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All placodes arise from a horseshoe-shaped preplacodal ectoderm in which the precursors of individual placodes are intermingled. However, fate-map studies indicated that cells positioned at the preplacodal midline give rise to only the adenohypophyseal placode, suggesting a unique organization of these precursors within the preplacode. To test this possibility, we combined embryological and molecular approaches in chick embryos to show that, at gastrula stage, adenohypophyseal precursors are clustered in the median preplacodal ectoderm, largely segregated from those of the adjacent olfactory placode. Median precursors are elongated, densely packed and, at neurula stage, express a molecular signature that distinguishes them from the remaining preplacodal cells. Olfactory placode precursors and midline neural cells can replace ablated adenohypophyseal precursors up to head-fold stage, although with a more plastic organization. We thus propose that adenohypophyseal placode precursors are unique within the preplacodal ectoderm possibly because they originate the only single placode and the only one with an endocrine character.<\/jats:p>","DOI":"10.1242\/dev.149724","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T11:25:19Z","timestamp":1507029919000},"page":"3521-3532","source":"Crossref","is-referenced-by-count":7,"title":["Adenohypophysis placodal precursors exhibit distinctive features within the rostral preplacodal ectoderm"],"prefix":"10.1242","volume":"144","author":[{"given":"Luisa","family":"Sanchez-Arrones","sequence":"first","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC-UAM, c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"},{"name":"CIBER de Enfermedades Raras (CIBERER), c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1frica","family":"Sandon\u00eds","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC-UAM, c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"},{"name":"CIBER de Enfermedades Raras (CIBERER), c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Juli\u00e1n","family":"Cardozo","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC-UAM, c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"},{"name":"CIBER de Enfermedades Raras (CIBERER), c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-751X","authenticated-orcid":false,"given":"Paola","family":"Bovolenta","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC-UAM, c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"},{"name":"CIBER de Enfermedades Raras (CIBERER), c\/ Nicol\u00e1s Cabrera 1, Madrid 28049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042609021505200_DEV149724C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000079035","article-title":"Molecular basis of pituitary development and cytogenesis","volume":"32","author":"Asa","year":"2004","journal-title":"Front. 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