{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:45:45Z","timestamp":1790678745704,"version":"4.1.0"},"reference-count":63,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["EXC294 BIOSS"],"award-info":[{"award-number":["EXC294 BIOSS"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Neuroendocrine cells in the pineal gland release melatonin during the night and in teleosts are directly photoreceptive. During development of the pineal complex, a small number of cells migrate leftward away from the pineal anlage to form the parapineal cell cluster, a process which is crucial for asymmetrical development of the bilateral habenular nuclei. Here we show that, throughout zebrafish embryonic development, the brain-specific homeobox (bsx) gene is expressed in all cell types of the pineal complex. We identified Bmp and Noto\/Flh as major regulators of bsx expression in the pineal complex. Upon loss of Bsx through the generation of a targeted mutation, embryos fail to form a parapineal organ and develop right-isomerized habenulae. Crucial enzymes in the melatonin biosynthesis pathway are not expressed, suggesting absence of melatonin from the pineal gland of bsx mutants. Several genes involved in rod-like or cone-like phototransduction are also abnormally expressed, indicating that Bsx plays a pivotal role in differentiation of multiple cell types in the zebrafish pineal complex.<\/jats:p>","DOI":"10.1242\/dev.163477","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:45:44Z","timestamp":1529999144000},"source":"Crossref","is-referenced-by-count":18,"title":["Bsx controls pineal complex development"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9965-7712","authenticated-orcid":false,"given":"Theresa","family":"Schredelseker","sequence":"first","affiliation":[{"name":"Developmental Biology, Institute Biology I, Faculty of Biology, Albert-Ludwigs-University Freiburg, Hauptstrasse 1, 79104 Freiburg, Germany"},{"name":"BIOSS - Centre for Biological Signalling Studies, Albertstrasse 19, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9551-9141","authenticated-orcid":false,"given":"Wolfgang","family":"Driever","sequence":"additional","affiliation":[{"name":"Developmental Biology, Institute Biology I, Faculty of Biology, Albert-Ludwigs-University Freiburg, Hauptstrasse 1, 79104 Freiburg, Germany"},{"name":"BIOSS - Centre for Biological Signalling Studies, Albertstrasse 19, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2021042512205680600_DEV163477C1","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s00429-016-1231-z","article-title":"Directional asymmetry in the volume of the human habenula","volume":"222","author":"Ahumada-Galleguillos","year":"2017","journal-title":"Brain Struct. 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