{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:30:26Z","timestamp":1788262226295,"version":"build-2803163510"},"reference-count":85,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1010851"],"award-info":[{"award-number":["1010851"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1008699"],"award-info":[{"award-number":["1008699"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1051078"],"award-info":[{"award-number":["1051078"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1003435"],"award-info":[{"award-number":["1003435"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["575512"],"award-info":[{"award-number":["575512"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1081421"],"award-info":[{"award-number":["1081421"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1058892"],"award-info":[{"award-number":["1058892"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001047","name":"Ian Potter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Oral clefts are common birth defects. Individuals with oral clefts who have identical genetic mutations regularly present with variable penetrance and severity. Epigenetic or chromatin-mediated mechanisms are commonly invoked to explain variable penetrance. However, specific examples of these are rare. Two functional copies of the MOZ (KAT6A, MYST3) gene, encoding a MYST family lysine acetyltransferase chromatin regulator, are essential for human craniofacial development, but the molecular role of MOZ in this context is unclear. Using genetic interaction and genomic studies, we have investigated the effects of loss of MOZ on the gene expression program during mouse development. Among the more than 500 genes differentially expressed after loss of MOZ, 19 genes had previously been associated with cleft palates. These included four distal-less homeobox (DLX) transcription factor-encoding genes, Dlx1, Dlx2, Dlx3 and Dlx5 and DLX target genes (including Barx1, Gbx2, Osr2 and Sim2). MOZ occupied the Dlx5 locus and was required for normal levels of histone H3 lysine 9 acetylation. MOZ affected Dlx gene expression cell-autonomously within neural crest cells. Our study identifies a specific program by which the chromatin modifier MOZ regulates craniofacial development.<\/jats:p>","DOI":"10.1242\/dev.175042","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T19:55:15Z","timestamp":1563998115000},"source":"Crossref","is-referenced-by-count":31,"title":["MOZ directs the distal-less homeobox gene expression program during craniofacial development"],"prefix":"10.1242","volume":"146","author":[{"given":"Hannah K.","family":"Vanyai","sequence":"first","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"},{"name":"University of Melbourne 2 Department of Medical Biology , , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Garnham","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose E.","family":"May","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"McRae","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"},{"name":"University of Melbourne 2 Department of Medical Biology , , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Collin","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-2892","authenticated-orcid":false,"given":"Gordon K.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"},{"name":"University of Melbourne 3 Department School of Mathematics and Statistics , , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Thomas","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"},{"name":"University of Melbourne 2 Department of Medical Biology , , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3853-9381","authenticated-orcid":false,"given":"Anne K.","family":"Voss","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research, Melbourne 1 , Parkville, VIC 3052 , Australia"},{"name":"University of Melbourne 2 Department of Medical Biology , , Parkville, VIC 3052 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"2024061301021181200_DEV175042C1","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1242\/dev.126.17.3795","article-title":"Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5","volume":"126","author":"Acampora","year":"1999","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.ajhg.2015.01.017","article-title":"De novo nonsense mutations in KAT6A, a lysine acetyl-transferase gene, cause a syndrome including microcephaly and global developmental delay","volume":"96","author":"Arboleda","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"2024061301021181200_DEV175042C3","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1242\/dev.056929","article-title":"Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis","volume":"138","author":"Barron","year":"2011","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C4","doi-asserted-by":"publisher","first-page":"a008326","DOI":"10.1101\/cshperspect.a008326","article-title":"Signals and switches in Mammalian neural crest cell differentiation","volume":"5","author":"Bhatt","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2024061301021181200_DEV175042C5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/ng0996-33","article-title":"The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein","volume":"14","author":"Borrow","year":"1996","journal-title":"Nat. Genet."