{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:42:15Z","timestamp":1790487735117,"version":"4.1.0"},"reference-count":53,"publisher":"The Company of Biologists","issue":"20","license":[{"start":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:00:00Z","timestamp":1523750400000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health","award":["2R01-DK062027"],"award-info":[{"award-number":["2R01-DK062027"]}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health","award":["R01DK099722"],"award-info":[{"award-number":["R01DK099722"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:p>The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1, Ad4bp) is crucial for formation, development and function of steroidogenic tissues. A fetal adrenal enhancer (FAdE) in the Sf1 gene was previously identified to direct Sf1 expression exclusively in the fetal adrenal cortex and is bound by both Sf1 and Dax1. Here, we have examined the function of Sf1 SUMOylation and its interaction with Dax1 on FAdE function. A diffused prolonged pattern of FAdE expression and delayed regression of the postnatal fetal cortex (X-zone) were detected in both the SUMOylation-deficient-Sf12KR\/2KR and Dax1 knockout mouse lines, with FAdE expression\/activity retained in the postnatal 20\u03b1HSD-positive postnatal X-zone cells. In vitro studies indicated that Sf1 SUMOylation, although not directly influencing DNA binding, actually increased binding of Dax1 to Sf1 to further enhance transcriptional repression of FAdE. Taken together, these studies define a crucial repressor function of Sf1 SUMOylation and Dax1 in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone).<\/jats:p>","DOI":"10.1242\/dev.150516","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:11:01Z","timestamp":1505175061000},"page":"3798-3807","source":"Crossref","is-referenced-by-count":28,"title":["Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1"],"prefix":"10.1242","volume":"144","author":[{"given":"Yewei","family":"Xing","sequence":"first","affiliation":[{"name":"University of Michigan Health System 1 Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes , , Ann Arbor, MI 48109-2200 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichirou","family":"Morohashi","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Kyushu University 2 Department of Molecular Biology , , Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"Ingraham","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California 3 Department of Cellular Molecular Pharmacology , , San Francisco, CA 94158 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-3628","authenticated-orcid":false,"given":"Gary D.","family":"Hammer","sequence":"additional","affiliation":[{"name":"University of Michigan Health System 1 Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes , , Ann Arbor, MI 48109-2200 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061215580234400_DEV150516C1","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1002\/biot.200900219","article-title":"SUMOylation and cell signalling","volume":"4","author":"Andreou","year":"2009","journal-title":"Biotechnol. 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