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Here, using a novel temperature-sensitive (ts) allele, we show that the phosphoinositide phosphatase Sac1 is also required for IOC patterning. Sac1ts mutants have rough eyes and retinal patterning defects that resemble rst mutants. Sac1ts retinas exhibit elevated levels of phosphatidylinositol 4-phosphate (PI4P), consistent with the role of Sac1 as a PI4P phosphatase. Indeed, genetic rescue and interaction experiments reveal that restriction of PI4P levels by Sac1 is crucial for normal eye development. Rst is delivered to the cell surface in Sac1ts mutants. However, Sac1ts mutant IOCs exhibit severe defects in microtubule organization, associated with accumulation of Rst and the exocyst subunit Sec8 in enlarged intracellular vesicles upon cold fixation ex vivo. Together, our data reveal a novel requirement for Sac1 in promoting microtubule stability and suggest that Rst trafficking occurs in a microtubule- and exocyst-dependent manner.<\/jats:p>","DOI":"10.1242\/dev.151571","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T09:10:19Z","timestamp":1526029819000},"source":"Crossref","is-referenced-by-count":9,"title":["The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing <i>Drosophila<\/i> eye"],"prefix":"10.1242","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-0551","authenticated-orcid":false,"given":"Lauren M.","family":"Del Bel","sequence":"first","affiliation":[{"name":"Cell Biology Program, The Hospital for Sick Children 1 , PGCRL Building, 686 Bay Street, Toronto, Ontario, M5G 0A4 , Canada"},{"name":"University of Toronto 2 Department of Molecular Genetics , , 1 King's College Circle, Toronto, Ontario, M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Cell Biology Program, The Hospital for Sick Children 1 , PGCRL Building, 686 Bay Street, Toronto, Ontario, M5G 0A4 , Canada"},{"name":"University of Toronto 2 Department of Molecular Genetics , , 1 King's College Circle, Toronto, Ontario, M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0982-313X","authenticated-orcid":false,"given":"Ronit","family":"Wilk","sequence":"additional","affiliation":[{"name":"Cell Biology Program, The Hospital for Sick Children 1 , PGCRL Building, 686 Bay Street, Toronto, Ontario, M5G 0A4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-0273","authenticated-orcid":false,"given":"Ho-Chun","family":"Wei","sequence":"additional","affiliation":[{"name":"Cell Biology Program, The Hospital for Sick Children 1 , PGCRL Building, 686 Bay Street, Toronto, Ontario, M5G 0A4 , Canada"},{"name":"Simon Fraser University, South Sciences Building Room 8166, 8888 University Drive, Burnaby, British Columbia, V5A 1S6, Canada 3 Department of Molecular Biology and Biochemistry ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-7406","authenticated-orcid":false,"given":"Anastasia","family":"Blagoveshchenskaya","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University 4 Division of Nephrology & Hypertension , , 3181 S.W. Sam Jackson Park Rd., Portland, Oregon 97239-3098 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-3506","authenticated-orcid":false,"given":"Jason","family":"Burgess","sequence":"additional","affiliation":[{"name":"Cell Biology Program, The Hospital for Sick Children 1 , PGCRL Building, 686 Bay Street, Toronto, Ontario, M5G 0A4 , Canada"},{"name":"University of Toronto 2 Department of Molecular Genetics , , 1 King's College Circle, Toronto, Ontario, M5S 1A8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-6303","authenticated-orcid":false,"given":"Gordon","family":"Polevoy","sequence":"additional","affiliation":[{"name":"Cell Biology Program, The Hospital for Sick Children 1 , PGCRL Building, 686 Bay Street, Toronto, Ontario, M5G 0A4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-7317","authenticated-orcid":false,"given":"James V.","family":"Price","sequence":"additional","affiliation":[{"name":"Simon Fraser University, South Sciences Building Room 8166, 8888 University Drive, Burnaby, British Columbia, V5A 1S6, Canada 3 Department of Molecular Biology and Biochemistry ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1318-3339","authenticated-orcid":false,"given":"Peter","family":"Mayinger","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University 4 Division of Nephrology & Hypertension , , 3181 S.W. 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