{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:17:50Z","timestamp":1784675870217,"version":"3.55.0"},"reference-count":53,"publisher":"The Company of Biologists","issue":"22","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32HL007185"],"award-info":[{"award-number":["T32HL007185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35GM122548"],"award-info":[{"award-number":["R35GM122548"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal air sac primordium (ASP) and myoblasts. Hh distributes in concentration gradients in the anterior compartment of the wing disc, ASP and myoblasts, and activates genes in each tissue. Some targets of Hh signal transduction are common to the disc, ASP and myoblasts, whereas others are tissue-specific. Signaling in the three tissues is cytoneme-mediated and cytoneme-dependent. Some ASP cells project cytonemes that receive both Hh and Branchless (Bnl), and some targets regulated by Hh signaling in the ASP are also dependent on Bnl signal transduction. We conclude that the single source of Hh in the wing disc regulates cell type-specific responses in three discreet target tissues.<\/jats:p>","DOI":"10.1242\/dev.195974","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T11:42:27Z","timestamp":1602070947000},"source":"Crossref","is-referenced-by-count":15,"title":["Hedgehog produced by the\n                    <i>Drosophila<\/i>\n                    wing imaginal disc induces distinct responses in three target tissues"],"prefix":"10.1242","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-5802","authenticated-orcid":false,"given":"Ryo","family":"Hatori","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-7066","authenticated-orcid":false,"given":"Thomas B.","family":"Kornberg","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"2022042909324179000_DEV195974C1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nature15730","article-title":"Decapentaplegic and growth control in the developing Drosophila wing","volume":"527","author":"Akiyama","year":"2015","journal-title":"Nature"},{"key":"2022042909324179000_DEV195974C2","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/S0092-8674(00)80292-5","article-title":"Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor","volume":"89","author":"Aza-Blanc","year":"1997","journal-title":"Cell"},{"key":"2022042909324179000_DEV195974C3","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.ydbio.2009.01.006","article-title":"Genetic and epigenetic mechanisms regulating hedgehog expression in the Drosophila wing","volume":"327","author":"Bejarano","year":"2009","journal-title":"Dev. 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