{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:37:04Z","timestamp":1765546624583,"version":"3.41.2"},"reference-count":129,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC13074"],"award-info":[{"award-number":["DC13074"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006580","name":"Office of the Chief Scientist, Ministry of Health","doi-asserted-by":"crossref","award":["3-0000-33793"],"award-info":[{"award-number":["3-0000-33793"]}],"id":[{"id":"10.13039\/501100006580","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Fragile X mental retardation protein (FMRP) is an RNA-binding protein abundant in the nervous system. Functional loss of FMRP leads to sensory dysfunction and severe intellectual disabilities. In the auditory system, FMRP deficiency alters neuronal function and synaptic connectivity and results in perturbed processing of sound information. Nevertheless, roles of FMRP in embryonic development of the auditory hindbrain have not been identified. Here, we developed high-specificity approaches to genetically track and manipulate throughout development the Atho1+ neuronal cell type, which is highly conserved in vertebrates, in the cochlear nucleus of chicken embryos. We identified distinct FMRP-containing granules in the growing axons of Atho1+ neurons and post-migrating NM cells. FMRP downregulation via Crispr\/Cas9 and shRNA techniques resulted in perturbed axonal pathfinding, delay in midline crossing, excess branching of neurites, and axonal targeting errors during the period of circuit development. Together, these results provide the first in vivo identification of FMRP localization and actions in developing axons of auditory neurons, and demonstrate the importance of investigating early embryonic alterations toward understanding the pathogenesis of neurodevelopmental disorders.<\/jats:p>","DOI":"10.1242\/dev.188797","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T18:35:23Z","timestamp":1596479723000},"source":"Crossref","is-referenced-by-count":12,"title":["Temporal-specific roles of Fragile X mental retardation protein in the development of hindbrain auditory circuit"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-7089","authenticated-orcid":false,"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, FL 32306, USA"},{"name":"Division of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayelet","family":"Kohl","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-0114","authenticated-orcid":false,"given":"Xiaoyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, FL 32306, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego A. R.","family":"Zorio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, FL 32306, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avihu","family":"Klar","sequence":"additional","affiliation":[{"name":"Department of Medical Neurobiology IMRIC, Hebrew University Medical School, Jerusalem 91120, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-061X","authenticated-orcid":false,"given":"Dalit","family":"Sela-Donenfeld","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-7063","authenticated-orcid":false,"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, FL 32306, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042700580346400_DEV188797C1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/ng0693-147","article-title":"Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain","volume":"4","author":"Abitbol","year":"1993","journal-title":"Nat. Genet."},{"key":"2021042700580346400_DEV188797C2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1749-8104-7-29","article-title":"Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system","volume":"7","author":"Allen-Sharpley","year":"2012","journal-title":"Neural Dev."},{"key":"2021042700580346400_DEV188797C3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mcn.2006.02.001","article-title":"Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses","volume":"32","author":"Antar","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"2021042700580346400_DEV188797C4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1749-8104-4-21","article-title":"Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1","volume":"4","author":"Avraham","year":"2009","journal-title":"Neural Dev."},{"key":"2021042700580346400_DEV188797C5","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nrn1667","article-title":"From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome","volume":"6","author":"Bagni","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042700580346400_DEV188797C6","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.neuron.2019.02.041","article-title":"A synaptic perspective of fragile X syndrome and autism spectrum disorders","volume":"101","author":"Bagni","year":"2019","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C7","doi-asserted-by":"publisher","first-page":"4999","DOI":"10.1242\/dev.00713","article-title":"Axon fasciculation and differences in midline kinetics between pioneer and follower axons within commissural fascicles","volume":"130","author":"Bak","year":"2003","journal-title":"Development"},{"key":"2021042700580346400_DEV188797C8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/ajmg.b.10035","article-title":"White matter tract alterations in fragile X syndrome: Preliminary evidence from diffusion tensor imaging","volume":"118B","author":"Barnea-Goraly","year":"2003","journal-title":"Am. J. Med. Genet."