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For example, degeneration of retinal ganglion cell (RGC) axons in glaucoma leads to irreversible loss of vision. Here, we have tested the hypothesis that the mTOR pathway regulates the development of human RGCs and that its recruitment after injury facilitates axon regeneration. We observed that the mTOR pathway is active during RGC differentiation, and using the induced pluripotent stem cell model of neurogenesis show that it facilitates the differentiation, function and neuritogenesis of human RGCs. Using a microfluidic model, we demonstrate that recruitment of the mTOR pathway facilitates human RGC axon regeneration after axotomy, providing evidence that the recapitulation of developmental mechanism(s) might be a viable approach for facilitating axon regeneration in the diseased or injured human CNS, thus helping to reduce and\/or recover loss of function.<\/jats:p>","DOI":"10.1242\/dev.178012","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T15:08:30Z","timestamp":1562252910000},"source":"Crossref","is-referenced-by-count":48,"title":["Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway"],"prefix":"10.1242","volume":"146","author":[{"given":"Pooja","family":"Teotia","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Van Hook","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology, Ruhr University of Bochum, Universit\u00e4tsstra\u00dfe 150, 44780 Bochum, Germany"},{"name":"Division of Experimental Neurology, Medical Faculty, Heinrich Heine University, Merowingerplatz 1a, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-9835","authenticated-orcid":false,"given":"Iqbal","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"2021042512410052500_DEV178012C1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. 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