{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T22:20:55Z","timestamp":1767046855050,"version":"3.41.2"},"reference-count":62,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY029267"],"award-info":[{"award-number":["R01EY029267"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The development of the biliary system is a complex yet poorly understood process, with relevance to multiple diseases including biliary atresia, choledochal cysts, and gallbladder agenesis. We present here a crucial role for Hippo-Yap\/Taz signaling in this context. Analysis of sav1 mutant zebrafish revealed dysplastic morphology and expansion of both intrahepatic and extrahepatic biliary cells, and ultimately larval lethality. Biliary dysgenesis, but not larval lethality, is driven primarily by Yap signaling. Re-expression of Sav1 protein in sav1\u2212\/\u2212 hepatocytes is able to overcome these initial deficits and allow sav1\u2212\/\u2212 fish to survive, suggesting cell non-autonomous signaling from hepatocytes. Examination of sav1\u2212\/\u2212 rescued adults reveals loss of gallbladder and formation of dysplastic cell masses expressing biliary markers suggesting roles for Hippo signaling in extrahepatic biliary carcinomas. Deletion of stk3 revealed the phenotypes observed in sav1 mutant fish function primarily through canonical Hippo signaling and supports a role for phosphatase PP2A, but also suggests Sav1 has functions in addition to facilitating Stk3 activity. Overall, this study defines a role for Hippo-Yap signaling in the maintenance of both intra- and extrahepatic biliary ducts.<\/jats:p>","DOI":"10.1242\/dev.184242","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T20:15:19Z","timestamp":1590092119000},"source":"Crossref","is-referenced-by-count":5,"title":["Core Hippo pathway components act as a brake on Yap\/Taz in the development and maintenance of the biliary network"],"prefix":"10.1242","author":[{"given":"Zachary J.","family":"Brandt","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley E.","family":"Echert","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Bostrom","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula N.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pathology, Medical College of Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-2642","authenticated-orcid":false,"given":"Brian A.","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042623454678300_DEV184242C1","doi-asserted-by":"publisher","first-page":"e30278","DOI":"10.7554\/eLife.30278","article-title":"SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK","volume":"6","author":"Bae","year":"2017","journal-title":"eLife"},{"key":"2021042623454678300_DEV184242C2","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1101\/gad.1938710","article-title":"Nf2\/Merlin controls progenitor homeostasis and tumorigenesis in the liver","volume":"24","author":"Benhamouche","year":"2010","journal-title":"Genes Dev."},{"key":"2021042623454678300_DEV184242C3","doi-asserted-by":"publisher","first-page":"5532","DOI":"10.1074\/jbc.RA117.000923","article-title":"Salvador has an extended SARAH domain that mediates binding to Hippo kinase","volume":"293","author":"Cairns","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2021042623454678300_DEV184242C4","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr. Biol."},{"key":"2021042623454678300_DEV184242C5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"2021042623454678300_DEV184242C6","doi-asserted-by":"publisher","first-page":"e0151521","DOI":"10.1371\/journal.pone.0151521","article-title":"Methylation microarray studies highlight PDGFA expression as a factor in biliary atresia","volume":"11","author":"Cofer","year":"2016","journal-title":"PLoS ONE"},{"key":"2021042623454678300_DEV184242C7","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/ncb3389","article-title":"Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth","volume":"18","author":"Cox","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"2021042623454678300_DEV184242C8","doi-asserted-by":"publisher","first-page":"e100294","DOI":"10.15252\/embj.2018100294","article-title":"Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth","volume":"37","author":"Cox","year":"2018","journal-title":"EMBO J."},{"key":"2021042623454678300_DEV184242C9","doi-asserted-by":"publisher","first-page":"e1002754","DOI":"10.1371\/journal.pgen.1002754","article-title":"sox9b is a key regulator of pancreaticobiliary ductal system development","volume":"8","author":"Delous","year":"2012","journal-title":"PLoS Genet."},{"key":"2021042623454678300_DEV184242C10","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/j.bbadis.2017.08.021","article-title":"Bile acid receptors in the biliary tree: TGR5 in physiology and disease","volume":"1864","author":"Deutschmann","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"2021042623454678300_DEV184242C11","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/ng1961","article-title":"Fgf10 regulates hepatopancreatic ductal system patterning and differentiation","volume":"39","author":"Dong","year":"2007","journal-title":"Nat. Genet."