},{"key":"2021042700580346400_DEV188797C9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.neuron.2008.10.004","article-title":"Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function","volume":"60","author":"Bassell","year":"2008","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C10","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"Bear","year":"2004","journal-title":"Trends Neurosci."},{"key":"2021042700580346400_DEV188797C11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0896-6273(01)00305-1","article-title":"Proprioceptor pathway development is dependent on Math1","volume":"30","author":"Bermingham","year":"2001","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C12","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.1113\/JP272205","article-title":"Functional and structural properties of ion channels at the nerve terminal depends on compact myelin: ion channels at the CNS nerve terminal","volume":"594","author":"Berret","year":"2016","journal-title":"J. Physiol."},{"key":"2021042700580346400_DEV188797C13","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fnmol.2016.00060","article-title":"The presynaptic microtubule cytoskeleton in physiological and pathological conditions: lessons from Drosophila fragile X syndrome and hereditary spastic paraplegias","volume":"9","author":"Bodaleo","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"2021042700580346400_DEV188797C14","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nn.2563","article-title":"Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack","volume":"13","author":"Brown","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2021042700580346400_DEV188797C15","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1073\/pnas.1618606114","article-title":"DSCAM promotes axon fasciculation and growth in the developing optic pathway","volume":"114","author":"Bruce","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042700580346400_DEV188797C16","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1523\/JNEUROSCI.1076-08.2008","article-title":"Circuit and plasticity defects in the developing somatosensory cortex of Fmr1 knock-out mice","volume":"28","author":"Bureau","year":"2008","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2741\/s455","article-title":"Cortical neurogenesis in fragile X syndrome","volume":"8","author":"Castr\u00e9n","year":"2016","journal-title":"Front. Biosci."},{"key":"2021042700580346400_DEV188797C18","doi-asserted-by":"publisher","first-page":"a001917","DOI":"10.1101\/cshperspect.a001917","article-title":"Wiring the brain: the biology of neuronal guidance","volume":"2","author":"Ch\u00e9dotal","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"2021042700580346400_DEV188797C19","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1523\/JNEUROSCI.3937-08.2009","article-title":"The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits","volume":"29","author":"Christie","year":"2009","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C20","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/cne.24321","article-title":"Fragile X granules are a family of axonal ribonucleoprotein particles with circuit-dependent protein composition and mRNA cargos","volume":"526","author":"Chyung","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13064-019-0133-1","article-title":"Commissural axon guidance in the developing spinal cord: from Cajal to the present day","volume":"14","author":"Comer","year":"2019","journal-title":"Neural Dev"},{"key":"2021042700580346400_DEV188797C22","doi-asserted-by":"publisher","first-page":"5401","DOI":"10.1073\/pnas.94.10.5401","article-title":"Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits","volume":"94","author":"Comery","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042700580346400_DEV188797C23","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"2021042700580346400_DEV188797C24","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1006\/dbio.2000.9779","article-title":"Embryonic origins of auditory brain-stem nuclei in the chick hindbrain","volume":"224","author":"Cramer","year":"2000","journal-title":"Dev. Biol."},{"key":"2021042700580346400_DEV188797C25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ydbio.2004.01.002","article-title":"EphA4 signaling promotes axon segregation in the developing auditory system","volume":"269","author":"Cramer","year":"2004","journal-title":"Dev. Biol."},{"key":"2021042700580346400_DEV188797C26","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.tig.2017.07.008","article-title":"Multifarious functions of the fragile X mental retardation protein","volume":"33","author":"Davis","year":"2017","journal-title":"Trends Genet."