{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:22:03Z","timestamp":1790007723889,"version":"4.0.1"},"reference-count":85,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"crossref","award":["BFU2016-77498-P and BFU2016-81887-REDT"],"award-info":[{"award-number":["BFU2016-77498-P and BFU2016-81887-REDT"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Embryonic development of the central nervous system (CNS) requires the proliferation of neural progenitor cells to be tightly regulated, allowing the formation of an organ with the right size and shape. This includes regulation of both the spatial distribution of mitosis and the mode of cell division. The centrosome, which is the main microtubule-organizing centre of animal cells, contributes to both of these processes. Here, we discuss the impact that centrosome-mediated control of cell division has on the shape of the overall growing CNS. We also review the intrinsic properties of the centrosome, both in terms of its molecular composition and its signalling capabilities, and discuss the fascinating notion that intrinsic centrosomal asymmetries in dividing neural progenitor cells are instructive for neurogenesis. Finally, we discuss the genetic links between centrosome dysfunction during development and the aetiology of microcephaly.<\/jats:p>","DOI":"10.1242\/dev.170613","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T13:19:23Z","timestamp":1541510363000},"source":"Crossref","is-referenced-by-count":41,"title":["A centrosomal view of CNS growth"],"prefix":"10.1242","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-4291","authenticated-orcid":false,"given":"Murielle","family":"Saade","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, Parc Cient\u00ed\ufb01c de Barcelona, Baldiri i Reixac 20, Barcelona 08028, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Blanco-Ameijeiras","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, Parc Cient\u00ed\ufb01c de Barcelona, Baldiri i Reixac 20, Barcelona 08028, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gonzalez-Gobartt","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, Parc Cient\u00ed\ufb01c de Barcelona, Baldiri i Reixac 20, Barcelona 08028, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-0069","authenticated-orcid":false,"given":"Elisa","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, Parc Cient\u00ed\ufb01c de Barcelona, Baldiri i Reixac 20, Barcelona 08028, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"2021042609163431800_DEV170613C1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/bs.ctdb.2015.10.019","article-title":"Segment identity and cell segregation in the vertebrate hindbrain","volume":"117","author":"Addison","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"key":"2021042609163431800_DEV170613C2","doi-asserted-by":"publisher","first-page":"14894","DOI":"10.1038\/s41598-017-14241-y","article-title":"Akap350 recruits Eb1 to the spindle poles, ensuring proper spindle orientation and lumen formation in 3D epithelial cell cultures","volume":"7","author":"Almada","year":"2017","journal-title":"Sci. Rep."},{"key":"2021042609163431800_DEV170613C3","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1242\/dev.041772","article-title":"Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation","volume":"136","author":"Alvarez-Medina","year":"2009","journal-title":"Development"},{"key":"2021042609163431800_DEV170613C4","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.cub.2009.07.034","article-title":"Centriole age underlies asynchronous primary cilium growth in mammalian cells","volume":"19","author":"Anderson","year":"2009","journal-title":"Curr. Biol."},{"key":"2021042609163431800_DEV170613C5","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.neuron.2010.03.036","article-title":"Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex","volume":"66","author":"Buchman","year":"2010","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.neuron.2009.07.004","article-title":"Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex","volume":"63","author":"Bultje","year":"2009","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C7","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1242\/dev.02228","article-title":"The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity","volume":"133","author":"Cayuso","year":"2006","journal-title":"Development"},{"key":"2021042609163431800_DEV170613C8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ydbio.2011.06.029","article-title":"Phosphorylated beta-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain","volume":"357","author":"Chilov","year":"2011","journal-title":"Dev. Biol."},{"key":"2021042609163431800_DEV170613C9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.gde.2013.04.003","article-title":"Morphogen interpretation: the transcriptional logic of neural tube patterning","volume":"23","author":"Cohen","year":"2013","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2021042609163431800_DEV170613C10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1083\/jcb.200204023","article-title":"Assembly of centrosomal proteins and microtubule organization depends on PCM-1","volume":"159","author":"Dammermann","year":"2002","journal-title":"J. Cell Biol."