{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:43:56Z","timestamp":1784619836985,"version":"3.55.0"},"reference-count":73,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2018-05673"],"award-info":[{"award-number":["RGPIN-2018-05673"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fonds de recherche du Qu\u00e9bec\u2013Sant\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The evolutionarily conserved LIN-2 (CASK)\/LIN-7 (Lin7A-C)\/LIN-10 (APBA1) complex plays an important role in regulating spatial organization of membrane proteins and signaling components. In Caenorhabditis elegans, the complex is essential for the development of the vulva by promoting the localization of the sole Epidermal growth factor receptor (EGFR) ortholog LET-23 to the basolateral membrane of the vulva precursor cells where it can specify the vulval cell fate. To understand how the LIN-2\/7\/10 complex regulates receptor localization, we determined its expression and localization during vulva development. We found that LIN-7 colocalizes with LET-23 EGFR at the basolateral membrane, whereas the LIN-2\/7\/10 complex colocalizes with LET-23 EGFR at cytoplasmic punctae that mostly overlap with the Golgi. Furthermore, LIN-10 recruits LIN-2, which in turn recruits LIN-7. We demonstrate that the complex forms in vivo with a particularly strong interaction and colocalization between LIN-2 and LIN-7, consistent with them forming a subcomplex. Thus, the LIN-2\/7\/10 complex forms on the Golgi on which it likely targets LET-23 EGFR trafficking to the basolateral membrane rather than functioning as a tether.<\/jats:p>","DOI":"10.1242\/dev.194167","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T13:37:09Z","timestamp":1612186629000},"source":"Crossref","is-referenced-by-count":11,"title":["Golgi localization of the LIN-2\/7\/10 complex points to a role in basolateral secretion of LET-23 EGFR in the\n                    <i>Caenorhabditis elegans<\/i>\n                    vulval precursor cells"],"prefix":"10.1242","volume":"148","author":[{"given":"Kimberley D.","family":"Gauthier","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, and Department of Anatomy and Cell Biology, McGill University; and the Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-5636","authenticated-orcid":false,"given":"Christian E.","family":"Rocheleau","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, and Department of Anatomy and Cell Biology, McGill University; and the Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"2021042701122717900_DEV194167C1","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1242\/dev.068148","article-title":"Notch and Ras promote sequential steps of excretory tube development in C. elegans","volume":"138","author":"Abdus-Saboor","year":"2011","journal-title":"Development"},{"key":"2021042701122717900_DEV194167C2","doi-asserted-by":"publisher","first-page":"C1733","DOI":"10.1152\/ajpcell.00323.2007","article-title":"Lin-7 targets the Kir 2.3 channel on the basolateral membrane via a L27 domain interaction with CASK","volume":"293","author":"Alewine","year":"2007","journal-title":"Am. 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