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Here we reveal, that both EPO and EPOR are expressed in the developing rat somatosensory cortex during radial migration and laminar positioning of granular and supragranular neurons. Experimental deregulation of EPO signaling using genetic approaches results in aberrant migration as well as permanent neuronal misplacement leading to abnormal network activity and protracted sensory behavioral deficits. We identify ERK as the downstream effector of the EPO signaling pathway for neuronal migration. These findings reveal a critical role for endogenous EPO signaling in neuronal migration and offer important insights for understanding how temporary deregulation of EPO could results in migration defects leading to abnormal behavior in the adult.<\/jats:p>","DOI":"10.1242\/dev.190249","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T15:29:42Z","timestamp":1596727782000},"source":"Crossref","is-referenced-by-count":6,"title":["Endogenous erythropoietin signaling regulates migration and laminar positioning of upper-layer neurons in the developing neocortex"],"prefix":"10.1242","author":[{"given":"Paul E.","family":"Constanthin","sequence":"first","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6528-1403","authenticated-orcid":false,"given":"Alessandro","family":"Contestabile","sequence":"additional","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr","family":"Petrenko","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Internal Medicine Specialties, University Hospital of Geneva, 1201 Geneva, Switzerland"},{"name":"Department of Cell Physiology and Metabolism; Diabetes Center, Faculty of Medicine, University of Geneva; Institute of Genetics and Genomics in Geneva (iGE3), 1201 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Quairiaux","sequence":"additional","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra S.","family":"H\u00fcppi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University Hospital of Geneva, 1201 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2809-4788","authenticated-orcid":false,"given":"Jozsef Z.","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042700391083800_DEV190249C1","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3892\/mmr.2014.2044","article-title":"Co-stimulation with stem cell factor and erythropoietin enhances migration of c-Kit expressing cervical cancer cells through the sustained activation of ERK1\/2","volume":"9","author":"Aguilar","year":"2014","journal-title":"Mol. 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