},{"key":"2021042609163431800_DEV170613C11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1126\/science.1247521","article-title":"Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis","volume":"343","author":"Das","year":"2014","journal-title":"Science"},{"key":"2021042609163431800_DEV170613C12","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cell.2008.07.017","article-title":"Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient","volume":"134","author":"Del Bene","year":"2008","journal-title":"Cell"},{"key":"2021042609163431800_DEV170613C13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1083\/jcb.200608137","article-title":"Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1","volume":"176","author":"Dubreuil","year":"2007","journal-title":"J. Cell Biol."},{"key":"2021042609163431800_DEV170613C14","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0896-6273(00)00145-8","article-title":"LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C15","doi-asserted-by":"publisher","first-page":"10438","DOI":"10.1073\/pnas.0604066103","article-title":"Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells","volume":"103","author":"Fish","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042609163431800_DEV170613C16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.conb.2016.11.004","article-title":"Human-specific genomic signatures of neocortical expansion","volume":"42","author":"Florio","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"2021042609163431800_DEV170613C17","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.cell.2007.09.027","article-title":"Integrating patterning signals: Wnt\/GSK3 regulates the duration of the BMP\/Smad1 signal","volume":"131","author":"Fuentealba","year":"2007","journal-title":"Cell"},{"key":"2021042609163431800_DEV170613C18","doi-asserted-by":"publisher","first-page":"7732","DOI":"10.1073\/pnas.0803027105","article-title":"Asymmetric mitosis: unequal segregation of proteins destined for degradation","volume":"105","author":"Fuentealba","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042609163431800_DEV170613C19","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.15252\/embr.201541823","article-title":"ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules","volume":"17","author":"Gai","year":"2016","journal-title":"EMBO Rep."},{"key":"2021042609163431800_DEV170613C20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuron.2010.01.011","article-title":"Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis","volume":"65","author":"Ge","year":"2010","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C21","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/embo-reports\/kvd105","article-title":"The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin","volume":"1","author":"Gillingham","year":"2000","journal-title":"EMBO Rep."},{"key":"2021042609163431800_DEV170613C22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/wdev.89","article-title":"Genetic causes of microcephaly and lessons for neuronal development","volume":"2","author":"Gilmore","year":"2013","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"2021042609163431800_DEV170613C23","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nrg2774","article-title":"The primary cilium: a signalling centre during vertebrate development","volume":"11","author":"Goetz","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"2021042609163431800_DEV170613C24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1083\/jcb.200707181","article-title":"Cep164, a novel centriole appendage protein required for primary cilium formation","volume":"179","author":"Graser","year":"2007","journal-title":"J. Cell Biol."},{"key":"2021042609163431800_DEV170613C25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-neuro-062012-170354","article-title":"Neural tube defects","volume":"37","author":"Greene","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"2021042609163431800_DEV170613C26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ydbio.2016.03.019","article-title":"Roof plate mediated morphogenesis of the forebrain: new players join the game","volume":"413","author":"Gupta","year":"2016","journal-title":"Dev. Biol."},{"key":"2021042609163431800_DEV170613C27","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1126\/science.1231077","article-title":"A localized Wnt signal orients asymmetric stem cell division in vitro","volume":"339","author":"Habib","year":"2013","journal-title":"Science"},{"key":"2021042609163431800_DEV170613C28","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1242\/dev.102988","article-title":"Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates","volume":"141","author":"Hatakeyama","year":"2014","journal-title":"Development"},{"key":"2021042609163431800_DEV170613C29","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ceb.2017.11.008","article-title":"Novel gene function and regulation in neocortex expansion","volume":"49","author":"Heide","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"2021042609163431800_DEV170613C30","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0092-8674(03)00642-1","article-title":"Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells","volume":"114","author":"Hirota","year":"2003","journal-title":"Cell"},{"key":"2021042609163431800_DEV170613C31","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.semcdb.2009.07.002","article-title":"Centriole maturation and transformation to basal body","volume":"21","author":"Hoyer-Fender","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"2021042609163431800_DEV170613C32","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/nn.3831","article-title":"Cortical neurogenesis in the absence of centrioles","volume":"17","author":"Insolera","year":"2014","journal-title":"Nat. Neurosci."