{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T19:59:16Z","timestamp":1784145556281,"version":"3.55.0"},"reference-count":60,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"crossref","award":["81525011"],"award-info":[{"award-number":["81525011"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB19000000"],"award-info":[{"award-number":["XDB19000000"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31601193"],"award-info":[{"award-number":["31601193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>WDR62 is the second most common genetic alteration associated with microcephaly. Our previous study demonstrates that Wdr62 is required for germ cell meiosis initiation and the majority of male germ cells are lost as the meiotic defect of first wave spermatogenesis. Strikingly, in this study, we found that the initiation of meiosis of following spermatogenesis was not affected and the germ cells were gradually repopulated at later developmental stages. However, most germ cells were arrested at metaphase of meiosis I and no mature sperm were detected in epididymides. Further studies demonstrated that metaphase I arrest of Wdr62-deficient spermatocytes was caused by asymmetrical distribution of the centrosome and aberrant spindle assembly. Mechanistic studies demonstrated that WDR62 interacted with centriole-associated protein CEP170, and deletion of Wdr62 caused downregulation of the CEP170 protein which in turn led to the aberrant spindle assembly. In summary, this study indicates that the meiosis of first wave spermatogenesis and the following spermatogenesis started from spermatogonium is probably regulated by different mechanisms. We also demonstrated a new function of WDR62 in germ cell meiosis by interacting with CEP170.<\/jats:p>","DOI":"10.1242\/dev.174128","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T13:25:13Z","timestamp":1568813113000},"source":"Crossref","is-referenced-by-count":22,"title":["WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis"],"prefix":"10.1242","author":[{"given":"Yan","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock School of Life Sciences, Inner Mongolia University, Hohhot, P.R.China 010070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyang","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Behrens","sequence":"additional","affiliation":[{"name":"CR-UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[{"name":"The department chemistry, Beijing capital normal university, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, 100101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, 100101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-6411","authenticated-orcid":false,"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"2021042623480902700_DEV174128C1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/ncb1826","article-title":"Mouse differentiating spermatogonia can generate germinal stem cells in vivo","volume":"11","author":"Barroca","year":"2009","journal-title":"Nat. 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