{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:03:31Z","timestamp":1753884211983,"version":"3.41.2"},"reference-count":1,"publisher":"The Company of Biologists","issue":"13","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Transcriptional autoregulation occurs when transcription factors bind their own cis-regulatory sequences, ensuring their own continuous expression along with expression of other targets. During development, continued expression of identity-specifying transcription factors can be achieved by autoregulation, but until now formal evidence for a developmental requirement of autoregulation has been lacking. A new paper in Development provides this proof with the help of CRISPR\/Cas9 gene editing in the C. elegans nervous system. We caught up with the paper's two authors: postdoc Eduardo Leyva-D\u00edaz and his supervisor Oliver Hobert, Professor of Biological Sciences and HHMI Investigator at Columbia University, New York, to find out more about the work.<\/jats:p>","DOI":"10.1242\/dev.180869","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T15:45:47Z","timestamp":1561131947000},"source":"Crossref","is-referenced-by-count":0,"title":["The people behind the papers \u2013 Eduardo Leyva-D\u00edaz and Oliver Hobert"],"prefix":"10.1242","volume":"146","member":"237","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"2021042512414143400_DEV180869C1","doi-asserted-by":"publisher","first-page":"dev177378","DOI":"10.1242\/dev.177378","article-title":"Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity","volume":"146","author":"Leyva-D\u00edaz","year":"2019","journal-title":"Development"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.180869\/1857619\/dev180869.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.180869\/1857619\/dev180869.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T14:14:34Z","timestamp":1619360074000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/146\/13\/dev180869\/19844\/The-people-behind-the-papers-Eduardo-Leyva-Diaz"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,21]]},"references-count":1,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.180869","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"type":"electronic","value":"1477-9129"},{"type":"print","value":"0950-1991"}],"subject":[],"published":{"date-parts":[[2019,6,21]]},"article-number":"dev180869"}}