},{"key":"2021042609163431800_DEV170613C33","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/ncb1251","article-title":"Odf2-deficient mother centrioles lack distal\/subdistal appendages and the ability to generate primary cilia","volume":"7","author":"Ishikawa","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"2021042609163431800_DEV170613C34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/ncb918","article-title":"Active cyclin B1-Cdk1 first appears on centrosomes in prophase","volume":"5","author":"Jackman","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"2021042609163431800_DEV170613C35","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.neuron.2016.09.056","article-title":"Microcephaly proteins Wdr62 and Aspm define a mother centriole complex regulating centriole biogenesis, apical complex, and cell fate","volume":"92","author":"Jayaraman","year":"2016","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-genom-083117-021441","article-title":"The genetics of primary microcephaly","volume":"19","author":"Jayaraman","year":"2018","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"2021042609163431800_DEV170613C37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.conb.2016.11.001","article-title":"Cerebral cortical neuron diversity and development at single-cell resolution","volume":"42","author":"Johnson","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"2021042609163431800_DEV170613C38","doi-asserted-by":"publisher","first-page":"e26215","DOI":"10.7554\/eLife.26215","article-title":"Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination","volume":"6","author":"Kasioulis","year":"2017","journal-title":"eLife"},{"key":"2021042609163431800_DEV170613C39","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07519","article-title":"Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication","volume":"4","author":"Kodani","year":"2015","journal-title":"eLife"},{"key":"2021042609163431800_DEV170613C40","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/ncb1673","article-title":"Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis","volume":"10","author":"Konno","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2021042609163431800_DEV170613C41","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1242\/dev.01922","article-title":"Mind bomb 1 is essential for generating functional Notch ligands to activate Notch","volume":"132","author":"Koo","year":"2005","journal-title":"Development"},{"key":"2021042609163431800_DEV170613C42","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1038\/sj.emboj.7600223","article-title":"Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells","volume":"23","author":"Kosodo","year":"2004","journal-title":"EMBO J."},{"key":"2021042609163431800_DEV170613C43","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1038\/emboj.2011.81","article-title":"Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain","volume":"30","author":"Kosodo","year":"2011","journal-title":"EMBO J."},{"key":"2021042609163431800_DEV170613C44","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.conb.2012.04.003","article-title":"Spindle orientation in mammalian cerebral cortical development","volume":"22","author":"Lancaster","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"2021042609163431800_DEV170613C45","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/cne.901270308","article-title":"Behavior of neuro-epithelial cells during closure of the neural tube","volume":"127","author":"Langman","year":"1966","journal-title":"J. Comp. Neurol."},{"key":"2021042609163431800_DEV170613C46","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1002\/dneu.22015","article-title":"Dorsal-ventral patterning of the neural tube: a tale of three signals","volume":"72","author":"Le Dr\u00e9au","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"2021042609163431800_DEV170613C47","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1083\/jcb.201307031","article-title":"The strength of SMAD1\/5 activity determines the mode of stem cell division in the developing spinal cord","volume":"204","author":"Le Dr\u00e9au","year":"2014","journal-title":"J. Cell Biol."},{"key":"2021042609163431800_DEV170613C48","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tcb.2012.11.001","article-title":"Mechanisms controlling arrangements and movements of nuclei in pseudostratified epithelia","volume":"23","author":"Lee","year":"2013","journal-title":"Trends Cell Biol."},{"key":"2021042609163431800_DEV170613C49","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.gde.2010.04.013","article-title":"Neural stem cells: the need for a proper orientation","volume":"20","author":"Lesage","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2021042609163431800_DEV170613C50","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ceb.2011.12.012","article-title":"Pattern formation in centrosome assembly","volume":"24","author":"Mahen","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"2021042609163431800_DEV170613C51","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/embor.2009.36","article-title":"Adherens junction domains are split by asymmetric division of embryonic neural stem cells","volume":"10","author":"Marthiens","year":"2009","journal-title":"EMBO Rep."