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We used both morphological assessments of cellular rearrangements and time-lapse imaging to visualize cochlear remodeling in mouse. Analysis of cell redistribution showed that the cochlea extends through a combination of radial intercalation and cell growth. Live imaging demonstrated that concomitant cellular intercalation results in a brief period of epithelial convergence, although subsequent changes in cell size lead to medial-lateral spreading. Supporting cells, which retain contact with the basement membrane, exhibit biased protrusive activity and directed movement along the axis of extension. By contrast, hair cells lose contact with the basement membrane, but contribute to continued outgrowth through increased cell size. Regulation of cellular protrusions, movement and intercalation within the cochlea all require myosin II. These results establish, for the first time, many of the cellular processes that drive the distribution of sensory cells along the tonotopic axis of the cochlea.<\/jats:p>","DOI":"10.1242\/dev.151761","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:25:33Z","timestamp":1504571133000},"page":"3766-3776","source":"Crossref","is-referenced-by-count":50,"title":["Cell migration, intercalation and growth regulate mammalian cochlear extension"],"prefix":"10.1242","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-1053","authenticated-orcid":false,"given":"Elizabeth Carroll","family":"Driver","sequence":"first","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH Laboratory \u2008 of \u2008 Cochlear Development , , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Northrop","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH Laboratory \u2008 of \u2008 Cochlear Development , , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Kelley","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH Laboratory \u2008 of \u2008 Cochlear Development , , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061215580339100_DEV151761C1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-1-4939-6371-3_13","article-title":"Segmentation and quantitative analysis of epithelial tissues","volume":"1478","author":"Aigouy","year":"2016","journal-title":"Methods Mol. 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