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ACG1A is surprisingly tissue specific, mainly affecting cartilage development. Bone development is also abnormal, but as chondrogenesis and osteogenesis are closely coupled, this could be a secondary consequence of the cartilage defect. A possible explanation for the tissue specificity of ACG1A is that cartilage and bone are highly secretory tissues with a high use of the membrane trafficking machinery. The perinatal lethality of ACG1A prevents investigating this hypothesis. We therefore generated mice with conditional Trip11 knockout alleles and inactivated Trip11 in chondrocytes, osteoblasts, osteoclasts and pancreas acinar cells, all highly secretory cell types. We discovered that the ACG1A skeletal phenotype is solely due to absence of GMAP-210 in chondrocytes. Mice lacking GMAP-210 in osteoblasts, osteoclasts and acinar cells were normal. When we inactivated Trip11 in primary chondrocyte cultures, GMAP-210 deficiency affected trafficking of a subset of chondrocyte-expressed proteins rather than globally impairing membrane trafficking. Thus, GMAP-210 is essential for trafficking specific cargoes in chondrocytes but is dispensable in other highly secretory cells.<\/jats:p>","DOI":"10.1242\/dev.156588","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T01:10:28Z","timestamp":1511831428000},"source":"Crossref","is-referenced-by-count":19,"title":["The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects"],"prefix":"10.1242","volume":"145","author":[{"given":"Ian M.","family":"Bird","sequence":"first","affiliation":[{"name":"Orthopaedic Research Laboratories 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"},{"name":"Boston Children's Hospital 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Laboratories 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"},{"name":"Boston Children's Hospital 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin K.","family":"Schweppe","sequence":"additional","affiliation":[{"name":"Harvard Medical School 2 Department of Cell Biology , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Caetano-Lopes","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Laboratories 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"},{"name":"Boston Children's Hospital 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Robling","sequence":"additional","affiliation":[{"name":"Indiana University 3 Department of Anatomy and Cell Biology , , Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia F.","family":"Charles","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital 4 Department of Medicine , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Gygi","sequence":"additional","affiliation":[{"name":"Harvard Medical School 2 Department of Cell Biology , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Warman","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Laboratories 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"},{"name":"Boston Children's Hospital 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"},{"name":"Howard Hughes Medical Institute, Boston Children's Hospital 5 , Boston, MA 02115, USA"},{"name":"Harvard Medical School 6 Department of Genetics , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-6730","authenticated-orcid":false,"given":"Patrick J.","family":"Smits","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Laboratories 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"},{"name":"Boston Children's Hospital 1 , Department of Orthopaedic Surgery , , Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"2024061216115143700_DEV156588C1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1164\/rccm.200209-1062ST","article-title":"Mechanisms and limits of induced postnatal lung growth","volume":"170","author":"American Thoracic Society","year":"2004","journal-title":"Am. 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