},{"key":"2021042609163431800_DEV170613C52","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0166-2236(02)02062-3","article-title":"Sonic hedgehog in CNS development: one signal, multiple outputs","volume":"25","author":"Mart\u00ed","year":"2002","journal-title":"Trends Neurosci."},{"key":"2021042609163431800_DEV170613C53","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ydbio.2016.12.022","article-title":"Playing with the cell cycle to build the spinal cord","volume":"432","author":"Molina","year":"2017","journal-title":"Dev. Biol."},{"key":"2021042609163431800_DEV170613C54","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1038\/nn1984","article-title":"Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium","volume":"10","author":"Morin","year":"2007","journal-title":"Nat. Neurosci."},{"key":"2021042609163431800_DEV170613C55","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-3-319-57127-0_2","article-title":"Consequences of centrosome dysfunction during brain development","volume":"1002","author":"Nano","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"2021042609163431800_DEV170613C56","doi-asserted-by":"publisher","first-page":"e16550","DOI":"10.7554\/eLife.16550","article-title":"Physical association between a novel plasma-membrane structure and centrosome orients cell division","volume":"5","author":"Negishi","year":"2016","journal-title":"eLife"},{"key":"2021042609163431800_DEV170613C57","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.neuron.2010.12.026","article-title":"Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells","volume":"69","author":"Ohata","year":"2011","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C58","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1242\/jcs.115.9.1825","article-title":"CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation","volume":"115","author":"Ou","year":"2002","journal-title":"J. Cell Sci."},{"key":"2021042609163431800_DEV170613C59","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.cell.2013.08.060","article-title":"Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division","volume":"155","author":"Paridaen","year":"2013","journal-title":"Cell"},{"key":"2021042609163431800_DEV170613C61","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.devcel.2007.01.021","article-title":"Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells","volume":"12","author":"Rebollo","year":"2007","journal-title":"Dev. Cell"},{"key":"2021042609163431800_DEV170613C62","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1242\/jcs.111.16.2283","article-title":"Mechanisms of nuclear positioning","volume":"111","author":"Reinsch","year":"1998","journal-title":"J. Cell Sci."},{"key":"2021042609163431800_DEV170613C63","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.15252\/embr.201643048","article-title":"Loss of the canonical spindle orientation function in the Pins\/LGN homolog AGS3","volume":"18","author":"Saadaoui","year":"2017","journal-title":"EMBO Rep."},{"key":"2021042609163431800_DEV170613C64","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.celrep.2013.06.038","article-title":"Sonic hedgehog signaling switches the mode of division in the developing nervous system","volume":"4","author":"Saade","year":"2013","journal-title":"Cell Rep."},{"key":"2021042609163431800_DEV170613C65","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/ncb3512","article-title":"Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division","volume":"19","author":"Saade","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2021042609163431800_DEV170613C66","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/cne.900620207","article-title":"Mitosis in the neural tube","volume":"62","author":"Sauer","year":"1935","journal-title":"J. Comp. Neurol."},{"key":"2021042609163431800_DEV170613C67","doi-asserted-by":"publisher","first-page":"16487","DOI":"10.1073\/pnas.0908928106","article-title":"Myosin II is required for interkinetic nuclear migration of neural progenitors","volume":"106","author":"Schenk","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042609163431800_DEV170613C68","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1083\/jcb.201202126","article-title":"Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis","volume":"199","author":"Schmidt","year":"2012","journal-title":"J. Cell Biol."},{"key":"2021042609163431800_DEV170613C69","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1440-169X.2012.01345.x","article-title":"Control of asymmetric cell division of mammalian neural progenitors","volume":"54","author":"Shitamukai","year":"2012","journal-title":"Dev. Growth Differ."},{"key":"2021042609163431800_DEV170613C70","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1523\/JNEUROSCI.4773-10.2011","article-title":"Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer subventricular zone progenitors","volume":"31","author":"Shitamukai","year":"2011","journal-title":"J. Neurosci."