},{"key":"2021042700580346400_DEV188797C27","doi-asserted-by":"publisher","first-page":"8332","DOI":"10.1128\/MCB.22.23.8332-8341.2002","article-title":"Transport of fragile X mental retardation protein via granules in neurites of PC12 cells","volume":"22","author":"De Diego Otero","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2021042700580346400_DEV188797C28","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.neuron.2012.12.018","article-title":"FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels","volume":"77","author":"Deng","year":"2013","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C29","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1089\/scd.2014.0030","article-title":"iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth","volume":"23","author":"Doers","year":"2014","journal-title":"Stem Cells Dev."},{"key":"2021042700580346400_DEV188797C30","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1242\/dev.117127","article-title":"Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory","volume":"142","author":"Doll","year":"2015","journal-title":"Development"},{"key":"2021042700580346400_DEV188797C31","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/glia.23731","article-title":"The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth","volume":"68","author":"Doll","year":"2020","journal-title":"Glia"},{"key":"2021042700580346400_DEV188797C32","doi-asserted-by":"publisher","first-page":"4797","DOI":"10.1523\/JNEUROSCI.0839-18.2019","article-title":"Modulators of Kv3 potassium channels rescue the auditory function of fragile X mice","volume":"39","author":"El-Hassar","year":"2019","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C33","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.neuron.2006.03.014","article-title":"Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps","volume":"50","author":"Farago","year":"2006","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C34","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.1093\/brain\/awr249","article-title":"Resolution of spatial and temporal visual attention in infants with fragile X syndrome","volume":"134","author":"Farzin","year":"2011","journal-title":"Brain"},{"key":"2021042700580346400_DEV188797C35","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1038\/ncomms4628","article-title":"Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density","volume":"5","author":"Ferron","year":"2014","journal-title":"Nat. Commun."},{"key":"2021042700580346400_DEV188797C36","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1006\/dbio.1996.0027","article-title":"Low-affinity NGF-receptor and E-N-CAM expression define two types of olfactory nerve ensheathing cells that share a common lineage","volume":"173","author":"Franceschini","year":"1996","journal-title":"Dev. Biol."},{"key":"2021042700580346400_DEV188797C37","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1242\/dev.033480","article-title":"Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1","volume":"136","author":"Fujiyama","year":"2009","journal-title":"Development"},{"key":"2021042700580346400_DEV188797C38","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/ajmg.a.30709","article-title":"Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome","volume":"135A","author":"Galvez","year":"2005","journal-title":"Am. J. Med. Genet. A"},{"key":"2021042700580346400_DEV188797C39","doi-asserted-by":"publisher","first-page":"7403","DOI":"10.1523\/JNEUROSCI.2310-16.2017","article-title":"Enhanced excitatory connectivity and disturbed sound processing in the auditory brainstem of fragile X mice","volume":"37","author":"Garcia-Pino","year":"2017","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C40","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1523\/JNEUROSCI.4390-03.2004","article-title":"An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells","volume":"24","author":"Goldberg","year":"2004","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fnana.2013.00007","article-title":"Transcription factors define the neuroanatomical organization of the medullary reticular formation","volume":"7","author":"Gray","year":"2013","journal-title":"Front. Neuroanat."},{"key":"2021042700580346400_DEV188797C42","doi-asserted-by":"publisher","first-page":"e148","DOI":"10.1093\/nar\/gku750","article-title":"A \u2018tool box\u2019 for deciphering neuronal circuits in the developing chick spinal cord","volume":"42","author":"Hadas","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2021042700580346400_DEV188797C43","doi-asserted-by":"publisher","first-page":"17065","DOI":"10.1038\/nrdp.2017.65","article-title":"Fragile X syndrome","volume":"3","author":"Hagerman","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"2021042700580346400_DEV188797C44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.stemcr.2014.10.015","article-title":"Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells","volume":"4","author":"Halevy","year":"2015","journal-title":"Stem Cell Rep."