},{"key":"2021042623454678300_DEV184242C12","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1002\/hep.29632","article-title":"Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency","volume":"67","author":"Ellis","year":"2018","journal-title":"Hepatology"},{"key":"2021042623454678300_DEV184242C13","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.6273er1","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal"},{"key":"2021042623454678300_DEV184242C14","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1093\/jmcb\/mjy068","article-title":"Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1","volume":"11","author":"Gao","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"2021042623454678300_DEV184242C15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ncb1339","article-title":"The tumour-suppressor genes NF2\/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis","volume":"8","author":"Hamaratoglu","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"2021042623454678300_DEV184242C16","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0014-5793(03)00157-1","article-title":"In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio)","volume":"538","author":"Her","year":"2003","journal-title":"FEBS Lett."},{"key":"2021042623454678300_DEV184242C17","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1080\/15384047.2015.1040961","article-title":"LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential","volume":"16","author":"Hong","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"2021042623454678300_DEV184242C18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.suc.2014.01.001","article-title":"Anatomy and embryology of the biliary tract","volume":"94","author":"Keplinger","year":"2014","journal-title":"Surgical Clinics of North America"},{"key":"2021042623454678300_DEV184242C19","doi-asserted-by":"publisher","first-page":"e31065","DOI":"10.7554\/eLife.31065","article-title":"Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1","volume":"6","author":"Kimelman","year":"2017","journal-title":"eLife"},{"key":"2021042623454678300_DEV184242C20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1053\/j.gastro.2018.09.039","article-title":"Hdac1 regulates differentiation of bipotent liver progenitor cells during regeneration via Sox9b and Cdk8","volume":"156","author":"Ko","year":"2019","journal-title":"Gastroenterology"},{"key":"2021042623454678300_DEV184242C21","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.1002\/dvdy.21343","article-title":"The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs","volume":"236","author":"Kwan","year":"2007","journal-title":"Dev. Dyn."},{"key":"2021042623454678300_DEV184242C22","doi-asserted-by":"publisher","first-page":"dev159210","DOI":"10.1242\/dev.159210","article-title":"The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish","volume":"145","author":"Lai","year":"2018","journal-title":"Development"},{"key":"2021042623454678300_DEV184242C23","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/emboj.2008.63","article-title":"A crucial role of WW45 in developing epithelial tissues in the mouse","volume":"27","author":"Lee","year":"2008","journal-title":"EMBO J."},{"key":"2021042623454678300_DEV184242C24","doi-asserted-by":"publisher","first-page":"8248","DOI":"10.1073\/pnas.0912203107","article-title":"The Hippo\u2013Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis","volume":"107","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042623454678300_DEV184242C25","doi-asserted-by":"publisher","first-page":"11961","DOI":"10.1038\/ncomms11961","article-title":"LATS-YAP\/TAZ controls lineage specification by regulating TGF\u03b2 signaling and Hnf4\u03b1 expression during liver development","volume":"7","author":"Lee","year":"2016","journal-title":"Nat. Commun."},{"year":"2019","author":"Lemaigre","key":"2021042623454678300_DEV184242C26"},{"key":"2021042623454678300_DEV184242C27","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1038\/s41467-019-09597-w","article-title":"Identification of the kinase STK25 as an upstream activator of LATS signaling","volume":"10","author":"Lim","year":"2019","journal-title":"Nat. Commun."},{"key":"2021042623454678300_DEV184242C28","doi-asserted-by":"publisher","first-page":"5753","DOI":"10.1242\/dev.01411","article-title":"Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy","volume":"131","author":"Lorent","year":"2004","journal-title":"Development"},{"key":"2021042623454678300_DEV184242C29","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/dvdy.22220","article-title":"Reiterative use of the notch signal during zebrafish intrahepatic biliary development","volume":"239","author":"Lorent","year":"2010","journal-title":"Dev. Dyn."