{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:07:23Z","timestamp":1791857243577,"version":"4.3.4"},"reference-count":67,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL120142"],"award-info":[{"award-number":["HL120142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CMMI-1435853"],"award-info":[{"award-number":["CMMI-1435853"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>During branching morphogenesis, a simple cluster of cells proliferates and branches to generate an arborized network that facilitates fluid flow. The overall architecture of the mouse lung is established by domain branching, wherein new branches form laterally off the side of an existing branch. The airway epithelium develops concomitantly with a layer of smooth muscle that is derived from the embryonic mesenchyme. Here, we examined the role of smooth muscle differentiation in shaping emerging domain branches. We found that the position and morphology of domain branches are highly stereotyped, as is the pattern of smooth muscle that differentiates around the base of each branch. Perturbing the pattern of smooth muscle differentiation genetically or pharmacologically causes abnormal domain branching. Loss of smooth muscle results in ectopic branching and decreases branch stereotypy. Increased smooth muscle suppresses branch initiation and extension. Computational modeling revealed that epithelial proliferation is insufficient to generate domain branches and that smooth muscle wrapping is required to shape the epithelium into a branch. Our work sheds light on the physical mechanisms of branching morphogenesis in the mouse lung.<\/jats:p>","DOI":"10.1242\/dev.181172","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T14:40:39Z","timestamp":1571841639000},"source":"Crossref","is-referenced-by-count":74,"title":["Smooth muscle differentiation shapes domain branches during mouse lung development"],"prefix":"10.1242","author":[{"given":"Katharine","family":"Goodwin","sequence":"first","affiliation":[{"name":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Guyomar","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, 08544, USA"},{"name":"D\u00e9partement de Physique, Ecole Normale Sup\u00e9rieure de Lyon, F-69342 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek C.","family":"Radisky","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Ko\u0161mrlj","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9973-8870","authenticated-orcid":false,"given":"Celeste M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA"},{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"2021042622572523300_DEV181172C1","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1002\/dvdy.22032","article-title":"Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung","volume":"238","author":"Abler","year":"2009","journal-title":"Dev. 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