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Therefore, the relevance of SCs during prepubertal growth, a period after weaning but prior to the onset of puberty, has not been examined. Here, we have characterized mouse skeletal muscle growth during prepuberty and found significant increases in myofiber cross-sectional area that correlated with SC-derived myonuclear number. Remarkably, genome-wide RNA-sequencing analysis established that post-weaning juvenile and early adolescent skeletal muscle have markedly different gene expression signatures. These distinctions are consistent with extensive skeletal muscle maturation during this essential, albeit brief, developmental phase. Indelible labeling of SCs with Pax7CreERT2\/+; Rosa26nTnG\/+ mice demonstrated SC-derived myonuclear contribution during prepuberty, with a substantial reduction at puberty onset. Prepubertal depletion of SCs in Pax7CreERT2\/+; Rosa26DTA\/+ mice reduced myofiber size and myonuclear number, and caused force generation deficits to a similar extent in both fast and slow-contracting muscles. Collectively, these data demonstrate SC-derived myonuclear accretion as a cellular mechanism that contributes to prepubertal hypertrophic skeletal muscle growth.<\/jats:p>","DOI":"10.1242\/dev.167197","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T11:58:11Z","timestamp":1539172691000},"source":"Crossref","is-referenced-by-count":134,"title":["Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution"],"prefix":"10.1242","volume":"145","author":[{"given":"John F.","family":"Bachman","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center 1 Department of Pathology and Laboratory Medicine, Cell Biology of Disease Graduate Program , , 601 Elmwood Ave, Rochester, NY 14642 , USA"},{"name":"University of Rochester Medical Center 2 Department of Pharmacology and Physiology , , 601 Elmwood Ave Box 711, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna","family":"Klose","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 2 Department of Pharmacology and Physiology , , 601 Elmwood Ave Box 711, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 2 Department of Pharmacology and Physiology , , 601 Elmwood Ave Box 711, Rochester, NY 14642 , USA"},{"name":"University of Rochester Medical Center 3 Department of Biomedical Genetics, Genetics, Development, and Stem Cells Graduate Program , , 601 Elmwood Ave Box 633, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"Paris","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 2 Department of Pharmacology and Physiology , , 601 Elmwood Ave Box 711, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e9o S.","family":"Blanc","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 2 Department of Pharmacology and Physiology , , 601 Elmwood Ave Box 711, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Schmalz","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 2 Department of Pharmacology and Physiology , , 601 Elmwood Ave Box 711, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Knapp","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 4 Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research , , 601 Elmwood Ave, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-7312","authenticated-orcid":false,"given":"Joe V.","family":"Chakkalakal","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 2 Department of Pharmacology and Physiology , , 601 Elmwood Ave Box 711, Rochester, NY 14642 , USA"},{"name":"University of Rochester Medical Center 5 Wilmot Cancer Institute, Stem Cell and Regenerative Medicine Institute, The Rochester Aging Research Center, and Department of Biomedical Engineering , , 601 Elmwood Ave, Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"2024061300170749600_DEV167197C1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0248-4900(03)00087-X","article-title":"Myosin heavy chain isoforms in postnatal muscle development of mice","volume":"95","author":"Agbulut","year":"2003","journal-title":"Biol. 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