{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:31Z","timestamp":1790899231483,"version":"4.1.0"},"reference-count":26,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP106958"],"award-info":[{"award-number":["APP106958"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["BB\/J00930X\/1"],"award-info":[{"award-number":["BB\/J00930X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The adrenal medulla is composed of neuroendocrine chromaffin cells that secrete adrenaline into the systemic circulation to maintain physiological homeostasis and enable the autonomic stress response. How chromaffin cell precursors colonise the adrenal medulla, and how they become connected to central nervous system derived preganglionic sympathetic neurons remains largely unknown. By combining lineage tracing, gene expression studies, genetic ablation and the analysis of mouse mutants, we demonstrate that preganglionic axons direct chromaffin cell precursors into the adrenal primordia. We further show that preganglionic axons and chromaffin cell precursors require class 3 semaphorin (SEMA3) signalling through neuropilins (NRP) to target the adrenal medulla. Thus, SEMA3s serve as guidance cues to control formation of the adrenal neuroendocrine system by establishing appropriate connections between preganglionic neurons and adrenal chromaffin cells that regulate the autonomic stress response.<\/jats:p>","DOI":"10.1242\/dev.162552","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T05:05:24Z","timestamp":1537419924000},"source":"Crossref","is-referenced-by-count":30,"title":["Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla"],"prefix":"10.1242","author":[{"given":"Rachael","family":"Lumb","sequence":"first","affiliation":[{"name":"Centre for Cancer Biology, SA Pathology and University of South Australia, Frome Road, Adelaide, 5000, Australia"},{"name":"Medical School, University of Adelaide, Frome Road, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Tata","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, 11-43 Bath St, London EC1V 9EL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Xu","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, SA Pathology and University of South Australia, Frome Road, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Joyce","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, 11-43 Bath St, London EC1V 9EL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceilidh","family":"Marchant","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, SA Pathology and University of South Australia, Frome Road, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Harvey","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, SA Pathology and University of South Australia, Frome Road, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Ruhrberg","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology, University College London, 11-43 Bath St, London EC1V 9EL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-4181","authenticated-orcid":false,"given":"Quenten","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, SA Pathology and University of South Australia, Frome Road, Adelaide, 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2021042609160091400_DEV162552C1","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1523\/JNEUROSCI.08-05-01767.1988","article-title":"The intermediolateral cell column of the thoracic spinal cord is comprised of target-specific subnuclei: evidence from retrograde transport studies and immunohistochemistry","volume":"8","author":"Appel","year":"1988","journal-title":"J. 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