{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:33:52Z","timestamp":1790274832934,"version":"4.1.0"},"reference-count":66,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1348 B5"],"award-info":[{"award-number":["SFB 1348 B5"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The development of tissues and organs requires close interaction of cells. To achieve this, cells express adhesion proteins such as the neural cell adhesion molecule (NCAM) or its Drosophila ortholog Fasciclin 2 (Fas2). Both are members of the Ig-domain superfamily of proteins that mediate homophilic adhesion. These proteins are expressed as isoforms differing in their membrane anchorage and their cytoplasmic domains. To study the function of single isoforms, we have conducted a comprehensive genetic analysis of Fas2. We reveal the expression pattern of all major Fas2 isoforms, two of which are GPI anchored. The remaining five isoforms carry transmembrane domains with variable cytoplasmic tails. We generated Fas2 mutants expressing only single isoforms. In contrast to the null mutation, which causes embryonic lethality, these mutants are viable, indicating redundancy among the different isoforms. Cell type-specific rescue experiments showed that glial-secreted Fas2 can rescue the Fas2 mutant phenotype to viability. This demonstrates that cytoplasmic Fas2 domains have no apparent essential functions and indicate that Fas2 has function(s) other than homophilic adhesion. In conclusion, our data suggest novel mechanistic aspects of a long-studied adhesion protein.<\/jats:p>","DOI":"10.1242\/dev.181479","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T16:35:16Z","timestamp":1576859716000},"source":"Crossref","is-referenced-by-count":27,"title":["The\n                    <i>Drosophila<\/i>\n                    NCAM homolog Fas2 signals independently of adhesion"],"prefix":"10.1242","volume":"147","author":[{"given":"Helen","family":"Neuert","sequence":"first","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Deing","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Krukkert","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Naffin","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Steffes","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Risse","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Silies","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-5800","authenticated-orcid":false,"given":"Christian","family":"Kl\u00e4mbt","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster, Institute for Neuro- and Behavioral Biology , Badestrasse 9, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"2024061301115937300_DEV181479C1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.celrep.2013.06.020","article-title":"Highly efficient targeted mutagenesis of Drosophila with the CRISPR\/Cas9 system","volume":"4","author":"Bassett","year":"2013","journal-title":"Cell Rep."},{"key":"2024061301115937300_DEV181479C2","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0092-8674(89)90029-9","article-title":"Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1","volume":"59","author":"Bieber","year":"1989","journal-title":"Cell"},{"key":"2024061301115937300_DEV181479C3","doi-asserted-by":"publisher","first-page":"3312","DOI":"10.1073\/pnas.0611511104","article-title":"An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases","volume":"104","author":"Bischof","year":"2007","journal-title":"Proc. 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