{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:19:37Z","timestamp":1789597177530,"version":"build-2803163510"},"reference-count":31,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP160103100"],"award-info":[{"award-number":["DP160103100"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP130100886"],"award-info":[{"award-number":["DP130100886"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT100100620"],"award-info":[{"award-number":["FT100100620"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1106516"],"award-info":[{"award-number":["APP1106516"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Metanephric kidney development is orchestrated by the iterative branching morphogenesis of the ureteric bud. We describe an underlying patterning associated with the ramification of this structure and show that this pattern is conserved between developing kidneys, in different parts of the organ and across developmental time. This regularity is associated with a highly reproducible branching asymmetry that is consistent with locally operative growth mechanisms. We then develop a class of tip state models to represent elaboration of the ureteric tree and describe rules for \u201chalf delay\u201d branching morphogenesis that describe almost perfectly the patterning of this structure. Spatial analysis suggests that the observed asymmetry may arise from mutual suppression of bifurcation, but not extension, between the growing ureteric tips and demonstrate that disruption of patterning occurs in mouse mutants in which the distribution of tips on the surface of the kidney is altered. These findings demonstrate that kidney development occurs by way of highly conserved reiterative pattern of asymmetric bifurcation governed by intrinsic and locally operative mechanisms.<\/jats:p>","DOI":"10.1242\/dev.153874","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T20:25:31Z","timestamp":1508185531000},"source":"Crossref","is-referenced-by-count":24,"title":["Branching morphogenesis in the developing kidney is governed by rules that pattern the ureteric tree"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-9575","authenticated-orcid":false,"given":"James","family":"Lefevre","sequence":"first","affiliation":[{"name":"Division of Genomics & Development of Disease , Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-008X","authenticated-orcid":false,"given":"Kieran M.","family":"Short","sequence":"additional","affiliation":[{"name":"Monash Biomedical Research Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia"},{"name":"Department of Anatomy and Developmental Biology, Monash University, Clayton, Melbourne, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy O.","family":"Lamberton","sequence":"additional","affiliation":[{"name":"Division of Genomics & Development of Disease , Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-4315","authenticated-orcid":false,"given":"Odyss\u00e9","family":"Michos","sequence":"additional","affiliation":[{"name":"Department of Biosystems, Science and Engineering (D-BSSE), ETH Zurich, Basel 4058, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-8117","authenticated-orcid":false,"given":"Daniel","family":"Graf","sequence":"additional","affiliation":[{"name":"School of Dentistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta T6G 1C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-7829","authenticated-orcid":false,"given":"Ian M.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Monash Biomedical Research Institute, Monash University, Clayton, Melbourne, Victoria 3800, Australia"},{"name":"Department of Anatomy and Developmental Biology, Monash University, Clayton, Melbourne, Victoria 3800, Australia"},{"name":"Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0331-3427","authenticated-orcid":false,"given":"Nicholas A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Division of Genomics & Development of Disease , Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042512194987100_DEV153874C1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.devcel.2004.12.004","article-title":"Sprouty1 is a critical regulator of GDNF\/RET-mediated kidney induction","volume":"8","author":"Basson","year":"2005","journal-title":"Dev. 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