},{"key":"2021042700580346400_DEV188797C45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s11689-009-9007-x","article-title":"The neural basis of auditory temporal discrimination in girls with fragile X syndrome","volume":"1","author":"Hall","year":"2009","journal-title":"J. Neurodev. Disord."},{"key":"2021042700580346400_DEV188797C46","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1242\/dev.127.6.1185","article-title":"Autoregulation and multiple enhancers control Math1 expression in the developing nervous system","volume":"127","author":"Helms","year":"2000","journal-title":"Development"},{"key":"2021042700580346400_DEV188797C47","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/cne.21031","article-title":"Formation of the avian nucleus magnocellularis from the auditory anlage","volume":"498","author":"Hendricks","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C48","doi-asserted-by":"publisher","first-page":"5727","DOI":"10.1523\/JNEUROSCI.5229-05.2006","article-title":"Functional and selective RNA interference in developing axons and growth cones","volume":"26","author":"Hengst","year":"2006","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C49","doi-asserted-by":"publisher","first-page":"20150496","DOI":"10.1098\/rstb.2015.0496","article-title":"CRISPR-Cas: biology, mechanisms and relevance","volume":"371","author":"Hille","year":"2016","journal-title":"Phil. Trans. R. Soc. B"},{"key":"2021042700580346400_DEV188797C50","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/ng0193-36","article-title":"Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome","volume":"3","author":"Hinds","year":"1993","journal-title":"Nat. Genet."},{"key":"2021042700580346400_DEV188797C51","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1006\/dbio.1998.9093","article-title":"In vitro studies of growth cone behavior support a role for fasciculation mediated by cell adhesion molecules in sensory axon guidance during development","volume":"204","author":"Honig","year":"1998","journal-title":"Dev. Biol."},{"key":"2021042700580346400_DEV188797C52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/hipo.10004","article-title":"Altered mossy fiber distributions in adultFmr1 (FVB) knockout mice","volume":"12","author":"Ivanco","year":"2002","journal-title":"Hippocampus"},{"key":"2021042700580346400_DEV188797C53","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/dneu.22360","article-title":"Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones: local translation of Dscam","volume":"76","author":"Jain","year":"2016","journal-title":"Dev. Neurobiol."},{"key":"2021042700580346400_DEV188797C54","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/glia.23284","article-title":"Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome","volume":"66","author":"Jawaid","year":"2018","journal-title":"Glia"},{"key":"2021042700580346400_DEV188797C55","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13041-019-0472-1","article-title":"Drosophila Netrin-B controls mushroom body axon extension and regulates courtship-associated learning and memory of a Drosophila fragile X syndrome model","volume":"12","author":"Kang","year":"2019","journal-title":"Mol. Brain"},{"key":"2021042700580346400_DEV188797C56","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1242\/dev.089136","article-title":"A novel role for Pax6 in the segmental organization of the hindbrain","volume":"140","author":"Kayam","year":"2013","journal-title":"Development"},{"key":"2021042700580346400_DEV188797C57","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/316728a0","article-title":"Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies","volume":"316","author":"Keilhauer","year":"1985","journal-title":"Nature"},{"key":"2021042700580346400_DEV188797C58","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.neuroscience.2011.06.074","article-title":"Fragile X protein expression is linked to visual functions in healthy male volunteers","volume":"192","author":"K\u00e9ri","year":"2011","journal-title":"Neuroscience"},{"key":"2021042700580346400_DEV188797C59","doi-asserted-by":"publisher","first-page":"15686","DOI":"10.1523\/JNEUROSCI.3246-12.2013","article-title":"Impaired critical period plasticity in primary auditory cortex of fragile X model mice","volume":"33","author":"Kim","year":"2013","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C60","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1212\/01.WNL.0000142987.44035.3B","article-title":"Integrative cortical dysfunction and pervasive motion perception deficit in fragile X syndrome","volume":"63","author":"Kogan","year":"2004","journal-title":"Neurology"},{"key":"2021042700580346400_DEV188797C61","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1523\/JNEUROSCI.4231-11.2012","article-title":"Axonal patterns and targets of dA1 interneurons in the chick hindbrain","volume":"32","author":"Kohl","year":"2012","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C62","doi-asserted-by":"publisher","first-page":"e50136","DOI":"10.3791\/50136","article-title":"Electroporation of the hindbrain to trace axonal trajectories and synaptic targets in the chick embryo","volume":"75","author":"Kohl","year":"2013","journal-title":"J. Vis. Exp."