{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:04:02Z","timestamp":1753884242600,"version":"3.41.2"},"reference-count":46,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"the Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB19000000"],"award-info":[{"award-number":["XDB19000000"]}]},{"DOI":"10.13039\/501100012166","name":"National key Research & Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0107900"],"award-info":[{"award-number":["2018YFA0107900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["31730112"],"award-info":[{"award-number":["31730112"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["31501172"],"award-info":[{"award-number":["31501172"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["31801215"],"award-info":[{"award-number":["31801215"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Program for Guangdong Introducing Innovative and Entrepreneurial Teams","award":["2017ZT07S347"],"award-info":[{"award-number":["2017ZT07S347"]}]},{"name":"Key Project of Frontier Sciences of CAS","award":["QYZDB-SSW-SMC003"],"award-info":[{"award-number":["QYZDB-SSW-SMC003"]}]},{"name":"Shanghai Science and Technology Commission","award":["17ZR1449600"],"award-info":[{"award-number":["17ZR1449600"]}]},{"name":"Shanghai Yangfan Project","award":["16YF1413400"],"award-info":[{"award-number":["16YF1413400"]}]},{"name":"Rising-Star Program","award":["15QA1404300"],"award-info":[{"award-number":["15QA1404300"]}]},{"name":"ok"},{"name":"Astrazeneca, Boehringer Ingelheim, Sanofi-SIBS Fellowship, and Royal Society-Newton Advanced Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cellular proliferation is a basic process during organ development, tissue homeostasis, and\/or disease progression. Likewise, after injury typically multiple cell lineages respond to various cues and proliferate to initiate repair and\/or remodeling of the injured tissue. Unravelling the specific role of proliferation of one cell type and its lineage in the context of the whole organism during tissue regeneration and\/or disease progression would provide valuable information on these processes. Here we reported a new genetic system to inhibit cell proliferation in a tissue-specific manner. We generated Cre- or Dre-inducible p21-GFP (ip21-GFP) transgenic mice that allow for the experimentally-induced permanent cell cycle arrest of specific cell lineages of interest, while genetically marking these cells. This system allows for the inhibition of pathogenic cell proliferation. We found that cardiac fibroblast proliferation inhibition significantly reduced scar formation, and promoted neovascularization and cardiomyocyte survival. Additionally, we found that inhibition of one type of cell proliferation (namely, hepatocytes) induces the lineage conversion of another type cells (ie, ductal cells) during tissue regeneration. These results validate the use of ip21-GFP mice as a new genetic tool for cell lineage-specific inhibition of cell proliferation in vivo.<\/jats:p>","DOI":"10.1242\/dev.183830","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T15:35:15Z","timestamp":1580139315000},"source":"Crossref","is-referenced-by-count":11,"title":["A genetic system for tissue-specific inhibition of cell proliferation"],"prefix":"10.1242","author":[{"given":"Wenjuan","family":"Pu","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China"},{"name":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 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Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China"},{"name":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhen","family":"Huang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of 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Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-4452","authenticated-orcid":false,"given":"Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China"},{"name":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqing","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center for Model Organisms, Shanghai Model Organisms Center, Inc. (SMOC), Shanghai, 201203, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruilin","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center for Model Organisms, Shanghai Model Organisms Center, Inc. (SMOC), Shanghai, 201203, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Fei","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center for Model Organisms, Shanghai Model Organisms Center, Inc. (SMOC), Shanghai, 201203, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Ji","sequence":"additional","affiliation":[{"name":"The Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China"},{"name":"Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Nie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-5522","authenticated-orcid":false,"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Cell Biology, CAS Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China"},{"name":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China"},{"name":"School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China"},{"name":"Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China"},{"name":"The Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 211100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042623015209100_DEV183830C1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1242\/dmm.003087","article-title":"Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice","volume":"2","author":"Anastassiadis","year":"2009","journal-title":"Dis. 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