key":"2021042608525529300_DEV148916C29","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1242\/dev.003244","article-title":"Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis","volume":"134","author":"Leslie","year":"2007","journal-title":"Development"},{"key":"2021042608525529300_DEV148916C30","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2021042608525529300_DEV148916C31","first-page":"925","article-title":"Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14","volume":"8","author":"Maglione","year":"1993","journal-title":"Oncogene"},{"key":"2021042608525529300_DEV148916C32","doi-asserted-by":"publisher","first-page":"14920","DOI":"10.1073\/pnas.2436557100","article-title":"Notch signaling controls multiple steps of pancreatic differentiation","volume":"100","author":"Murtaugh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608525529300_DEV148916C33","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"2021042608525529300_DEV148916C34","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1126\/science.1163802","article-title":"The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin","volume":"322","author":"Nagano","year":"2008","journal-title":"Science"},{"key":"2021042608525529300_DEV148916C35","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/nature05355","article-title":"Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis","volume":"444","author":"Noguera-Troise","year":"2006","journal-title":"Nature"},{"key":"2021042608525529300_DEV148916C36","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.febslet.2014.01.039","article-title":"H3K9 histone methyltransferase G9a-mediated transcriptional activation of p21","volume":"588","author":"Oh","year":"2014","journal-title":"FEBS Lett."},{"key":"2021042608525529300_DEV148916C37","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1161\/ATVBAHA.114.304741","article-title":"Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4\/Notch1","volume":"35","author":"Pedrosa","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021042608525529300_DEV148916C38","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/cncr.25652","article-title":"Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method","volume":"117","author":"Pinchot","year":"2011","journal-title":"Cancer"},{"key":"2021042608525529300_DEV148916C39","doi-asserted-by":"publisher","first-page":"9940","DOI":"10.1523\/JNEUROSCI.3467-05.2005","article-title":"Vascular development of the brain requires beta8 integrin expression in the neuroepithelium","volume":"25","author":"Proctor","year":"2005","journal-title":"J. Neurosci."},{"key":"2021042608525529300_DEV148916C40","doi-asserted-by":"publisher","first-page":"41963","DOI":"10.1074\/jbc.M111.298463","article-title":"A distinct mechanism for coactivator versus corepressor function by histone methyltransferase G9a in transcriptional regulation","volume":"286","author":"Purcell","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2021042608525529300_DEV148916C41","doi-asserted-by":"publisher","first-page":"H675","DOI":"10.1152\/ajpheart.00510.2010","article-title":"Vessel tortuousity and reduced vascularization in the fetoplacental arterial tree after maternal exposure to polycyclic aromatic hydrocarbons","volume":"300","author":"Rennie","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021042608525529300_DEV148916C42","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/B978-0-12-394445-0.00055-2","article-title":"Scanning electron microscopy and micro-computed tomography imaging of the utero- and fetoplacental circulations","volume-title":"The Guide to Investigation of Mouse Pregnancy","author":"Rennie","year":"2014"},{"key":"2021042608525529300_DEV148916C43","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1095\/biolreprod.114.123968","article-title":"Site-specific increases in utero- and fetoplacental arterial vascular resistance in eNOS-deficient mice due to impaired arterial enlargement","volume":"92","author":"Rennie","year":"2015","journal-title":"Biol. Reprod."},{"key":"2021042608525529300_DEV148916C44","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nature05313","article-title":"Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis","volume":"444","author":"Ridgway","year":"2006","journal-title":"Nature"},{"key":"2021042608525529300_DEV148916C45","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1101\/gad.1589207","article-title":"Regulation of vascular morphogenesis by Notch signaling","volume":"21","author":"Roca","year":"2007","journal-title":"Genes Dev."},{"key":"2021042608525529300_DEV148916C46","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.acthis.2009.10.006","article-title":"Distribution of Notch family proteins in intrauterine growth restriction and hypertension complicated human term placentas","volume":"113","author":"Sahin","year":"2011","journal-title":"Acta Histochem."},{"key":"2021042608525529300_DEV148916C47","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","article-title":"Java Treeview\u2013extensible visualization of microarray data","volume":"20","author":"Saldanha","year":"2004","journal-title":"Bioinformatics"},{"key":"2021042608525529300_DEV148916C48","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.molcel.2007.06.026","article-title":"Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly","volume":"27","author":"Sampath","year":"2007","journal-title":"Mol. Cell"},{"key":"2021042608525529300_DEV148916C49","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1161\/01.RES.0000253975.76198.ff","article-title":"Antiangiogenic activity of the MDM2 antagonist nutlin-3","volume":"100","author":"Secchiero","year":"2007","journal-title":"Circ. Res."},{"key":"2021042608525529300_DEV148916C50","doi-asserted-by":"publisher","first-page":"e1000073","DOI":"10.1371\/journal.pgen.1000073","article-title":"HOXA13 is essential for placental vascular patterning and labyrinth endothelial specification","volume":"4","author":"Shaut","year":"2008","journal-title":"PLoS Genet."},{"key":"2021042608525529300_DEV148916C51","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1101\/gad.2027411","article-title":"H3K9 methyltransferase G9a and the related molecule GLP","volume":"25","author":"Shinkai","year":"2011","journal-title":"Genes Dev."},{"key":"2021042608525529300_DEV148916C52","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/nature05577","article-title":"Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries","volume":"445","author":"Siekmann","year":"2007","journal-title":"Nature"},{"key":"2021042608525529300_DEV148916C53","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608525529300_DEV148916C54","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1101\/gad.989402","article-title":"G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis","volume":"16","author":"Tachibana","year":"2002","journal-title":"Genes Dev."},{"key":"2021042608525529300_DEV148916C55","doi-asserted-by":"publisher","first-page":"e12167","DOI":"10.7554\/elife.12167","article-title":"Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion","volume":"5","author":"Ubezio","year":"2016","journal-title":"Elife"},{"key":"2021042608525529300_DEV148916C56","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/ncomms1668","article-title":"Spatial coordination between cell and nuclear shape within micropatterned endothelial cells","volume":"3","author":"Versaevel","year":"2012","journal-title":"Nat. Commun."},{"key":"2021042608525529300_DEV148916C57","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1128\/MCB.01111-07","article-title":"G9a histone methyltransferase contributes to imprinting in the mouse placenta","volume":"28","author":"Wagschal","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"2021042608525529300_DEV148916C58","first-page":"371","article-title":"Vascular corrosion casting of the uteroplacental and fetoplacental vasculature in mice","volume":"121","author":"Whiteley","year":"2006","journal-title":"Methods Mol. Med."},{"key":"2021042608525529300_DEV148916C59","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0020-7292(99)00226-X","article-title":"Prenatal detection of a high-risk group for intrauterine growth restriction based on sonographic fetal biometry","volume":"68","author":"Yoshida","year":"2000","journal-title":"Int. J. Gynaecol. Obstet."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.148916","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/144\/11\/1976\/1847381\/dev148916.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.148916\/2053334\/dev_148916v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.148916\/2053334\/dev_148916v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T17:06:06Z","timestamp":1621357566000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/doi\/10.1242\/dev.148916\/264313\/Ehmt2-G9a-controls-placental-vascular-maturation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":59,"URL":"https:\/\/doi.org\/10.1242\/dev.148916","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,1]]},"article-number":"dev.148916"}}