},{"key":"2021042700580346400_DEV188797C63","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1523\/JNEUROSCI.2699-14.2015","article-title":"Control of Axon Guidance and Neurotransmitter Phenotype of dB1 Hindbrain Interneurons by Lim-HD Code","volume":"35","author":"Kohl","year":"2015","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C64","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1002\/cne.22786","article-title":"Astrocyte-secreted factors modulate the developmental distribution of inhibitory synapses in nucleus laminaris of the avian auditory brainstem","volume":"520","author":"Korn","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C65","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1002\/cne.24199","article-title":"Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons","volume":"525","author":"Korsak","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C66","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/neuro.04.011.2009","article-title":"Fragile X Mental Retardation Protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A","author":"Li","year":"2009","journal-title":"Front. Neural Circuits"},{"key":"2021042700580346400_DEV188797C67","doi-asserted-by":"publisher","first-page":"15281","DOI":"10.1073\/pnas.0804678105","article-title":"Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice","volume":"105","author":"Liao","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042700580346400_DEV188797C68","doi-asserted-by":"publisher","first-page":"e40232","DOI":"10.7554\/eLife.40232","article-title":"Conserved and divergent development of brainstem vestibular and auditory nuclei","volume":"7","author":"Lipovsek","year":"2018","journal-title":"eLife"},{"key":"2021042700580346400_DEV188797C69","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.brainres.2019.04.006","article-title":"Subtle differences in synaptic transmission in medial nucleus of trapezoid body neurons between wild-type and Fmr1 knockout mice","volume":"1717","author":"Lu","year":"2019","journal-title":"Brain Res."},{"key":"2021042700580346400_DEV188797C70","doi-asserted-by":"publisher","first-page":"e141","DOI":"10.1093\/nar\/gkp686","article-title":"PiggyBac transgenic strategies in the developing chicken spinal cord","volume":"37","author":"Lu","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2021042700580346400_DEV188797C71","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S1567-133X(03)00089-9","article-title":"Math1-driven GFP expression in the developing nervous system of transgenic mice","volume":"3","author":"Lumpkin","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"2021042700580346400_DEV188797C72","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2005.08.028","article-title":"Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors","volume":"48","author":"Machold","year":"2005","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C73","doi-asserted-by":"publisher","first-page":"11123","DOI":"10.1523\/JNEUROSCI.2232-09.2009","article-title":"Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei","volume":"29","author":"Maricich","year":"2009","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C74","doi-asserted-by":"publisher","first-page":"3543","DOI":"10.1002\/cne.24290","article-title":"Tonotopic alterations in inhibitory input to the medial nucleus of the trapezoid body in a mouse model of Fragile X syndrome","volume":"525","author":"McCullagh","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C75","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1096\/fj.201902435R","article-title":"Mechanisms underlying auditory processing deficits in Fragile X syndrome","volume":"34","author":"McCullagh","year":"2020","journal-title":"FASEB J."},{"key":"2021042700580346400_DEV188797C76","doi-asserted-by":"publisher","first-page":"5379","DOI":"10.1093\/nar\/gkm581","article-title":"Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family","volume":"35","author":"Menon","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2021042700580346400_DEV188797C77","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/0012-1606(89)90179-6","article-title":"Expression of L1 and N-CAM cell adhesion molecules during development of the mouse olfactory system","volume":"135","author":"Miragall","year":"1989","journal-title":"Dev. Biol."},{"key":"2021042700580346400_DEV188797C78","doi-asserted-by":"publisher","first-page":"9229","DOI":"10.1523\/JNEUROSCI.23-27-09229.2003","article-title":"The transmembrane semaphorin Sema4D\/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion","volume":"23","author":"Moreau-Fauvarque","year":"2003","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C79","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.neuron.2018.12.024","article-title":"Synergistic activity of floor-plate- and ventricular-zone-derived netrin-1 in spinal cord commissural axon guidance","volume":"101","author":"Moreno-Bravo","year":"2019","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C80","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1083\/jcb.107.3.1177","article-title":"N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro","volume":"107","author":"Neugebauer","year":"1988","journal-title":"J. Cell Biol."