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Here, we used loss-of-function (Eda\u2212\/\u2212) mutant mice to unravel the impact of Eda signaling on lacrimal gland formation, maturation and subsequent physiological function. Our study demonstrates that Eda activity is dispensable during lacrimal gland embryonic development. However, using a transcriptomic approach, we show that the Eda pathway is necessary for proper cell terminal differentiation in lacrimal gland epithelium and correlated with modified expression of secreted factors commonly found in the tear film. Finally, we discovered that lacrimal glands present a bilateral reduction of Eda signaling activity in response to unilateral corneal injury. This observation hints towards a role for the Eda pathway in controlling the switch from basal to reflex tears, to support corneal wound healing. Collectively, our data suggest a crucial implication of Eda signaling in the cornea\u2013lacrimal gland feedback loop, both in physiological and pathophysiological conditions. Our findings demonstrate that Eda downstream targets could help alleviate dry eye symptoms.<\/jats:p>","DOI":"10.1242\/dev.176693","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T14:15:16Z","timestamp":1561040116000},"source":"Crossref","is-referenced-by-count":24,"title":["Ectodysplasin-A signaling is a key integrator in the lacrimal gland\u2013cornea feedback loop"],"prefix":"10.1242","volume":"146","author":[{"given":"Alison","family":"Kuony","sequence":"first","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Science, Developmental Biology Program, University of Helsinki 1 , 00790 Helsinki , Finland"},{"name":"Institut Jacques Monod, Universit\u00e9 Denis Diderot - Paris 7, CNRS UMR 7592, Buffon building 2 , 15 rue H\u00e9l\u00e8ne Brion, 75205 Paris Cedex 13 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisa","family":"Ikkala","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Science, Developmental Biology Program, University of Helsinki 1 , 00790 Helsinki , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solja","family":"Kalha","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Science, Developmental Biology Program, University of Helsinki 1 , 00790 Helsinki , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cathia","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Science, Developmental Biology Program, University of Helsinki 1 , 00790 Helsinki , Finland"},{"name":"Institute for Neurosciences of Montpellier, INSERM UMR1051, University of Montpellier 3 , 34295 Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anniina","family":"Pirttiniemi","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Science, Developmental Biology Program, University of Helsinki 1 , 00790 Helsinki , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4305-305X","authenticated-orcid":false,"given":"Frederic","family":"Michon","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Science, Developmental Biology Program, University of Helsinki 1 , 00790 Helsinki , Finland"},{"name":"Institute for Neurosciences of Montpellier, INSERM UMR1051, University of Montpellier 3 , 34295 Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"2024061301015938400_DEV176693C1","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1093\/hmg\/7.11.1661","article-title":"The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-a with deletion mutations in collagenous repeats","volume":"7","author":"Bay\u00e9s","year":"1998","journal-title":"Hum. 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