{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:21:26Z","timestamp":1780759286034,"version":"3.54.1"},"reference-count":74,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE018405, K99DE026239"],"award-info":[{"award-number":["DE018405, K99DE026239"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R00NS080913"],"award-info":[{"award-number":["R00NS080913"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002112","name":"A.P. 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Here we use combinatorial labeling of zebrafish cranial neural crest-derived cells (CNCCs) to define global gene expression along the dorsoventral axis of the developing arches. Intersection of region-specific transcriptomes with expression changes in response to signaling perturbations demonstrates complex roles for Endothelin 1 (Edn1) signaling in the intermediate joint-forming region, yet a surprisingly minor role in ventralmost regions. Analysis of co-variance across multiple sequencing experiments further reveals clusters of co-regulated genes, with in situ hybridization confirming the domain-specific expression of novel genes. We then created loss-of-function alleles for 12 genes and uncovered antagonistic functions of two new Edn1 targets, follistatin a (fsta) and emx2, in regulating cartilaginous joints in the hyoid arch. Our unbiased discovery and functional analysis of genes with regional expression in zebrafish arch CNCCs reveals complex regulation by Edn1 and points to novel candidates for craniofacial disorders.<\/jats:p>","DOI":"10.1242\/dev.151712","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T20:10:48Z","timestamp":1499976648000},"page":"2994-3005","source":"Crossref","is-referenced-by-count":57,"title":["Genome-wide analysis of facial skeletal regionalization in zebrafish"],"prefix":"10.1242","volume":"144","author":[{"given":"Amjad","family":"Askary","sequence":"first","affiliation":[{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Barske","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Bay","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bump","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Balczerski","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Bonaguidi","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-0026","authenticated-orcid":false,"given":"J. 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