},{"key":"2024061301021181200_DEV175042C6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1242\/dev.067082","article-title":"Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development","volume":"139","author":"Bush","year":"2012","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C7","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.ajhg.2011.11.023","article-title":"Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome","volume":"90","author":"Campeau","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"2024061301021181200_DEV175042C8","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1101\/gad.931701","article-title":"Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer","volume":"15","author":"Charite","year":"2001","journal-title":"Genes Dev."},{"key":"2024061301021181200_DEV175042C9","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.ajhg.2011.10.008","article-title":"Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome","volume":"89","author":"Clayton-Smith","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"2024061301021181200_DEV175042C10","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1242\/dev.02435","article-title":"Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face","volume":"133","author":"Crump","year":"2006","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C11","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr. Biol."},{"key":"2024061301021181200_DEV175042C12","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1242\/dev.126.17.3831","article-title":"Dlx5 regulates regional development of the branchial arches and sensory capsules","volume":"126","author":"Depew","year":"1999","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C13","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1126\/science.1075703","article-title":"Specification of jaw subdivisions by Dlx genes","volume":"298","author":"Depew","year":"2002","journal-title":"Science"},{"key":"2024061301021181200_DEV175042C14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1469-7580.2005.00487.x","article-title":"Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development","volume":"207","author":"Depew","year":"2005","journal-title":"J. Anat."},{"key":"2024061301021181200_DEV175042C15","doi-asserted-by":"publisher","first-page":"e1000582","DOI":"10.1371\/journal.pbio.1000582","article-title":"A high-resolution anatomical atlas of the transcriptome in the mouse embryo","volume":"9","author":"Diez-Roux","year":"2011","journal-title":"PLoS Biol."},{"key":"2024061301021181200_DEV175042C16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"2024061301021181200_DEV175042C17","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation","volume":"89","author":"Ducy","year":"1997","journal-title":"Cell"},{"key":"2024061301021181200_DEV175042C18","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/ajmg.a.31244","article-title":"Genotype-phenotype correlations in mapped split hand foot malformation (SHFM) patients","volume":"140A","author":"Elliott","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"2024061301021181200_DEV175042C19","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.ydbio.2007.08.057","article-title":"Menin is required in cranial neural crest for palatogenesis and perinatal viability","volume":"311","author":"Engleka","year":"2007","journal-title":"Dev. Biol."},{"key":"2024061301021181200_DEV175042C20","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1128\/MCB.01520-09","article-title":"PHF8 targets histone methylation and RNA polymerase II to activate transcription","volume":"30","author":"Fortschegger","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"2024061301021181200_DEV175042C21","doi-asserted-by":"publisher","first-page":"9648","DOI":"10.1073\/pnas.88.21.9648","article-title":"Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene","volume":"88","author":"Garofalo","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061301021181200_DEV175042C22","doi-asserted-by":"publisher","first-page":"9585","DOI":"10.1073\/pnas.1402485111","article-title":"Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ","volume":"111","author":"Good-Jacobson","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061301021181200_DEV175042C23","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.1016\/j.celrep.2018.08.048","article-title":"Subtle changes in the levels of BCL-2 proteins cause severe craniofacial abnormalities","volume":"24","author":"Grabow","year":"2018","journal-title":"Cell Rep."},{"key":"2024061301021181200_DEV175042C24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3727\/000000001783992515","article-title":"Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development","volume":"9","author":"Green","year":"2001","journal-title":"Gene Expr."},{"key":"2024061301021181200_DEV175042C25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ydbio.2006.07.042","article-title":"Molecular control of secondary palate development","volume":"301","author":"Gritli-Linde","year":"2007","journal-title":"Dev. Biol."