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The excitatory neurons are generated from a unique progenitor zone, the rhombic lip, whereas the inhibitory neurons and astrocytes are generated from the ventricular zone. The growth phase of the cerebellum is driven by lineage-restricted progenitor populations derived from each zone. Research during the past decade has uncovered the importance of cell-to-cell communication between the lineages through largely unknown signaling mechanisms for regulating the scaling of cell numbers and cell plasticity during mouse development and following injury in the neonatal (P0-P14) cerebellum. This Review focuses on how the interplay between cell types is key to morphogenesis, production of robust neural circuits and replenishment of cells after injury, and ends with a discussion of the implications of the greater complexity of the human cerebellar progenitor zones for development and disease.<\/jats:p>","DOI":"10.1242\/dev.185587","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T09:10:17Z","timestamp":1664442617000},"source":"Crossref","is-referenced-by-count":36,"title":["Cerebellum lineage allocation, morphogenesis and repair: impact of interplay amongst cells"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-9605","authenticated-orcid":false,"given":"Alexandra L.","family":"Joyner","sequence":"first","affiliation":[{"name":"Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center 1 Developmental Biology Program , , New York, NY 10065 , USA"},{"name":"Weill Cornell Graduate School of Medical Sciences, Cornell University 2 Biochemistry Cell and Molecular Biology Program , , New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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