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The mechanisms regulating these RGC fate decisions are still incompletely understood. Here we describe a novel and evolutionarily conserved role of the canonical BMP transcription factors SMAD1\/5 in controlling neurogenesis and growth during corticogenesis. Reducing the expression of both SMAD1 and SMAD5 in neural progenitors at early mouse cortical development caused microcephaly and an increased production of early-born cortical neurons at the expense of late-born ones, which correlated with the premature differentiation and depletion of the pool of cortical progenitors. Gain- and loss-of-function experiments performed during early cortical neurogenesis in the chick revealed that SMAD1\/5 activity supports self-amplifying RGC divisions and restrain the neurogenic ones. Furthermore, we demonstrate that SMAD1\/5 stimulate RGC self-amplification through the positive post-transcriptional regulation of the Hippo signaling effector YAP. We anticipate this SMAD1\/5-YAP signaling module to be fundamental in controlling growth and evolution of the amniote cerebral cortex.<\/jats:p>","DOI":"10.1242\/dev.187005","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T17:45:11Z","timestamp":1592243111000},"source":"Crossref","is-referenced-by-count":22,"title":["A SMAD1\/5-YAP signaling module drives radial glia self-amplification and growth of the developing cerebral cortex"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8804-2528","authenticated-orcid":false,"given":"Sonia","family":"Najas","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, C\/ Baldiri Reixac 10-15, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Pijuan","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, C\/ Baldiri Reixac 10-15, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Esteve-Codina","sequence":"additional","affiliation":[{"name":"CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Usieto","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, C\/ Baldiri Reixac 10-15, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, C\/ Baldiri Reixac 10-15, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zwijsen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven, Leuven 3000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Arbon\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, C\/ Baldiri Reixac 10-15, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, C\/ Baldiri Reixac 10-15, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenvael","family":"Le Dr\u00e9au","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Instituto de Biolog\u00eda Molecular de Barcelona, CSIC, Parc Cient\u00edfic de Barcelona, C\/ Baldiri Reixac 10-15, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042623443712500_DEV187005C1","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.cell.2009.09.035","article-title":"Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways","volume":"139","author":"Alarc\u00f3n","year":"2009","journal-title":"Cell"},{"key":"2021042623443712500_DEV187005C2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuron.2004.12.036","article-title":"Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo","volume":"45","author":"Arlotta","year":"2005","journal-title":"Neuron"},{"key":"2021042623443712500_DEV187005C3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/(SICI)1098-1136(199606)17:2&lt;169::AID-GLIA8&gt;3.0.CO;2-Y","article-title":"Expression of the APC tumor suppressor protein in oligodendroglia","volume":"17","author":"Bhat","year":"1996","journal-title":"Glia"},{"key":"2021042623443712500_DEV187005C4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.neuron.2007.12.028","article-title":"Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex","volume":"57","author":"Britanova","year":"2008","journal-title":"Neuron"},{"key":"2021042623443712500_DEV187005C5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0896-6273(95)90065-9","article-title":"T-Brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex","volume":"15","author":"Bulfone","year":"1995","journal-title":"Neuron"},{"key":"2021042623443712500_DEV187005C6","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/ng.2765","article-title":"Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development","volume":"45","author":"Cappello","year":"2013","journal-title":"Nat. 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