},{"key":"2021042700580346400_DEV188797C81","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1523\/JNEUROSCI.21-14-05139.2001","article-title":"Abnormal development of dendritic spines in FMR1 knock-out mice","volume":"21","author":"Nimchinsky","year":"2001","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2016.02.003","article-title":"Evolution of mammalian sound localization circuits: a developmental perspective","volume":"141","author":"Nothwang","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"2021042700580346400_DEV188797C83","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1523\/JNEUROSCI.12-05-01698.1992","article-title":"A circuit for coding interaural time differences in the chick brainstem","volume":"12","author":"Overholt","year":"1992","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C84","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.1093\/hmg\/ddt246","article-title":"Delayed myelination in a mouse model of fragile X syndrome","volume":"22","author":"Pacey","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"2021042700580346400_DEV188797C85","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1016\/j.cub.2004.09.085","article-title":"The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation","volume":"14","author":"Pan","year":"2004","journal-title":"Curr. Biol."},{"key":"2021042700580346400_DEV188797C88","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature05295","article-title":"In vivo enhancer analysis of human conserved non-coding sequences","volume":"444","author":"Pennacchio","year":"2006","journal-title":"Nature"},{"key":"2021042700580346400_DEV188797C89","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12915-016-0277-y","article-title":"A new role of hindbrain boundaries as pools of neural stem\/progenitor cells regulated by Sox2","volume":"14","author":"Peretz","year":"2016","journal-title":"BMC Biol."},{"key":"2021042700580346400_DEV188797C90","doi-asserted-by":"publisher","first-page":"13920","DOI":"10.1038\/s41598-018-32203-w","article-title":"Neural stem cells deriving from chick embryonic hindbrain recapitulate hindbrain development in culture","volume":"8","author":"Peretz","year":"2018","journal-title":"Sci. Rep."},{"key":"2021042700580346400_DEV188797C91","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1006\/geno.1996.0002","article-title":"The chicken FMR1 gene is highly conserved with a CCT 5\u2032-untranslated repeat and encodes an RNA-binding protein","volume":"31","author":"Price","year":"1996","journal-title":"Genomics"},{"key":"2021042700580346400_DEV188797C92","doi-asserted-by":"publisher","first-page":"1759091418801092","DOI":"10.1177\/1759091418801092","article-title":"Sensory processing phenotypes in fragile X syndrome","volume":"10","author":"Rais","year":"2018","journal-title":"ASN Neuro"},{"key":"2021042700580346400_DEV188797C93","doi-asserted-by":"publisher","first-page":"8698","DOI":"10.1523\/JNEUROSCI.1479-08.2008","article-title":"Manipulating Robo expression in vivo perturbs commissural axon pathfinding in the chick spinal cord","volume":"28","author":"Reeber","year":"2008","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C94","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fnins.2020.00203","article-title":"Glial cell-axonal growth cone interactions in neurodevelopment and regeneration","volume":"14","author":"Rigby","year":"2020","journal-title":"Front. Neurosci."},{"key":"2021042700580346400_DEV188797C95","doi-asserted-by":"publisher","first-page":"e0117266","DOI":"10.1371\/journal.pone.0117266","article-title":"Deletion of Fmr1 alters function and synaptic inputs in the auditory brainstem","volume":"10","author":"Rotschafer","year":"2015","journal-title":"PLoS ONE"},{"key":"2021042700580346400_DEV188797C96","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fncir.2016.00084","article-title":"Axonal cleaved caspase-3 regulates axon targeting and morphogenesis in the developing auditory brainstem","volume":"10","author":"Rotschafer","year":"2016","journal-title":"Front. Neural Circuits"},{"key":"2021042700580346400_DEV188797C97","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.neuro.25.112701.142849","article-title":"Auditory system development: primary auditory neurons and their targets","volume":"25","author":"Rubel","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"key":"2021042700580346400_DEV188797C98","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/cne.901660408","article-title":"Organization and development of brain stem auditory nuclei of the chicken: ontogeny of N. magnocellularis and N. laminaris","volume":"166","author":"Rubel","year":"1976","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C99","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neuroscience.2015.06.061","article-title":"Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats","volume":"303","author":"Ruby","year":"2015","journal-title":"Neuroscience"},{"key":"2021042700580346400_DEV188797C100","doi-asserted-by":"publisher","first-page":"5400","DOI":"10.1038\/srep05400","article-title":"Multiplex genome engineering in human cells using all-in-one CRISPR\/Cas9 vector system","volume":"4","author":"Sakuma","year":"2014","journal-title":"Sci. Rep."