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Developmental modules (Raff, 1996) comprise discrete units specified by self-sufficient genetic programs that can interact among each other during embryogenesis. Here we took advantage of the different span of embryonic development between two far related teleosts, zebrafish (Danio rerio) and medaka (Oryzias latipes), of 3 and 9 days respectively, to explore modularity principles. We report that inter-species blastula transplantations result in the ectopic formation of a retina formed by donor cells \u2014 a module. We show that the developmental time of the retina follows a genetic program: an ectopic zebrafish retina in medaka develops with zebrafish dynamics. Heterologous transplantation results in a temporal decoupling between the donor retina and host organism, illustrated by two paradigms that require retina-host interactions: lens recruitment and retino-tectal projections. Our results uncover a new experimental system to address temporal decoupling along embryonic development, and highlight the presence of largely autonomous but yet interconnected developmental modules orchestrating organogenesis.<\/jats:p>","DOI":"10.1242\/dev.192500","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T10:16:51Z","timestamp":1602152211000},"source":"Crossref","is-referenced-by-count":10,"title":["Genetic developmental timing revealed by inter-species transplantations in fish"],"prefix":"10.1242","author":[{"given":"Jana Franziska","family":"Fuhrmann","sequence":"first","affiliation":[{"name":"Lab of Clonal Analysis, Center for Organismal Studies, Universit\u00e4t Heidelberg, INF230, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Buono","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo, Universidad Pablo de Olavide, Carretera de Utrera km 1, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Adelmann","sequence":"additional","affiliation":[{"name":"Lab of Clonal Analysis, Center for Organismal Studies, Universit\u00e4t Heidelberg, INF230, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Ram\u00f3n Martinez","family":"Morales","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo, Universidad Pablo de Olavide, Carretera de Utrera km 1, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-4524","authenticated-orcid":false,"given":"L\u00e1zaro","family":"Centanin","sequence":"additional","affiliation":[{"name":"Lab of Clonal Analysis, Center for Organismal Studies, Universit\u00e4t Heidelberg, INF230, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2021042700503719700_DEV192500C1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/bs.ctdb.2015.11.023","article-title":"Chapter twenty-six - organizers in development","volume":"117","author":"Anderson","year":"2016","journal-title":"Curr. 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