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At the same time, emerging clinical data suggest that the origins of some adult lung diseases are found in embryonic development and childhood. The convergence of these research themes has fuelled a resurgence of interest in human lung developmental biology. In this Review, we discuss our current understanding of human lung development, which has been profoundly influenced by studies in mice and, more recently, by experiments using in vitro human lung developmental models and RNA sequencing of human foetal lung tissue. Together, these approaches are helping to shed light on the mechanisms underlying human lung development and disease, and may help pave the way for new therapies.<\/jats:p>","DOI":"10.1242\/dev.163485","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T03:55:12Z","timestamp":1534305312000},"source":"Crossref","is-referenced-by-count":229,"title":["Human lung development: recent progress and new challenges"],"prefix":"10.1242","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-6848","authenticated-orcid":false,"given":"Marko Z.","family":"Nikoli\u0107","sequence":"first","affiliation":[{"name":"Wellcome Trust\/CRUK Gurdon Institute, Wellcome Trust\/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK"},{"name":"University of Cambridge School of Clinical Medicine, Department of Medicine, Cambridge CB2 0QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-4349","authenticated-orcid":false,"given":"Dawei","family":"Sun","sequence":"additional","affiliation":[{"name":"Wellcome Trust\/CRUK Gurdon Institute, Wellcome Trust\/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7426-3792","authenticated-orcid":false,"given":"Emma L.","family":"Rawlins","sequence":"additional","affiliation":[{"name":"Wellcome Trust\/CRUK Gurdon Institute, Wellcome Trust\/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"2021042512170789600_DEV163485C1","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.1038\/ncomms4923","article-title":"Two nested developmental waves demarcate a compartment boundary in the mouse lung","volume":"5","author":"Alanis","year":"2014","journal-title":"Nat. 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