},{"key":"2024061301021181200_DEV175042C26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0070-2153(08)00602-9","article-title":"The etiopathogenesis of cleft lip and cleft palate: usefulness and caveats of mouse models","volume":"84","author":"Gritli-Linde","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"2024061301021181200_DEV175042C27","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/EDE.0b013e3182125f9c","article-title":"Risk of oral clefts in twins","volume":"22","author":"Grosen","year":"2011","journal-title":"Epidemiology"},{"key":"2024061301021181200_DEV175042C28","doi-asserted-by":"publisher","first-page":"4225","DOI":"10.1242\/dev.036723","article-title":"Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice","volume":"136","author":"Han","year":"2009","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C29","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.gde.2009.09.001","article-title":"Transcriptional networks controlling skeletal development","volume":"19","author":"Hartmann","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2024061301021181200_DEV175042C30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0925-4773(02)00207-1","article-title":"Transcription factors Nkx3.1 and Nkx3.2 (Bapx1) play an overlapping role in sclerotomal development of the mouse","volume":"117","author":"Herbrand","year":"2002","journal-title":"Mech. Dev."},{"key":"2024061301021181200_DEV175042C31","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.devcel.2016.04.002","article-title":"Sp7\/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification","volume":"37","author":"Hojo","year":"2016","journal-title":"Dev. Cell"},{"key":"2024061301021181200_DEV175042C32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"2024061301021181200_DEV175042C33","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1242\/dev.019778","article-title":"Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs","volume":"135","author":"Jeong","year":"2008","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C34","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1002\/dvdy.23867","article-title":"Cleft palate defect of Dlx1\/2\u2212\/\u2212 mutant mice is caused by lack of vertical outgrowth in the posterior palate","volume":"241","author":"Jeong","year":"2012","journal-title":"Dev. Dyn."},{"key":"2024061301021181200_DEV175042C35","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.3892\/etm.2017.5240","article-title":"Wnt6 influences the viability of mouse embryonic palatal mesenchymal cells via the beta-catenin pathway","volume":"14","author":"Jiang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"2024061301021181200_DEV175042C36","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1101\/gad.1393106","article-title":"MOZ is essential for maintenance of hematopoietic stem cells","volume":"20","author":"Katsumoto","year":"2006","journal-title":"Genes Dev."},{"key":"2024061301021181200_DEV175042C37","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.cell.2018.04.036","article-title":"Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK","volume":"173","author":"Ke","year":"2018","journal-title":"Cell"},{"key":"2024061301021181200_DEV175042C38","doi-asserted-by":"publisher","first-page":"7101","DOI":"10.1074\/jbc.M006215200","article-title":"Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes","volume":"276","author":"Kern","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2024061301021181200_DEV175042C39","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"2024061301021181200_DEV175042C40","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/bs.ctdb.2015.07.002","article-title":"Cellular and molecular mechanisms of palatogenesis","volume":"115","author":"Lan","year":"2015","journal-title":"Curr. Top. Dev. Biol."},{"key":"2024061301021181200_DEV175042C41","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1136\/jmg.2004.029439","article-title":"Mutations in PHF8 are associated with X linked mental retardation and cleft lip\/cleft palate","volume":"42","author":"Laumonnier","year":"2005","journal-title":"J. Med. Genet."},{"key":"2024061301021181200_DEV175042C42","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"2024061301021181200_DEV175042C43","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0070-2153(10)90008-2","article-title":"Vertebrate skeletogenesis","volume":"90","author":"Lefebvre","year":"2010","journal-title":"Curr. Top. Dev. Biol."},{"key":"2024061301021181200_DEV175042C44","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1128\/MCB.17.4.2336","article-title":"SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene","volume":"17","author":"Lefebvre","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"2024061301021181200_DEV175042C45","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1093\/nar\/gkt214","article-title":"The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote","volume":"41","author":"Liao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2024061301021181200_DEV175042C46","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2024061301021181200_DEV175042C47","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00439-013-1263-x","article-title":"Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate","volume":"132","author":"Lindgren","year":"2013","journal-title":"Hum. Genet."