},{"key":"2021042700580346400_DEV188797C101","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1093\/cercor\/bhw408","article-title":"Altered connectivity and synapse maturation of the hippocampal mossy fiber pathway in a mouse model of the fragile X syndrome","volume":"28","author":"Scharkowski","year":"2018","journal-title":"Cereb. Cortex"},{"key":"2021042700580346400_DEV188797C102","doi-asserted-by":"publisher","first-page":"14000","DOI":"10.1523\/JNEUROSCI.2274-12.2012","article-title":"TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis","volume":"32","author":"Schecterson","year":"2012","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C103","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3389\/fnmol.2017.00440","article-title":"Fragile X mental retardation protein regulates activity-dependent membrane trafficking and trans-synaptic signaling mediating synaptic remodeling","volume":"10","author":"Sears","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"2021042700580346400_DEV188797C104","doi-asserted-by":"publisher","first-page":"4914","DOI":"10.1523\/JNEUROSCI.5460-13.2014","article-title":"Differential conduction velocity regulation in ipsilateral and contralateral collaterals innervating brainstem coincidence detector neurons","volume":"34","author":"Seidl","year":"2014","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C105","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/S0092-8674(00)81795-X","article-title":"Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system","volume":"87","author":"Serafini","year":"1996","journal-title":"Cell"},{"key":"2021042700580346400_DEV188797C106","doi-asserted-by":"publisher","first-page":"e1005702","DOI":"10.1371\/journal.pgen.1005702","article-title":"Fmrp interacts with adar and regulates RNA editing, synaptic density and locomotor activity in Zebrafish","volume":"11","author":"Shamay-Ramot","year":"2015","journal-title":"PLoS Genet."},{"key":"2021042700580346400_DEV188797C107","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/cne.24772","article-title":"Axonal localization of the fragile X family of RNA binding proteins is conserved across mammals","volume":"528","author":"Shepard","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C108","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.mcn.2012.04.007","article-title":"PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition","volume":"50","author":"Shim","year":"2012","journal-title":"Mol. Cell. Neurosci."},{"key":"2021042700580346400_DEV188797C109","doi-asserted-by":"publisher","first-page":"e19907","DOI":"10.7554\/eLife.19907","article-title":"Axon tension regulates fasciculation\/defasciculation through the control of axon shaft zippering","volume":"6","author":"\u0160m\u00edt","year":"2017","journal-title":"eLife"},{"key":"2021042700580346400_DEV188797C110","doi-asserted-by":"publisher","first-page":"dev151415","DOI":"10.1242\/dev.151415","article-title":"Understanding axon guidance: are we nearly there yet?","volume":"145","author":"Stoeckli","year":"2018","journal-title":"Development"},{"key":"2021042700580346400_DEV188797C111","doi-asserted-by":"publisher","first-page":"10263","DOI":"10.1523\/JNEUROSCI.1125-10.2010","article-title":"Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b","volume":"30","author":"Strumbos","year":"2010","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C112","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1242\/dev.015867","article-title":"Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning","volume":"135","author":"Tessier","year":"2008","journal-title":"Development"},{"key":"2021042700580346400_DEV188797C113","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.neuron.2017.03.007","article-title":"Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord","volume":"94","author":"Varadarajan","year":"2017","journal-title":"Neuron"},{"key":"2021042700580346400_DEV188797C114","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.tins.2014.03.002","article-title":"Detecting interaural time differences and remodeling their representation","volume":"37","author":"Vonderschen","year":"2014","journal-title":"Trends Neurosci."},{"key":"2021042700580346400_DEV188797C115","doi-asserted-by":"publisher","first-page":"11495","DOI":"10.1523\/JNEUROSCI.1737-12.2012","article-title":"In vivo reversible regulation of dendritic patterning by afferent input in bipolar auditory neurons","volume":"32","author":"Wang","year":"2012","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C116","doi-asserted-by":"publisher","first-page":"410","DOI":"10.2144\/000112255","article-title":"Extraction of DNA from mouse tails","volume":"41","author":"Wang","year":"2006","journal-title":"BioTechniques"},{"key":"2021042700580346400_DEV188797C117","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1101\/gr.085621.108","article-title":"A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells","volume":"19","author":"Wang","year":"2009","journal-title":"Genome Res."