{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:23:15Z","timestamp":1787509395745,"version":"build-2736575974"},"reference-count":78,"publisher":"The Company of Biologists","issue":"11","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"National Centers for Translational Research in Reproduction and Infertility","award":["HD068157"],"award-info":[{"award-number":["HD068157"]}]},{"DOI":"10.13039\/100012756","name":"Lalor Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012756","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ruth L. Kirshstein","award":["HD089623"],"award-info":[{"award-number":["HD089623"]}]},{"name":"Roy & Diana Vagelos"},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["T32NR007100"],"award-info":[{"award-number":["T32NR007100"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although widely used, assisted reproductive technologies (ARTs) are associated with adverse perinatal outcomes. To elucidate their underlying causes, we have conducted a longitudinal analysis of placental development and fetal growth using a mouse model to investigate the effects of individual ART procedures: hormone stimulation, in vitro fertilization (IVF), embryo culture and embryo transfer. We demonstrate that transfer of blastocysts naturally conceived without hormone stimulation and developed in vivo prior to transfer can impair early placentation and fetal growth, but this effect normalizes by term. In contrast, embryos cultured in vitro before transfer do not exhibit this compensation but rather display placental overgrowth, reduced fetal weight, reduced placental DNA methylation and increased levels of sFLT1, an anti-angiogenic protein implicated in causing the maternal symptoms of preeclampsia in humans. Increases in sFLT1 observed in this study suggest that IVF procedures could increase the risk for preeclampsia. Moreover, our results indicate that embryo culture is the major factor contributing to most placental abnormalities and should therefore be targeted for optimization.<\/jats:p>","DOI":"10.1242\/dev.186551","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T14:36:46Z","timestamp":1590763006000},"source":"Crossref","is-referenced-by-count":43,"title":["Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse"],"prefix":"10.1242","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2202-1051","authenticated-orcid":false,"given":"Lisa A.","family":"Vrooman","sequence":"first","affiliation":[{"name":"Epigenetics Institute 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Perelman School of Medicine, University of Pennsylvania 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-724X","authenticated-orcid":false,"given":"Eric A.","family":"Rhon-Calderon","sequence":"additional","affiliation":[{"name":"Epigenetics Institute 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Perelman School of Medicine, University of Pennsylvania 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia Y.","family":"Chao","sequence":"additional","affiliation":[{"name":"Epigenetics Institute 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Perelman School of Medicine, University of Pennsylvania 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-2567","authenticated-orcid":false,"given":"Duy K.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Epigenetics Institute 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Perelman School of Medicine, University of Pennsylvania 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3327-4089","authenticated-orcid":false,"given":"Laren","family":"Narapareddy","sequence":"additional","affiliation":[{"name":"Epigenetics Institute 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Perelman School of Medicine, University of Pennsylvania 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Claire M. Fagin School of Nursing, University of Pennsylvania 2 Department of Family and Community Health , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha K.","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Epigenetics Institute 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Perelman School of Medicine, University of Pennsylvania 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-1288","authenticated-orcid":false,"given":"Mary E.","family":"Putt","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania 3 Department of Biostatistics, Epidemiology, and Informatics , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-6825","authenticated-orcid":false,"given":"Richard M.","family":"Schultz","sequence":"additional","affiliation":[{"name":"School of Arts and Sciences, University of Pennsylvania 4 Department of Biology , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-5222","authenticated-orcid":false,"given":"Marisa S.","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Epigenetics Institute 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"},{"name":"Perelman School of Medicine, University of Pennsylvania 1 , Department of Cell and Developmental Biology , , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"2024061301311627000_DEV186551C1","unstructured":"Adamson, D. G., Zegers-Hochschild, F., Ishihara, O., Sullivan, E. A., Mansour, R., Nygren, K. G., Banker, M., Dyer, S. and De Mouzon, J. (2012). ICMART World Report: Preliminary 2008 Data. London, UK."