{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:36:42Z","timestamp":1784079402013,"version":"3.55.0"},"reference-count":68,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP: 111013"],"award-info":[{"award-number":["MOP: 111013"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Amputation of a salamander limb triggers a regeneration process that is perfect. A limited number of genes have been studied in this context and even fewer have been analyzed functionally. In this work, we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore the role of BMPs in regeneration. We find that BMP signaling is required for proper expression of various patterning genes and that its inhibition causes major defects in the regenerated limbs. Fgf8 is downregulated when BMP signaling is blocked, but ectopic injection of either human or axolotl protein did not rescue the defects. By administering LDN193189 treatments at different time points during regeneration, we show clearly that limb regeneration progresses in a proximal to distal fashion. This demonstrates that BMPs play a major role in patterning of regenerated limbs and that regeneration is a progressive process like development.<\/jats:p>","DOI":"10.1242\/dev.170829","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T19:27:44Z","timestamp":1594754864000},"source":"Crossref","is-referenced-by-count":40,"title":["BMP signaling is essential for sustaining proximo-distal progression in regenerating axolotl limbs"],"prefix":"10.1242","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-9603","authenticated-orcid":false,"given":"Etienne","family":"Vincent","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al 1 Department of Biochemistry and Molecular Medicine, Faculty of Medicine , , Montr\u00e9al, Qu\u00e9bec , H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Villiard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al 3 Department of Stomatology, Faculty of Dentistry , , Montr\u00e9al, Qu\u00e9bec , H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Sader","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al 1 Department of Biochemistry and Molecular Medicine, Faculty of Medicine , , Montr\u00e9al, Qu\u00e9bec , H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabin","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Institute for Research in Immunology and Cancer (IRIC) 2 , D\u00e9partement de m\u00e9decine , , Montr\u00e9al , H3T 1J4, Canada"},{"name":"Universit\u00e9 de Montr\u00e9al 2 , D\u00e9partement de m\u00e9decine , , Montr\u00e9al , H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.","family":"Kwok","sequence":"additional","affiliation":[{"name":"Institute for Research in Immunology and Cancer (IRIC) 2 , D\u00e9partement de m\u00e9decine , , Montr\u00e9al , H3T 1J4, Canada"},{"name":"Universit\u00e9 de Montr\u00e9al 2 , D\u00e9partement de m\u00e9decine , , Montr\u00e9al , H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4504-0968","authenticated-orcid":false,"given":"St\u00e9phane","family":"Roy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al 1 Department of Biochemistry and Molecular Medicine, Faculty of Medicine , , Montr\u00e9al, Qu\u00e9bec , H3T 1J4, Canada"},{"name":"Universit\u00e9 de Montr\u00e9al 3 Department of Stomatology, Faculty of Dentistry , , Montr\u00e9al, Qu\u00e9bec , H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"2024061301361520500_DEV170829C1","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1002\/dvdy.10249","article-title":"Intercalary regeneration in planarians","volume":"226","author":"Agata","year":"2003","journal-title":"Dev. 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