{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:08:36Z","timestamp":1791616116092,"version":"4.3.4"},"reference-count":53,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100007130","name":"University of Texas System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130129"],"award-info":[{"award-number":["R01HL130129"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The entire lung epithelium arises from SRY box\u00a09 (SOX9)-expressing progenitors that form the respiratory tree and differentiate into airway and alveolar cells. Despite progress in understanding their initial specification within the embryonic foregut, how these progenitors are subsequently maintained is less clear. Using inducible, progenitor-specific genetic mosaic mouse models, we showed that \u03b2-catenin (CTNNB1) maintains lung progenitors by promoting a hierarchical lung progenitor gene signature, suppressing gastrointestinal (GI) genes, and regulating NK2 homeobox\u00a01 (NKX2.1) and SRY box\u00a02 (SOX2) in a developmental stage-dependent manner. At the early, but not later, stage post-lung specification, CTNNB1 cell-autonomously maintained normal NKX2.1 expression levels and suppressed ectopic SOX2 expression. Genetic epistasis analyses revealed that CTNNB1 is required for fibroblast growth factor (Fgf)\/Kirsten rat sarcoma viral oncogene homolog (Kras)-mediated promotion of the progenitors. In silico screening of Eurexpress and translating ribosome affinity purification (TRAP)-RNAseq identified a progenitor gene signature, a subset of which depends on CTNNB1. Wnt signaling also maintained NKX2.1 expression and suppressed GI genes in cultured human lung progenitors derived from embryonic stem cells.<\/jats:p>","DOI":"10.1242\/dev.160788","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T01:10:55Z","timestamp":1518570655000},"source":"Crossref","is-referenced-by-count":59,"title":["\u03b2-Catenin maintains lung epithelial progenitors after lung specification"],"prefix":"10.1242","volume":"145","author":[{"given":"Edwin J.","family":"Ostrin","sequence":"first","affiliation":[{"name":"the University of Texas MD Anderson Cancer Center 1 Department of Pulmonary Medicine , , Houston, Texas 77030 , USA"},{"name":"the University of Texas MD Anderson Cancer Center 2 Department of General Internal Medicine , , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle R.","family":"Little","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences 3 , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamryn N.","family":"Gerner-Mauro","sequence":"additional","affiliation":[{"name":"the University of Texas MD Anderson Cancer Center 1 Department of Pulmonary Medicine , , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Sumner","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences 3 , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"R\u00edos-Corzo","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Tecnol\u00f3gico de Monterrey 4 , Monterrey, Nuevo Le\u00f3n 64849 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"School of Engineering and Sciences, Tecnol\u00f3gico de Monterrey 5 , Monterrey, Nuevo Le\u00f3n 64849 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-3209","authenticated-orcid":false,"given":"Samantha E.","family":"Holt","sequence":"additional","affiliation":[{"name":"the University of Texas MD Anderson Cancer Center 6 Department of Clinical Cancer Prevention , , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Forcioli-Conti","sequence":"additional","affiliation":[{"name":"Center for Stem Cell and Regenerative Medicine, Brown Foundation Institute of Molecular Medicine, the University of Texas Health Science Center at Houston 7 , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Kyoto University 8 Department of Orthopedics , , Sakyo, Kyoto 606-8507 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam M.","family":"Hanash","sequence":"additional","affiliation":[{"name":"the University of Texas MD Anderson Cancer Center 6 Department of Clinical Cancer Prevention , , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shioko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism, National Cancer Institute, National Institutes of Health 9 , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah X. 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