},{"key":"2024061301311627000_DEV186551C2","volume-title":"50 \u2013 Nonradioactive In Situ Hybridization: Optimization for Tissue Sections from Pregnant Uteri and Placenta during the First Half of Pregnancy","author":"Bany","year":"2014"},{"key":"2024061301311627000_DEV186551C3","doi-asserted-by":"publisher","first-page":"1507674","DOI":"10.1155\/2018\/1507674","article-title":"Placenta accreta spectrum: a review of pathology, molecular biology, and biomarkers","volume":"2018","author":"Bartels","year":"2018","journal-title":"Dis. Markers"},{"key":"2024061301311627000_DEV186551C4","first-page":"92","article-title":"Mouse colony setup","volume-title":"Manipulating the Mouse Embryo: A Laboratory Manual","author":"Behringer","year":"2014"},{"key":"2024061301311627000_DEV186551C5","first-page":"109","article-title":"Recovery and in vitro culture of preimplantation embryos","volume-title":"Manipulating the Mouse Embryo: A Laboratory Manual","author":"Behringer","year":"2014"},{"key":"2024061301311627000_DEV186551C6","first-page":"604","article-title":"Assisted Reproduction","volume-title":"Manipulating the Mouse Embryo: A Laboratory Manual","author":"Behringer","year":"2014"},{"key":"2024061301311627000_DEV186551C7","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1111\/j.1582-4934.2009.00820.x","article-title":"Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model","volume":"14","author":"Bergmann","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"2024061301311627000_DEV186551C8","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.1210\/en.2011-1921","article-title":"Impaired placental nutrient transport in mice generated by in vitro fertilization","volume":"153","author":"Bloise","year":"2012","journal-title":"Endocrinology"},{"key":"2024061301311627000_DEV186551C9","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1093\/humupd\/dmu032","article-title":"Comparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding","volume":"20","author":"Bloise","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"2024061301311627000_DEV186551C10","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.placenta.2005.09.009","article-title":"Tracing the glycogen cells with protocadherin 12 during mouse placenta development","volume":"27","author":"Bouillot","year":"2006","journal-title":"Placenta"},{"key":"2024061301311627000_DEV186551C11","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1093\/humrep\/der117","article-title":"Assisted conception and placental perfusion assessed by uterine artery Doppler at 11-13 weeks\u2019 gestation","volume":"26","author":"Carbone","year":"2011","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C12","volume-title":"2015 Assisted Reproductive Technology National Summary Report","author":"Centers for Disease Control and Prevention","year":"2017"},{"key":"2024061301311627000_DEV186551C13","doi-asserted-by":"publisher","first-page":"10596","DOI":"10.1038\/srep10596","article-title":"Assisted reproduction causes placental maldevelopment and dysfunction linked to reduced fetal weight in mice","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"2024061301311627000_DEV186551C14","doi-asserted-by":"publisher","first-page":"4618","DOI":"10.1073\/pnas.1422088112","article-title":"Characterization of global loss of imprinting in fetal overgrowth syndrome induced by assisted reproduction","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061301311627000_DEV186551C15","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.rbmo.2018.12.023","article-title":"Placental volume and other first-trimester outcomes: are there differences between fresh embryo transfer, frozen-thawed embryo transfer and natural conception?","volume":"38","author":"Choux","year":"2019","journal-title":"Reprod. Biomed. Online"},{"key":"2024061301311627000_DEV186551C16","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1002\/dvdy.20981","article-title":"Origin and characteristics of glycogen cells in the developing murine placenta","volume":"235","author":"Coan","year":"2006","journal-title":"Dev. Dyn."},{"key":"2024061301311627000_DEV186551C17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jsbmb.2009.04.005","article-title":"Assisted reproduction technologies impair placental steroid metabolism","volume":"116","author":"Collier","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"2024061301311627000_DEV186551C18","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/j.fertnstert.2010.12.010","article-title":"The effect of infertility and assisted reproduction on first-trimester placental and fetal development","volume":"95","author":"Conway","year":"2011","journal-title":"Fertil. Steril."},{"key":"2024061301311627000_DEV186551C19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.placenta.2019.05.010","article-title":"Association between fertility treatments and early placentation markers","volume":"82","author":"C\u00f4t\u00e9","year":"2019","journal-title":"Placenta"},{"key":"2024061301311627000_DEV186551C20","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1093\/humrep\/14.4.1107","article-title":"Do placentae of term singleton pregnancies obtained by assisted reproductive technologies differ from those of spontaneously conceived pregnancies?","volume":"14","author":"Daniel","year":"1999","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C21","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1073\/pnas.1201990109","article-title":"Primary epimutations introduced during intracytoplasmic sperm injection (ICSI) are corrected by germline-specific epigenetic reprogramming","volume":"109","author":"de Waal","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061301311627000_DEV186551C22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.113.114785","article-title":"In vitro culture increases the frequency of stochastic epigenetic errors at imprinted genes in placental tissues from mouse concepti produced through assisted reproductive technologies","volume":"90","author":"de Waal","year":"2014","journal-title":"Biol. Reprod."