},{"key":"2024061301021181200_DEV175042C48","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/hmg\/ddp480","article-title":"PHF8, a gene associated with cleft lip\/palate and mental retardation, encodes for an N\u03b5-dimethyl lysine demethylase","volume":"19","author":"Loenarz","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"2024061301021181200_DEV175042C49","doi-asserted-by":"publisher","first-page":"11359","DOI":"10.1523\/JNEUROSCI.2247-06.2006","article-title":"The transcriptional coactivator Querkopf controls adult neurogenesis","volume":"26","author":"Merson","year":"2006","journal-title":"J. Neurosci."},{"key":"2024061301021181200_DEV175042C50","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1002\/ajmg.a.37670","article-title":"Whole exome sequencing reveals de novo pathogenic variants in KAT6A as a cause of a neurodevelopmental disorder","volume":"170","author":"Millan","year":"2016","journal-title":"Am. J. Med. Genet. A"},{"key":"2024061301021181200_DEV175042C51","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1242\/dev.01134","article-title":"moz regulates Hox expression and pharyngeal segmental identity in zebrafish","volume":"131","author":"Miller","year":"2004","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C52","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1016\/j.celrep.2016.08.056","article-title":"Acetylation of the Cd8 locus by KAT6A determines memory T cell diversity","volume":"16","author":"Newman","year":"2016","journal-title":"Cell Rep."},{"key":"2024061301021181200_DEV175042C53","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S0092-8674(00)80259-7","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto","year":"1997","journal-title":"Cell"},{"key":"2024061301021181200_DEV175042C54","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1101\/gad.12.17.2735","article-title":"Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities","volume":"12","author":"Peters","year":"1998","journal-title":"Genes Dev."},{"key":"2024061301021181200_DEV175042C55","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1214\/16-AOAS920","article-title":"Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression","volume":"10","author":"Phipson","year":"2016","journal-title":"Ann. Appl. Stat."},{"key":"2024061301021181200_DEV175042C56","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1101\/gad.9.20.2523","article-title":"Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain","volume":"9","author":"Qiu","year":"1995","journal-title":"Genes Dev."},{"key":"2024061301021181200_DEV175042C57","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1006\/dbio.1997.8556","article-title":"Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and \u22122 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches","volume":"185","author":"Qiu","year":"1997","journal-title":"Dev. Biol."},{"key":"2024061301021181200_DEV175042C58","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nature01178","article-title":"Human chromosome 21 gene expression atlas in the mouse","volume":"420","author":"Reymond","year":"2002","journal-title":"Nature"},{"key":"2024061301021181200_DEV175042C59","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2024061301021181200_DEV175042C60","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol."},{"key":"2024061301021181200_DEV175042C61","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2024061301021181200_DEV175042C62","doi-asserted-by":"publisher","first-page":"5437","DOI":"10.1073\/pnas.1422872112","article-title":"MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo","volume":"112","author":"Sheikh","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061301021181200_DEV175042C63","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1182\/blood-2014-08-594655","article-title":"MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development","volume":"125","author":"Sheikh","year":"2015","journal-title":"Blood"},{"key":"2024061301021181200_DEV175042C64","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1038\/onc.2015.33","article-title":"MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway","volume":"34","author":"Sheikh","year":"2015","journal-title":"Oncogene"},{"key":"2024061301021181200_DEV175042C65","doi-asserted-by":"publisher","first-page":"blood-2015-10-676072","DOI":"10.1182\/blood-2015-10-676072","article-title":"MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells","author":"Sheikh","year":"2016","journal-title":"Blood"},{"key":"2024061301021181200_DEV175042C66","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen structure and stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"2024061301021181200_DEV175042C67","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/jmg.36.5.353","article-title":"Clinical and Molecular genetics of Stickler syndrome","volume":"36","author":"Snead","year":"1999","journal-title":"J. Med. Genet."},{"key":"2024061301021181200_DEV175042C68","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1002\/dvdy.24156","article-title":"The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal development","volume":"243","author":"Sperry","year":"2014","journal-title":"Dev. Dyn."