{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:18:17Z","timestamp":1774851497655,"version":"3.50.1"},"reference-count":148,"publisher":"The Company of Biologists","issue":"11","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["APP1146800 APP1146352 APP1146706 APP1164000 APP1111169"],"award-info":[{"award-number":["APP1146800 APP1146352 APP1146706 APP1164000 APP1111169"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The lymphatic vasculature is an integral component of the cardiovascular system. It is essential to maintain tissue fluid homeostasis, direct immune cell trafficking and absorb dietary lipids from the digestive tract. Major advances in our understanding of the genetic and cellular events important for constructing the lymphatic vasculature during development have recently been made. These include the identification of novel sources of lymphatic endothelial progenitor cells, the recognition of lymphatic endothelial cell specialisation and heterogeneity, and discovery of novel genes and signalling pathways underpinning developmental lymphangiogenesis. Here, we review these advances and discuss how they inform our understanding of lymphatic network formation, function and dysfunction.<\/jats:p>","DOI":"10.1242\/dev.167098","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T09:06:35Z","timestamp":1622711195000},"source":"Crossref","is-referenced-by-count":20,"title":["When form meets function: the cells and signals that shape the lymphatic vasculature during development"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9846-6882","authenticated-orcid":false,"given":"Mathias","family":"Francois","sequence":"first","affiliation":[{"name":"The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing Program, The Centenary Institute, The University of Sydney, SOLES, 2006 Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-4184","authenticated-orcid":false,"given":"Anna","family":"Oszmiana","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5001, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-8966","authenticated-orcid":false,"given":"Natasha L.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5001, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"2021060309042947000_DEV167098C1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11248-019-00177-8","article-title":"Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines","volume":"29","author":"\u00c1lvarez-Aznar","year":"2020","journal-title":"Transgenic Res."},{"key":"2021060309042947000_DEV167098C2","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1084\/jem.20170391","article-title":"Development and plasticity of meningeal lymphatic vessels","volume":"214","author":"Antila","year":"2017","journal-title":"J. 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