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Integrins, are heterodimeric transmembrane receptors consisting of \u03b1 and \u03b2 subunits and critical integrins in the kidney collecting system express the \u03b21subunit. The \u03b21 cytoplasmic tail has two NPxY motifs that mediate functions by binding to cytoplasmic signaling and scaffolding molecules. Talins, scaffolding proteins that bind to the membrane proximal NPxY motif, are proposed to activate integrins and link them to the actin cytoskeleton. We defined the role of talin binding to the \u03b21 proximal NPxY motif in the developing kidney collecting system in mice that selectively express a Y-to-A mutation in this motif. The mice developed a hypoplastic dysplastic collecting system. Collecting duct cells expressing this mutation had moderate abnormalities in cell adhesion, migration, proliferation and growth factor dependent signaling. In contrast, mice lacking talins in the developing ureteric bud developed kidney agenesis and collecting duct cells had severe cytoskeletal, adhesion and polarity defects. Thus, talins are essential for kidney collecting duct development through mechanisms that extend beyond those requiring binding to the \u03b21 integrin subunit NPxY motif.<\/jats:p>","DOI":"10.1242\/dev.149914","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:10:32Z","timestamp":1507594232000},"source":"Crossref","is-referenced-by-count":7,"title":["Talin regulates integrin \u03b21 dependent and independent cell functions in ureteric bud development"],"prefix":"10.1242","author":[{"given":"Sijo","family":"Mathew","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya J.","family":"Palamuttam","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Mernaugh","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Ramalingam","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Center for Structure Biology, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Department of Molecular Physiology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuta","family":"Ishibe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Critchley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"F\u00e4ssler","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Department of Molecular Physiology, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Veteran Affairs Hospital Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-2602","authenticated-orcid":false,"given":"Charles R.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Center for Structure Biology, Vanderbilt University Medical Center, Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2983-8133","authenticated-orcid":false,"given":"Roy","family":"Zent","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, USA"},{"name":"Veteran Affairs Hospital Nashville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042609040303800_DEV149914C1","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1242\/jcs.052704","article-title":"Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions","volume":"122","author":"Albiges-Rizo","year":"2009","journal-title":"J. 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