},{"key":"2024061301311627000_DEV186551C23","doi-asserted-by":"publisher","first-page":"6975","DOI":"10.1093\/hmg\/ddv400","article-title":"The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model","volume":"24","author":"de Waal","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2024061301311627000_DEV186551C24","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jogoh.2019.03.008","article-title":"Influence of assisted reproductive technologies on maternal and neonatal outcomes in early preterm deliveries","volume":"48","author":"Di Tommaso","year":"2019","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"2024061301311627000_DEV186551C25","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1095\/biolreprod62.6.1526","article-title":"Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo","volume":"62","author":"Doherty","year":"2000","journal-title":"Biol. Reprod."},{"key":"2024061301311627000_DEV186551C26","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/humrep\/dep456","article-title":"Effect of in vitro culture of human embryos on birthweight of newborns","volume":"25","author":"Dumoulin","year":"2010","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C27","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1093\/humrep\/dew082","article-title":"International committee for monitoring assisted reproductive technologies world report: assisted reproductive technology 2008, 2009 and 2010","volume":"31","author":"Dyer","year":"2016","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C28","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/humrep\/deu271","article-title":"The influence of IVF\/ICSI treatment on human embryonic growth trajectories","volume":"29","author":"Eindhoven","year":"2014","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C29","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1111\/j.1471-0528.2011.02976.x","article-title":"Placenta accreta is associated with IVF pregnancies: a retrospective chart review","volume":"118","author":"Esh-Broder","year":"2011","journal-title":"BJOG"},{"key":"2024061301311627000_DEV186551C30","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/1471-213X-7-116","article-title":"Assisted Reproductive Technology affects developmental kinetics, H19 Imprinting Control Region methylation and H19 gene expression in individual mouse embryos","volume":"7","author":"Fauque","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"2024061301311627000_DEV186551C31","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0301-2115(03)00179-9","article-title":"Placental insufficiency and its consequences","volume":"110","author":"Gagnon","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"2024061301311627000_DEV186551C32","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1093\/humrep\/der428","article-title":"Placental weight in singleton pregnancies with and without assisted reproductive technology: a population study of 536,567 pregnancies","volume":"27","author":"Haavaldsen","year":"2012","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C33","doi-asserted-by":"publisher","first-page":"e20174069","DOI":"10.1542\/peds.2017-4069","article-title":"Health of infants after ART-treated, subfertile, and fertile deliveries","volume":"142","author":"Hwang","year":"2018","journal-title":"Pediatrics"},{"key":"2024061301311627000_DEV186551C34","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1042\/BST20130002","article-title":"Epigenetic regulation of placental endocrine lineages and complications of pregnancy","volume":"41","author":"John","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"2024061301311627000_DEV186551C35","doi-asserted-by":"publisher","first-page":"306","DOI":"10.2350\/11-11-1115-OA.1","article-title":"Is assisted reproduction associated with abnormal placentation?","volume":"15","author":"Joy","year":"2012","journal-title":"Pediatr. Dev. Pathol."},{"key":"2024061301311627000_DEV186551C36","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3109\/14647273.2015.1083620","article-title":"Biochemical markers of placental dysfunction in assisted conception","volume":"18","author":"Joy","year":"2015","journal-title":"Hum. Fertil. (Camb)."},{"key":"2024061301311627000_DEV186551C37","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.fertnstert.2015.01.021","article-title":"Cryopreserved embryo transfer is an independent risk factor for placenta accreta","volume":"103","author":"Kaser","year":"2015","journal-title":"Fertil. Steril."},{"key":"2024061301311627000_DEV186551C38","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1038\/ejhg.2009.68","article-title":"DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm","volume":"17","author":"Kobayashi","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"2024061301311627000_DEV186551C39","doi-asserted-by":"publisher","first-page":"212.e1","DOI":"10.1016\/j.ajog.2015.03.032","article-title":"Angiogenic markers in pregnancies conceived through in vitro fertilization","volume":"213","author":"Lee","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2024061301311627000_DEV186551C40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10815-016-0850-x","article-title":"Increased risk of large-for-gestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles","volume":"34","author":"Luke","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"2024061301311627000_DEV186551C41","doi-asserted-by":"publisher","first-page":"P350.E1","DOI":"10.1016\/j.ajog.2019.10.003","article-title":"In vitro fertilization and risk for hypertensive disorders of pregnancy: associations with treatment parameters","volume":"222","author":"Luke","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2024061301311627000_DEV186551C42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.113.110411","article-title":"Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth","volume":"90","author":"Mainigi","year":"2013","journal-title":"Biol. Reprod."