{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:22:54Z","timestamp":1792156974369,"version":"4.4.0"},"reference-count":130,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC000059"],"award-info":[{"award-number":["DC000059"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the primary structure for the perception of sound. Along the length of the cochlear spiral is the organ of Corti, a highly derived and rigorously patterned sensory epithelium that acts to convert auditory stimuli into neural impulses. The development of the organ of Corti requires a series of inductive events that specify unique cellular characteristics and axial identities along its three major axes. Here, we review recent studies of the cellular and molecular processes regulating several aspects of cochlear development, such as axial patterning, cochlear outgrowth and cellular differentiation. We highlight how the precise coordination of multiple signaling pathways is required for the successful formation of a complete organ of Corti.<\/jats:p>","DOI":"10.1242\/dev.162263","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T16:35:11Z","timestamp":1592843711000},"source":"Crossref","is-referenced-by-count":147,"title":["Development of the cochlea"],"prefix":"10.1242","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-1053","authenticated-orcid":false,"given":"Elizabeth Carroll","family":"Driver","sequence":"first","affiliation":[{"name":"Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-1666","authenticated-orcid":false,"given":"Matthew W.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"2021042623441169600_DEV162263C1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.devcel.2011.12.006","article-title":"Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2","volume":"22","author":"Ahmed","year":"2012","journal-title":"Dev. 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