{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:12:59Z","timestamp":1792800779090,"version":"4.5.0"},"reference-count":108,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100017023","name":"The Paul G. Allen Frontiers Group","doi-asserted-by":"crossref","award":["12171"],"award-info":[{"award-number":["12171"]}],"id":[{"id":"10.13039\/100017023","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000888","name":"W. M. 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The pattern of depolarization matches that of the amputated limb and is correlated to the position and type of injury, revealing that information about damage is available to remote body tissues and is detectable non-invasively in vivo by monitoring of the bioelectric state. These data extend knowledge about the electrophysiology of regenerative response, identify a novel communication process via long-range spread of injury signaling, a phenomenon which we call bioelectric injury mirroring (BIM), and suggests revisions to regenerative medicine and diagnostic strategies focused entirely on the wound site and to the use of contralateral limbs as controls.<\/jats:p>","DOI":"10.1242\/dev.164210","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T11:39:40Z","timestamp":1534765180000},"source":"Crossref","is-referenced-by-count":25,"title":["Cross-limb communication during <i>Xenopus<\/i> hind-limb regenerative response: non-local bioelectric injury signals"],"prefix":"10.1242","author":[{"given":"Sera M.","family":"Busse","sequence":"first","affiliation":[{"name":"Biology Department and Allen Discovery Center, Tufts University, Medford, MA 02155, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"McMillen","sequence":"additional","affiliation":[{"name":"Biology Department and Allen Discovery Center, Tufts University, Medford, MA 02155, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-8084","authenticated-orcid":false,"given":"Michael","family":"Levin","sequence":"additional","affiliation":[{"name":"Biology Department and Allen Discovery Center, Tufts University, Medford, MA 02155, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2021042609205320700_DEV164210C1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1101\/pdb.top067710","article-title":"General principles for measuring resting membrane potential and ion concentration using fluorescent bioelectricity reporters","volume":"2012","author":"Adams","year":"2012","journal-title":"Cold Spring Harb. 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