},{"key":"2024061301311627000_DEV186551C43","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2024061301311627000_DEV186551C44","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1242\/dev.01241","article-title":"Selective loss of imprinting in the placenta following preimplantation development in culture","volume":"131","author":"Mann","year":"2004","journal-title":"Development"},{"key":"2024061301311627000_DEV186551C45","doi-asserted-by":"publisher","first-page":"e80398","DOI":"10.1371\/journal.pone.0080398","article-title":"Perinatal outcomes by mode of assisted conception and sub-fertility in an Australian data linkage cohort","volume":"9","author":"Marino","year":"2014","journal-title":"PLoS ONE"},{"key":"2024061301311627000_DEV186551C46","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2024061301311627000_DEV186551C47","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1530\/REP-19-0293","article-title":"Blastocyst transfer in mice alters the placental transcriptome and growth","volume":"159","author":"Menelaou","year":"2020","journal-title":"Reproduction"},{"key":"2024061301311627000_DEV186551C48","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1477-7827-6-34","article-title":"In vivo quantification of embryonic and placental growth during gestation in mice using micro-ultrasound","volume":"6","author":"Mu","year":"2008","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2024061301311627000_DEV186551C49","volume-title":"Manipulating the Mouse Embryo: A Laboratory Manual","author":"Nagy","year":"2003","edition":"3rd edn."},{"key":"2024061301311627000_DEV186551C50","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1093\/humrep\/des145","article-title":"Further evidence that culture media affect perinatal outcome: findings after transfer of fresh and cryopreserved embryos","volume":"27","author":"Nelissen","year":"2012","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C51","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1093\/humrep\/des459","article-title":"Placentas from pregnancies conceived by IVF\/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions","volume":"28","author":"Nelissen","year":"2013","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C52","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.placenta.2015.05.013","article-title":"Genetic ablation of placental sinusoidal trophoblast giant cells causes fetal growth restriction and embryonic lethality","volume":"36","author":"Outhwaite","year":"2015","journal-title":"Placenta"},{"key":"2024061301311627000_DEV186551C53","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/molehr\/gaw077","article-title":"Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis","volume":"23","author":"Palmer","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"2024061301311627000_DEV186551C54","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/humupd\/dms018","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF\/ICSI: a systematic review and meta-analysis","volume":"18","author":"Pandey","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"2024061301311627000_DEV186551C55","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1172\/JCI99026","article-title":"Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice","volume":"128","author":"Parchem","year":"2018","journal-title":"J. Clin. Invest."},{"key":"2024061301311627000_DEV186551C56","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1093\/molehr\/gau049","article-title":"Dynamic regulation of DNA methyltransferases in human oocytes and preimplantation embryos after assisted reproductive technologies","volume":"20","author":"Petrussa","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"2024061301311627000_DEV186551C57","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1093\/humrep\/dez036","article-title":"Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse model","volume":"34","author":"Rahimi","year":"2019","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C58","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.placenta.2019.02.013","article-title":"The effects of Assisted Reproductive Technologies on genomic imprinting in the placenta","volume":"84","author":"Rhon-Calderon","year":"2019","journal-title":"Placenta"},{"key":"2024061301311627000_DEV186551C59","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1177\/1933719116641765","article-title":"Are there differences in placental volume and uterine artery Doppler in pregnancies resulting from the transfer of fresh versus frozen-thawed embryos through in vitro fertilization","volume":"23","author":"Rizzo","year":"2016","journal-title":"Reprod. Sci."},{"key":"2024061301311627000_DEV186551C60","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1093\/humrep\/dew214","article-title":"Assessment of \u2018one-step\u2019 versus \u2018sequential\u2019 embryo culture conditions through embryonic genome methylation and hydroxymethylation changes","volume":"31","author":"Salvaing","year":"2016","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C61","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1093\/humrep\/der394","article-title":"First trimester serum angiogenic\/anti-angiogenic status in twin pregnancies: relationship with assisted reproduction technology","volume":"27","author":"Sanchez","year":"2012","journal-title":"Hum. Reprod."