{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:11:36Z","timestamp":1790161896578,"version":"4.1.0"},"reference-count":69,"publisher":"The Company of Biologists","issue":"23","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":187,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The organized array of smooth muscle cells (SMCs) and fibroblasts in the walls of visceral tubular organs arises by patterning and differentiation of mesenchymal progenitors surrounding the epithelial lumen. Here, we show that the TBX2 and TBX3 transcription factors have novel and required roles in regulating these processes in the murine ureter. Co-expression of TBX2 and TBX3 in the inner mesenchymal region of the developing ureter requires canonical WNT signaling. Loss of TBX2\/TBX3 in this region disrupts activity of two crucial drivers of the SMC program, Foxf1 and BMP4 signaling, resulting in decreased SMC differentiation and increased extracellular matrix. Transcriptional profiling and chromatin immunoprecipitation experiments revealed that TBX2\/TBX3 directly repress expression of the WNT antagonists Dkk2 and Shisa2, the BMP antagonist Bmper and the chemokine Cxcl12. These findings suggest that TBX2\/TBX3 are effectors of canonical WNT signaling in the ureteric mesenchyme that promote SMC differentiation by maintaining BMP4 and WNT signaling in the inner region, while restricting CXCL12 signaling to the outer layer of fibroblast-fated mesenchyme.<\/jats:p>","DOI":"10.1242\/dev.171827","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T14:45:16Z","timestamp":1543243516000},"source":"Crossref","is-referenced-by-count":42,"title":["TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme"],"prefix":"10.1242","volume":"145","author":[{"given":"Nurullah","family":"Aydo\u011fdu","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , 30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Rudat","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , 30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark-Oliver","family":"Trowe","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , 30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , 30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo H.","family":"L\u00fcdtke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , 30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto Mark","family":"Taketo","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Kyoto University 2 Division of Experimental Therapeutics , , Kyoto 606-8501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent M.","family":"Christoffels","sequence":"additional","affiliation":[{"name":"Academic Medical Center, University of Amsterdam 3 Department of Anatomy, Embryology and Physiology , , 1105 AZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moon","sequence":"additional","affiliation":[{"name":"Weis Center for Research, Geisinger Clinic 4 Department of Molecular and Functional Genomics , , Danville PA 17822 , USA"},{"name":"University of Utah School of Medicine 5 Departments of Pediatrics and Human Genetics , , Salt Lake City, UT 84112 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-0257","authenticated-orcid":false,"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , 30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"2024061300204564700_DEV171827C1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1172\/JCI26027","article-title":"Tbx18 regulates the development of the ureteral mesenchyme","volume":"116","author":"Airik","year":"2006","journal-title":"J. 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