{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:10:25Z","timestamp":1791511825245,"version":"4.3.4"},"reference-count":213,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["BB\/P000444\/1"],"award-info":[{"award-number":["BB\/P000444\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"crossref","award":["824070"],"award-info":[{"award-number":["824070"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011692","name":"Children's Cancer and Leukaemia Group","doi-asserted-by":"crossref","award":["MR\/V002163\/1"],"award-info":[{"award-number":["MR\/V002163\/1"]}],"id":[{"id":"10.13039\/100011692","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008634","name":"Neuroblastoma UK","doi-asserted-by":"crossref","award":["CCLGA 2019 28"],"award-info":[{"award-number":["CCLGA 2019 28"]}],"id":[{"id":"10.13039\/501100008634","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["MR\/S008799\/1"],"award-info":[{"award-number":["MR\/S008799\/1"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP19K16157"],"award-info":[{"award-number":["JP19K16157"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The generation of the components that make up the embryonic body axis, such as the spinal cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction. This process is driven by the coordinated production of various cell types from a pool of posteriorly-located axial progenitors. Here, we review the key features of this process and the biology of axial progenitors, including neuromesodermal progenitors, the common precursors of the spinal cord and trunk musculature. We discuss recent developments in the in vitro production of axial progenitors and their potential implications in disease modelling and regenerative medicine.<\/jats:p>","DOI":"10.1242\/dev.180612","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T13:54:11Z","timestamp":1613483651000},"source":"Crossref","is-referenced-by-count":129,"title":["Understanding axial progenitor biology <i>in vivo<\/i> and <i>in vitro<\/i>"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-4555","authenticated-orcid":false,"given":"Filip J.","family":"Wymeersch","sequence":"first","affiliation":[{"name":"Laboratory for Human Organogenesis, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-5159","authenticated-orcid":false,"given":"Valerie","family":"Wilson","sequence":"additional","affiliation":[{"name":"Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2184-2990","authenticated-orcid":false,"given":"Anestis","family":"Tsakiridis","sequence":"additional","affiliation":[{"name":"Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield S10 2TNUK"},{"name":"Neuroscience Institute, The University of Sheffield, Western Bank, Sheffield, S10 2TNUK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"2021042701111007800_DEV180612C1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.stemcr.2017.11.003","article-title":"Generation of adrenal chromaffin-like cells from human pluripotent stem cells","volume":"10","author":"Abu-Bonsrah","year":"2018","journal-title":"Stem Cell Reports"},{"key":"2021042701111007800_DEV180612C2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/bdra.23163","article-title":"Exon sequencing of PAX3 and T (brachyury) in cases with spina bifida","volume":"97","author":"Agopian","year":"2013","journal-title":"Birth Defects Res. 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