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In this study, we show that tight regulation of endogenous PDGFR\u03b1 activity is required for normal calvarium development in the mouse and that deregulated PDGFR\u03b1 activity causes craniosynostosis. Constitutive activation of PDGFR\u03b1 leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K\/Akt signaling. Our results thus identify a novel mechanism underlying calvarial development in craniosynostosis.<\/jats:p>","DOI":"10.1242\/dev.151068","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:40:27Z","timestamp":1506386427000},"source":"Crossref","is-referenced-by-count":13,"title":["Deregulated PDGFR\u03b1 signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification"],"prefix":"10.1242","author":[{"given":"Fenglei","family":"He","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-926X","authenticated-orcid":false,"given":"Philippe","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042609023567200_DEV151068C1","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev."},{"key":"2021042609023567200_DEV151068C2","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"2021042609023567200_DEV151068C3","volume-title":"Craniosynostosis. 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