},{"key":"2021042609163431800_DEV170613C71","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.gde.2010.04.008","article-title":"Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain","volume":"20","author":"Sousa","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2021042609163431800_DEV170613C72","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.devcel.2014.12.001","article-title":"Interkinetic nuclear migration is centrosome independent and ensures apical cell division to maintain tissue integrity","volume":"32","author":"Strzyz","year":"2015","journal-title":"Dev. Cell"},{"key":"2021042609163431800_DEV170613C73","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1083\/jcb.200309025","article-title":"Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration","volume":"165","author":"Tanaka","year":"2004","journal-title":"J. Cell Biol."},{"key":"2021042609163431800_DEV170613C74","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.neuron.2016.12.042","article-title":"Differential routing of mindbomb1 via centriolar satellites regulates asymmetric divisions of neural progenitors","volume":"93","author":"Tozer","year":"2017","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C75","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/nn.2665","article-title":"Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells","volume":"13","author":"Tsai","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2021042609163431800_DEV170613C76","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1242\/jcs.057851","article-title":"FAK-mediated extracellular signals are essential for interkinetic nuclear migration and planar divisions in the neuroepithelium","volume":"123","author":"Tsuda","year":"2010","journal-title":"J. Cell Sci."},{"key":"2021042609163431800_DEV170613C77","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.4161\/cc.6.21.4822","article-title":"Morphogens and the control of cell proliferation and patterning in the spinal cord","volume":"6","author":"Ulloa","year":"2007","journal-title":"Cell Cycle"},{"key":"2021042609163431800_DEV170613C78","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/dvdy.22058","article-title":"Wnt won the war: antagonistic role of Wnt over Shh controls dorso-ventral patterning of the vertebrate neural tube","volume":"239","author":"Ulloa","year":"2010","journal-title":"Dev. Dyn."},{"key":"2021042609163431800_DEV170613C79","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.cub.2015.02.020","article-title":"Centrosome-associated degradation limits beta-catenin inheritance by daughter cells after asymmetric division","volume":"25","author":"Vora","year":"2015","journal-title":"Curr. Biol."},{"key":"2021042609163431800_DEV170613C80","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/nature08435","article-title":"Asymmetric centrosome inheritance maintains neural progenitors in the neocortex","volume":"461","author":"Wang","year":"2009","journal-title":"Nature"},{"key":"2021042609163431800_DEV170613C81","doi-asserted-by":"publisher","first-page":"4786","DOI":"10.1091\/mbc.e12-03-0214","article-title":"The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle","volume":"23","author":"Welburn","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"2021042609163431800_DEV170613C82","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1242\/dev.002519","article-title":"Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cord","volume":"134","author":"Wilcock","year":"2007","journal-title":"Development"},{"key":"2021042609163431800_DEV170613C83","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.conb.2016.05.004","article-title":"Neocortex expansion in development and evolution - from cell biology to single genes","volume":"39","author":"Wilsch-Br\u00e4uninger","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"2021042609163431800_DEV170613C84","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuron.2007.08.026","article-title":"Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool","volume":"56","author":"Xie","year":"2007","journal-title":"Neuron"},{"key":"2021042609163431800_DEV170613C85","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1126\/science.1134910","article-title":"Asymmetric inheritance of mother versus daughter centrosome in stem cell division","volume":"315","author":"Yamashita","year":"2007","journal-title":"Science"},{"key":"2021042609163431800_DEV170613C86","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neuron.2009.08.018","article-title":"SUN1\/2 and Syne\/Nesprin-1\/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice","volume":"64","author":"Zhang","year":"2009","journal-title":"Neuron"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.170613","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.170613\/1854172\/dev170613.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.170613\/1854172\/dev170613.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:42:41Z","timestamp":1619444561000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/145\/21\/dev170613\/48516\/A-centrosomal-view-of-CNS-growth"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":85,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.170613","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,1]]},"article-number":"dev170613"}}