},{"key":"2024061301021181200_DEV175042C69","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1006\/dbio.2002.0640","article-title":"Role of Runx genes in chondrocyte differentiation","volume":"245","author":"Stricker","year":"2002","journal-title":"Dev. Biol."},{"key":"2024061301021181200_DEV175042C70","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1242\/dev.128793","article-title":"Genetic analysis of Runx2 function during intramembranous ossification","volume":"143","author":"Takarada","year":"2016","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C71","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.ajhg.2015.01.016","article-title":"Dominant mutations in KAT6A cause intellectual disability with recognizable syndromic features","volume":"96","author":"Tham","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"2024061301021181200_DEV175042C72","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.127.12.2537","article-title":"Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development","volume":"127","author":"Thomas","year":"2000","journal-title":"Development"},{"key":"2024061301021181200_DEV175042C73","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1101\/gad.1382606","article-title":"Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells","volume":"20","author":"Thomas","year":"2006","journal-title":"Genes Dev."},{"key":"2024061301021181200_DEV175042C74","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.modgep.2007.03.005","article-title":"The genes coding for the MYST family histone acetyltransferases, Tip60 and Mof, are expressed at high levels during sperm development","volume":"7","author":"Thomas","year":"2007","journal-title":"Gene Expr. Patterns"},{"key":"2024061301021181200_DEV175042C75","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1002\/ajmg.a.36450","article-title":"De novo ANKRD11 and KDM1A gene mutations in a male with features of KBG syndrome and Kabuki syndrome","volume":"164","author":"Tunovic","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"2024061301021181200_DEV175042C76","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ydbio.2015.04.011","article-title":"Mesodermal expression of Moz is necessary for cardiac septum development","volume":"403","author":"Vanyai","year":"2015","journal-title":"Dev. Biol."},{"key":"2024061301021181200_DEV175042C77","doi-asserted-by":"publisher","first-page":"21372","DOI":"10.1074\/jbc.M111.252031","article-title":"Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression","volume":"286","author":"Venugopalan","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2024061301021181200_DEV175042C78","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.devcel.2007.03.007","article-title":"The transcription factor MEF2C is required for craniofacial development","volume":"12","author":"Verzi","year":"2007","journal-title":"Dev. Cell"},{"key":"2024061301021181200_DEV175042C79","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.devcel.2009.10.006","article-title":"Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity","volume":"17","author":"Voss","year":"2009","journal-title":"Dev. Cell"},{"key":"2024061301021181200_DEV175042C80","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.devcel.2012.07.010","article-title":"MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome","volume":"23","author":"Voss","year":"2012","journal-title":"Dev. Cell"},{"key":"2024061301021181200_DEV175042C81","first-page":"176","article-title":"Closure of the secondary palate in three strains of mice","volume":"4","author":"Walker","year":"1956","journal-title":"J. Embryol. Exp. Morphol."},{"key":"2024061301021181200_DEV175042C82","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1093\/bioinformatics\/btq401","article-title":"ROAST: rotation gene set tests for complex microarray experiments","volume":"26","author":"Wu","year":"2010","journal-title":"Bioinformatics"},{"key":"2024061301021181200_DEV175042C83","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.1093\/hmg\/ddv167","article-title":"DLX4 is associated with orofacial clefting and abnormal jaw development","volume":"24","author":"Wu","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2024061301021181200_DEV175042C84","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1002\/dvdy.22670","article-title":"Histomorphological study of palatal shelf elevation during murine secondary palate formation","volume":"240","author":"Yu","year":"2011","journal-title":"Dev. Dyn."},{"key":"2024061301021181200_DEV175042C85","doi-asserted-by":"publisher","first-page":"19004","DOI":"10.1073\/pnas.0605170103","article-title":"Dominance of SOX9 function over RUNX2 during skeletogenesis","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.175042","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.175042\/3480237\/dev175042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.175042\/3480237\/dev175042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T01:02:52Z","timestamp":1718240572000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/146\/14\/dev175042\/48936\/MOZ-directs-the-distal-less-homeobox-gene"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":85,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.175042","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,15]]},"article-number":"dev175042"}}