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The field of regenerative biology has grown steadily over the past decade, incorporating advances in imaging, genomics and genome editing to identify key cell types and molecules involved across many model organisms. Yet for many or most tissues, it can be difficult to predict when and how findings from these studies will advance regenerative medicine. Establishing technologies to stimulate regrowth of a lost or amputated limb with a patterned replicate, as salamanders do routinely, is one of the most challenging directives of tissue regeneration research. Here, we speculate upon what research avenues the field must explore to move closer to this capstone achievement.<\/jats:p>","DOI":"10.1242\/dev.181016","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T13:05:14Z","timestamp":1570021514000},"source":"Crossref","is-referenced-by-count":21,"title":["Can laboratory model systems instruct human limb regeneration?"],"prefix":"10.1242","volume":"146","author":[{"given":"Ben D.","family":"Cox","sequence":"first","affiliation":[{"name":"Regeneration Next, Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-2453","authenticated-orcid":false,"given":"Maximina H.","family":"Yun","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t Dresden, CRTD\/Center for Regenerative Therapies Dresden, Dresden 01307, Germany"},{"name":"Max Planck Institute for Molecular Cell Biology and Genetics, Dresden 01307, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Poss","sequence":"additional","affiliation":[{"name":"Regeneration Next, Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,10,2]]},"reference":[{"key":"2021042623491600500_DEV181016C1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1126\/science.aau1549","article-title":"Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy","volume":"362","author":"Amoasii","year":"2018","journal-title":"Science"},{"key":"2021042623491600500_DEV181016C2","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.devcel.2017.10.015","article-title":"Osteoblast production by reserved progenitor cells in zebrafish bone regeneration and maintenance","volume":"43","author":"Ando","year":"2017","journal-title":"Dev. 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