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Several adhesion molecules are known to be important for dendrite self-avoidance, but the underlying molecular mechanisms are incompletely defined. Here, we show that FMI-1\/Flamingo, an atypical cadherin, is required autonomously for self-avoidance in the multidendritic PVD neuron of Caenorhabditis elegans. The fmi-1 mutant shows increased crossover between sister PVD dendrites. Our genetic analysis suggests that FMI-1 promotes transient F-actin assembly at the tips of contacting sister dendrites to facilitate their efficient retraction during self-avoidance events, probably by interacting with WSP-1\/N-WASP. Mutations of vang-1, which encodes the planar cell polarity protein Vangl2 previously shown to inhibit F-actin assembly, suppress self-avoidance defects of the fmi-1 mutant. FMI-1 downregulates VANG-1 levels probably through forming protein complexes. Our study identifies molecular links between Flamingo and the F-actin cytoskeleton that facilitate efficient dendrite self-avoidance.<\/jats:p>","DOI":"10.1242\/dev.179168","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T17:55:13Z","timestamp":1594058113000},"source":"Crossref","is-referenced-by-count":15,"title":["<i>Caenorhabditis elegans<\/i> Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly"],"prefix":"10.1242","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-3256","authenticated-orcid":false,"given":"Hao-Wei","family":"Hsu","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University , Taipei 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Po","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University , Taipei 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Chen","family":"Chiang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University , Taipei 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-4885","authenticated-orcid":false,"given":"Ru-Ting","family":"Syu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University , Taipei 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-3138","authenticated-orcid":false,"given":"Chun-Liang","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Center of Precision Medicine, College of Medicine, National Taiwan University , Taipei 10002 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"2024061301354818000_DEV179168C1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.mcn.2010.10.001","article-title":"C. elegans multi-dendritic sensory neurons: morphology and function","volume":"46","author":"Albeg","year":"2011","journal-title":"Mol. 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