{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:13:42Z","timestamp":1790626422859,"version":"4.1.0"},"reference-count":43,"publisher":"The Company of Biologists","issue":"15","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 AR067854"],"award-info":[{"award-number":["K08 AR067854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR061376"],"award-info":[{"award-number":["R01 AR061376"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR072650"],"award-info":[{"award-number":["R01 AR072650"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR061313"],"award-info":[{"award-number":["P30 AR061313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The bone tendon attachment site known as the enthesis comprises a transitional zone between bone and tendon, and plays an important role in enabling movement at this site. X-linked hypophosphatemia (XLH) is characterized by impaired activation of vitamin D, elevated serum FGF23 levels and low serum phosphate levels, which impair bone mineralization. Paradoxically, an important complication of XLH is mineralization of the enthesis (enthesopathy). Studies were undertaken to identify the cellular and molecular pathways important for normal post-natal enthesis maturation and to examine their role during the development of enthesopathy in mice with XLH (Hyp). The Achilles tendon entheses of Hyp mice demonstrate an expansion of hypertrophic-appearing chondrogenic cells by P14. Post-natally, cells in wild-type and Hyp entheses similarly descend from scleraxis- and Sox9-expressing progenitors; however, Hyp entheses exhibit an expansion of Sox9-expressing cells, and enhanced BMP and IHH signaling. These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH.<\/jats:p>","DOI":"10.1242\/dev.163519","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T08:55:43Z","timestamp":1531385743000},"source":"Crossref","is-referenced-by-count":25,"title":["Molecular analysis of enthesopathy in a mouse model of hypophosphatemic rickets"],"prefix":"10.1242","volume":"145","author":[{"given":"Eva S.","family":"Liu","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital 1 Division of Endocrinology, Diabetes, and Hypertension , , Boston, MA 02115 , USA"},{"name":"Massachusetts General Hospital 2 Endocrine Unit , , Boston, MA 02114 , USA"},{"name":"Harvard Medical School 3 , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaina S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital 2 Endocrine Unit , , Boston, MA 02114 , USA"},{"name":"Harvard Medical School 3 , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital 2 Endocrine Unit , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-5479","authenticated-orcid":false,"given":"Marie B.","family":"Demay","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital 2 Endocrine Unit , , Boston, MA 02114 , USA"},{"name":"Harvard Medical School 3 , Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"2024061113413116100_DEV163519C1","doi-asserted-by":"publisher","first-page":"14665","DOI":"10.1073\/pnas.0504750102","article-title":"Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors","volume":"102","author":"Akiyama","year":"2005","journal-title":"Proc. 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