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Here we show that as cell specification progresses, neuromesodermal progenitors and their progeny undergo significant changes in shape prior to their incorporation into the NT. The caudorostral progression towards differentiation is coupled to a gradual reliance on a unique combination of complex mechanisms that drive tissue folding, involving pulses of apical actomyosin contraction and planar polarised cell rearrangements, all of which are regulated by the Wnt-PCP pathway. Indeed, when this pathway is disrupted, either chemically or genetically, the polarization and morphology of cells within the entire caudal NP is disturbed, producing delays in NT closure. Indeed, the most severe disruptions of this pathway prevent caudal NT closure and result in spina bifida. In addition, a decrease in Vangl2 gene dosage also appears to promote more rapid progression towards a neural fate, but not the specification of more neural cells.<\/jats:p>","DOI":"10.1242\/dev.157487","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T09:25:14Z","timestamp":1523352314000},"source":"Crossref","is-referenced-by-count":19,"title":["The non-canonical Wnt-PCP pathway shapes the caudal neural plate"],"prefix":"10.1242","author":[{"given":"Beatriz","family":"L\u00f3pez-Escobar","sequence":"first","affiliation":[{"name":"Grupo de Neurodesarrollo, Hospital Universitario Virgen del Rocio\/Instituto de Biomedicina de Sevilla (IBIS)\/CSIC\/Universidad de Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Caro-Vega","sequence":"additional","affiliation":[{"name":"Grupo de Neurodesarrollo, Hospital Universitario Virgen del Rocio\/Instituto de Biomedicina de Sevilla (IBIS)\/CSIC\/Universidad de Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthi S.","family":"Vijayraghavan","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy F.","family":"Plageman","sequence":"additional","affiliation":[{"name":"College of Optometry, the Ohio State University, Columbus OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Sanchez-Alcazar","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD), and CIBERER. 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