{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:51:56Z","timestamp":1787237516501,"version":"build-2736575974"},"reference-count":55,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE018405"],"award-info":[{"award-number":["R01DE018405"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify these cell types remains a mystery. We find that modular expression of Forkhead-domain transcription factors (Fox) in the zebrafish face arises through integration of Hh, Fgf, Bmp, Edn1, and Jagged-Notch pathways. Whereas loss of C-class Fox proteins results in reduced upper facial cartilages, loss of F-class Fox proteins results in distal jaw truncations and absent midline cartilages and teeth. We show that Fox proteins are required for Sox9a to promote chondrogenic gene expression. Fox proteins are sufficient in neural crest-derived cells for cartilage development, and neural crest-specific misexpression of Fox proteins expands the cartilage domain while inhibiting bone. These results support a modular role for Fox proteins in establishing the competency of progenitors to form cartilage and teeth in the face.<\/jats:p>","DOI":"10.1242\/dev.165498","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T04:10:08Z","timestamp":1526616608000},"source":"Crossref","is-referenced-by-count":56,"title":["Fox proteins are modular competency factors for facial cartilage and tooth specification"],"prefix":"10.1242","author":[{"given":"Pengfei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Balczerski","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Ciozda","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Louie","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Oralova","sequence":"additional","affiliation":[{"name":"Evolutionary Developmental Biology, Ghent University, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Huysseune","sequence":"additional","affiliation":[{"name":"Evolutionary Developmental Biology, Ghent University, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-0026","authenticated-orcid":false,"given":"J. 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