},{"key":"2021042623454678300_DEV184242C30","doi-asserted-by":"publisher","first-page":"286ra67","DOI":"10.1126\/scitranslmed.aaa1652","article-title":"Identification of a plant isoflavonoid that causes biliary atresia","volume":"7","author":"Lorent","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"2021042623454678300_DEV184242C31","doi-asserted-by":"publisher","first-page":"11697","DOI":"10.1073\/pnas.0905930106","article-title":"Inhibition of serine\/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms","volume":"106","author":"Lu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042623454678300_DEV184242C32","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1073\/pnas.0911427107","article-title":"Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver","volume":"107","author":"Lu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042623454678300_DEV184242C33","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ydbio.2012.04.002","article-title":"Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration","volume":"366","author":"Manfroid","year":"2012","journal-title":"Dev. Biol."},{"key":"2021042623454678300_DEV184242C34","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00033","article-title":"Hippo signaling in the liver \u2013 a long and ever-expanding story","volume":"7","author":"Manmadhan","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"2021042623454678300_DEV184242C35","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mam.2017.01.006","article-title":"Bile acids and their receptors","volume":"56","author":"Martinot","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"2021042623454678300_DEV184242C36","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1101\/gad.12.8.1121","article-title":"Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors","volume":"12","author":"McClatchey","year":"1998","journal-title":"Genes Dev."},{"key":"2021042623454678300_DEV184242C37","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1038\/sj.emboj.7600371","article-title":"Lats2\/Kpm is required for embryonic development, proliferation control and genomic integrity","volume":"23","author":"McPherson","year":"2004","journal-title":"EMBO J."},{"key":"2021042623454678300_DEV184242C38","doi-asserted-by":"publisher","first-page":"8357","DOI":"10.1038\/ncomms9357","article-title":"MAP4K family kinases act in parallel to MST1\/2 to activate LATS1\/2 in the Hippo pathway","volume":"6","author":"Meng","year":"2015","journal-title":"Nat. Commun."},{"key":"2021042623454678300_DEV184242C39","doi-asserted-by":"publisher","first-page":"e8985","DOI":"10.15252\/msb.20198985","article-title":"Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration","volume":"16","author":"Meyer","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"2021042623454678300_DEV184242C40","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1242\/dev.119008","article-title":"Yap and Taz regulate retinal pigment epithelial cell fate","volume":"142","author":"Miesfeld","year":"2015","journal-title":"Development"},{"key":"2021042623454678300_DEV184242C41","doi-asserted-by":"publisher","first-page":"E71","DOI":"10.1073\/pnas.1517188113","article-title":"Dysregulated YAP1\/TAZ and TGF-\u03b2 signaling mediate hepatocarcinogenesis in Mob1a\/1b-deficient mice","volume":"113","author":"Nishio","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042623454678300_DEV184242C42","doi-asserted-by":"publisher","first-page":"6309","DOI":"10.1128\/MCB.00551-09","article-title":"Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse","volume":"29","author":"Oh","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"2021042623454678300_DEV184242C43","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.stem.2019.04.004","article-title":"Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration","volume":"25","author":"Pepe-Mooney","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2021042623454678300_DEV184242C44","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-4939-9420-5_18","article-title":"Zebrafish as a model to study cholestatic liver diseases","volume-title":"Experimental Cholestasis Research","author":"Pham","year":"2019"},{"key":"2021042623454678300_DEV184242C45","doi-asserted-by":"publisher","first-page":"8451282","DOI":"10.1155\/2019\/8451282","article-title":"Notch inhibition promotes differentiation of liver progenitor cells into hepatocytes via sox9b repression in zebrafish","volume":"2019","author":"Russell","year":"2019","journal-title":"Stem Cells Int."},{"key":"2021042623454678300_DEV184242C46","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1242\/dev.01918","article-title":"A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease","volume":"132","author":"Sadler","year":"2005","journal-title":"Development"},{"key":"2021042623454678300_DEV184242C47","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.cub.2008.08.065","article-title":"Endothelial signals modulate hepatocyte apicobasal polarization in zebrafish","volume":"18","author":"Sakaguchi","year":"2008","journal-title":"Curr. Biol."