},{"key":"2024061301311627000_DEV186551C62","doi-asserted-by":"publisher","first-page":"dev160622","DOI":"10.1242\/dev.160622","article-title":"Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring","volume":"145","author":"SanMiguel","year":"2018","journal-title":"Development"},{"key":"2024061301311627000_DEV186551C63","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s10995-007-0202-7","article-title":"A population-based study of maternal and perinatal outcomes associated with assisted reproductive technology in Massachusetts","volume":"11","author":"Schieve","year":"2007","journal-title":"Matern. Child Health J."},{"key":"2024061301311627000_DEV186551C64","volume-title":"The Guide to Investigation of Mouse Pregnancy","author":"Simmons","year":"2014"},{"key":"2024061301311627000_DEV186551C65","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s10815-018-1238-x","article-title":"Birth outcomes of singleton vaginal deliveries to ART-treated, subfertile, and fertile primiparous women","volume":"35","author":"Stern","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"2024061301311627000_DEV186551C66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.114.124248","article-title":"Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas","volume":"91","author":"Sui","year":"2014","journal-title":"Biol. Reprod."},{"key":"2024061301311627000_DEV186551C67","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s10815-018-1176-7","article-title":"Mode of conception does not affect fetal or placental growth parameters or ratios in early gestation or at delivery","volume":"35","author":"Sundheimer","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"2024061301311627000_DEV186551C68","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/molehr\/gaw028","article-title":"Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues","volume":"22","author":"Tan","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"2024061301311627000_DEV186551C69","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/jch.12945","article-title":"Risk of hypertensive disorders in pregnancy following assisted reproductive technology: overview and meta-analysis","volume":"19","author":"Thomopoulos","year":"2017","journal-title":"J. Clin. Hypertens."},{"key":"2024061301311627000_DEV186551C70","doi-asserted-by":"publisher","first-page":"R117","DOI":"10.1530\/REP-12-0511","article-title":"Imprinted genes in mouse placental development and the regulation of fetal energy stores","volume":"145","author":"Tunster","year":"2013","journal-title":"Reproduction"},{"key":"2024061301311627000_DEV186551C71","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fcell.2018.00123","article-title":"Peg3 deficiency results in sexually dimorphic losses and gains in the normal repertoire of placental hormones","volume":"6","author":"Tunster","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"2024061301311627000_DEV186551C72","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/1471-0528.15227","article-title":"Are singleton pregnancies after assisted reproduction technology (ART) associated with a higher risk of placental anomalies compared with non-ART singleton pregnancies? A systematic review and meta-analysis","volume":"126","author":"Vermey","year":"2018","journal-title":"BJOG"},{"key":"2024061301311627000_DEV186551C73","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1161\/HYPERTENSIONAHA.118.12043","article-title":"Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a Corpus Luteum","volume":"73","author":"von Versen-H\u00f6ynck","year":"2019","journal-title":"Hypertension"},{"key":"2024061301311627000_DEV186551C74","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1093\/hmg\/ddw293","article-title":"Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterning","volume":"25","author":"Whidden","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"2024061301311627000_DEV186551C75","doi-asserted-by":"publisher","first-page":"17311","DOI":"10.1038\/srep17311","article-title":"High frequency of imprinted methylation errors in human preimplantation embryos","volume":"5","author":"White","year":"2015","journal-title":"Sci. Rep."},{"key":"2024061301311627000_DEV186551C76","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1016\/j.fertnstert.2010.01.014","article-title":"In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: a prospective follow-up study","volume":"94","author":"Wisborg","year":"2010","journal-title":"Fertil. Steril."},{"key":"2024061301311627000_DEV186551C77","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3389\/fendo.2018.00570","article-title":"Regulation of placental development and its impact on fetal growth-new insights from mouse models","volume":"9","author":"Woods","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"2024061301311627000_DEV186551C78","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1095\/biolreprod.110.090589","article-title":"Ultrastructural study on human placentae from women subjected to assisted reproductive technology treatments","volume":"85","author":"Zhang","year":"2011","journal-title":"Biol. Reprod."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.186551","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.186551\/3481588\/dev186551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.186551\/3481588\/dev186551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T21:31:36Z","timestamp":1718227896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/147\/11\/dev186551\/225304\/Assisted-reproductive-technologies-induce"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":78,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.186551","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,29]]},"article-number":"dev186551"}}