},{"key":"2021042700580346400_DEV188797C118","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1365-2583.2009.00964.x","article-title":"piggyBac-like elements in the pink bollworm, Pectinophora gossypiella","volume":"19","author":"Wang","year":"2010","journal-title":"Insect Mol. Biol."},{"key":"2021042700580346400_DEV188797C119","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1002\/cne.23520","article-title":"Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons: a comparative study in the alligator, chicken, gerbil, and human","volume":"522","author":"Wang","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C120","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3389\/fncel.2015.00234","article-title":"In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"2021042700580346400_DEV188797C121","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1016\/j.celrep.2015.11.057","article-title":"FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1","volume":"13","author":"Wang","year":"2015","journal-title":"Cell Rep."},{"key":"2021042700580346400_DEV188797C122","doi-asserted-by":"publisher","first-page":"ENEURO.0016-17.2017.","DOI":"10.1523\/ENEURO.0016-17.2017","article-title":"Distinct neural properties in the low-frequency region of the chicken cochlear nucleus magnocellularis","volume":"4","author":"Wang","year":"2017","journal-title":"eNeuro"},{"key":"2021042700580346400_DEV188797C123","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1523\/JNEUROSCI.0665-18.2018","article-title":"Postsynaptic FMRP regulates synaptogenesis in vivo in the developing cochlear nucleus","volume":"38","author":"Wang","year":"2018","journal-title":"J. Neurosci."},{"key":"2021042700580346400_DEV188797C124","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1242\/bio.2011032","article-title":"Expression of hindbrain boundary markers is regulated by FGF3","volume":"1","author":"Weisinger","year":"2012","journal-title":"Biol. Open"},{"key":"2021042700580346400_DEV188797C125","doi-asserted-by":"publisher","first-page":"e00673-19","DOI":"10.1128\/mBio.00673-19","article-title":"Live monitoring and analysis of fungal growth, viability, and mycelial morphology using the IncuCyte NeuroTrack processing module","volume":"10","author":"Wurster","year":"2019","journal-title":"mBio"},{"key":"2021042700580346400_DEV188797C126","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1152\/jn.00617.2016","article-title":"Activity-dependent formation and location of voltage-gated sodium channel clusters at a CNS nerve terminal during postnatal development","volume":"117","author":"Xu","year":"2017","journal-title":"J. Neurophysiol."},{"key":"2021042700580346400_DEV188797C128","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/cne.902540402","article-title":"Embryogenesis of arborization pattern and topography of individual axons in N. Laminaris of the chicken brain stem","volume":"254","author":"Young","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C129","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24959","article-title":"Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation","author":"Yu","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"2021042700580346400_DEV188797C130","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1016\/j.celrep.2018.01.068","article-title":"Netrin-1 confines rhombic lip-derived neurons to the CNS","volume":"22","author":"Yung","year":"2018","journal-title":"Cell Rep."},{"key":"2021042700580346400_DEV188797C131","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/dneu.22453","article-title":"Splice form-dependent regulation of axonal arbor complexity by FMRP","volume":"77","author":"Zimmer","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"2021042700580346400_DEV188797C132","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1002\/cne.24100","article-title":"Cellular distribution of the fragile X mental retardation protein in the mouse brain","volume":"525","author":"Zorio","year":"2017","journal-title":"J. Comp. Neurol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.188797","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.188797\/1970042\/dev188797.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.188797\/2065087\/dev_188797v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.188797\/2065087\/dev_188797v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T22:52:19Z","timestamp":1621378339000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/doi\/10.1242\/dev.188797\/266982\/Temporal-specific-roles-of-Fragile-X-mental"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":129,"URL":"https:\/\/doi.org\/10.1242\/dev.188797","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"type":"electronic","value":"1477-9129"},{"type":"print","value":"0950-1991"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"article-number":"dev.188797"}}