},{"key":"2021042623454678300_DEV184242C48","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1242\/dev.054395","article-title":"Restriction of hepatic competence by Fgf signaling","volume":"138","author":"Shin","year":"2011","journal-title":"Development"},{"key":"2021042623454678300_DEV184242C49","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1002\/hep.29752","article-title":"Wnt\/\u03b2-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating notch activity","volume":"67","author":"So","year":"2018","journal-title":"Hepatology"},{"key":"2021042623454678300_DEV184242C50","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.devcel.2009.05.012","article-title":"Sox17 regulates organ lineage segregation of ventral foregut progenitor cells","volume":"17","author":"Spence","year":"2009","journal-title":"Dev. Cell"},{"key":"2021042623454678300_DEV184242C51","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1158\/1541-7786.MCR-18-0158","article-title":"YAP tyrosine phosphorylation and nuclear localization in cholangiocarcinoma cells are regulated by LCK and independent of LATS activity","volume":"16","author":"Sugihara","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"2021042623454678300_DEV184242C52","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00535-019-01563-z","article-title":"YAP and the Hippo pathway in cholangiocarcinoma","volume":"54","author":"Sugihara","year":"2019","journal-title":"J. Gastroenterol."},{"key":"2021042623454678300_DEV184242C53","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.1038\/s41467-019-13149-7","article-title":"A morphogenetic EphB\/EphrinB code controls hepatopancreatic duct formation","volume":"10","author":"Thestrup","year":"2019","journal-title":"Nat. Commun."},{"key":"2021042623454678300_DEV184242C54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.semcdb.2017.02.003","article-title":"On the development of the hepatopancreatic ductal system","volume":"66","author":"Villasenor","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"2021042623454678300_DEV184242C55","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ydbio.2019.10.021","article-title":"Hhex regulates the specification and growth of the hepatopancreatic ductal system","volume":"458","author":"Villasenor","year":"2020","journal-title":"Dev. Biol."},{"key":"2021042623454678300_DEV184242C56","doi-asserted-by":"publisher","DOI":"10.3727\/105221619X15617324583639","article-title":"The hippo pathway and YAP signaling: emerging concepts in regulation, signaling, and experimental targeting strategies with implications for hepatobiliary malignancies","author":"Werneburg","year":"2019","journal-title":"Gene Expr."},{"key":"2021042623454678300_DEV184242C57","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.gep.2013.12.002","article-title":"A novel keratin18 promoter that drives reporter gene expression in the intrahepatic and extrahepatic biliary system allows isolation of cell-type specific transcripts from zebrafish liver","volume":"14","author":"Wilkins","year":"2014","journal-title":"Gene Expr. Patterns"},{"key":"2021042623454678300_DEV184242C58","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/labinvest.2017.29","article-title":"The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals","volume":"97","author":"Wu","year":"2017","journal-title":"Lab. Invest."},{"key":"2021042623454678300_DEV184242C59","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1002\/hep.28768","article-title":"Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ","volume":"64","author":"Yi","year":"2016","journal-title":"Hepatology"},{"key":"2021042623454678300_DEV184242C60","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"2021042623454678300_DEV184242C61","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.devcel.2010.06.015","article-title":"The Merlin\/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals","volume":"19","author":"Zhang","year":"2010","journal-title":"Dev. Cell"},{"key":"2021042623454678300_DEV184242C62","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ydbio.2014.08.025","article-title":"Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival","volume":"395","author":"Zhang","year":"2014","journal-title":"Dev. Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.184242","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.184242\/1967358\/dev184242.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.184242\/2064910\/dev_184242v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.184242\/2064910\/dev_184242v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T22:52:59Z","timestamp":1621378379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/doi\/10.1242\/dev.184242\/266937\/Core-Hippo-pathway-components-act-as-a-brake-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1242\/dev.184242","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"type":"electronic","value":"1477-9129"},{"type":"print","value":"0950-1991"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"article-number":"dev.184242"}}