{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:02:29Z","timestamp":1753884149115,"version":"3.41.2"},"reference-count":138,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-20160o6644 UT"],"award-info":[{"award-number":["RGPIN-20160o6644 UT"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Princess Margaret Cancer Centre"},{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Long-term survival of an animal species depends on development being robust to environmental variations and climate changes. We used C. elegans to study how mechanisms that sense environmental changes trigger adaptive responses that ensure animals develop properly. In water, the nervous system induces an adaptive response that reinforces vulval development through an unknown backup signal for vulval induction. This response involves the heterotrimeric G-protein EGL-30\/\/G\u03b1q acting in motor neurons. It also requires body-wall muscle, which is excited by EGL-30-stimulated synaptic transmission, suggesting a behavioral function of neurons induces backup signal production from muscle. We now report that increased acetylcholine during liquid growth activates an EGL-30-Rho pathway, distinct from the synaptic transmission pathway, that increases Wnt production from motor neurons. We also provide evidence that this neuronal Wnt contributes to EGL-30-stimulated vulval development, with muscle producing a parallel developmental signal. As diverse sensory modalities stimulate motor neurons via acetylcholine, this mechanism enables broad sensory perception to enhance Wnt-dependent development. Thus, sensory perception improves animal fitness by activating distinct neuronal functions that trigger adaptive changes in both behavior and developmental processes.<\/jats:p>","DOI":"10.1242\/dev.186080","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T20:15:11Z","timestamp":1593116111000},"source":"Crossref","is-referenced-by-count":0,"title":["Sensory regulated Wnt production from neurons helps make organ development robust to environmental changes in <i>C. elegans<\/i>"],"prefix":"10.1242","volume":"147","author":[{"given":"Katarzyna","family":"Modzelewska","sequence":"first","affiliation":[{"name":"Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Brown","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Culotti","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-5089","authenticated-orcid":false,"given":"Nadeem","family":"Moghal","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA 1"},{"name":"Princess Margaret Cancer Centre\/University Health Network, Toronto, Ontario, M5G 1L7, Canada 3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"2024061301362314400_DEV186080C1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1126\/science.8342028","article-title":"The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter","volume":"261","author":"Alfonso","year":"1993","journal-title":"Science"},{"key":"2024061301362314400_DEV186080C2","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1523\/JNEUROSCI.14-04-02290.1994","article-title":"Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans","volume":"14","author":"Alfonso","year":"1994","journal-title":"J. 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