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In Caenorhabditis elegans, this reprogramming is mediated by the H3K4me2 demethylase SPR-5 and the H3K9 methyltransferase, MET-2. In contrast, the H3K36 methyltransferase MES-4 maintains H3K36me2\/3 at germline genes between generations to facilitate re-establishment of the germline. To determine whether the MES-4 germline inheritance pathway antagonizes spr-5; met-2 reprogramming, we examined the interaction between these two pathways. We found that the developmental delay of spr-5; met-2 mutant progeny is associated with ectopic H3K36me3 and the ectopic expression of MES-4-targeted germline genes in somatic tissues. Furthermore, the developmental delay is dependent upon MES-4 and the H3K4 methyltransferase, SET-2. We propose that MES-4 prevents crucial germline genes from being repressed by antagonizing maternal spr-5; met-2 reprogramming. Thus, the balance of inherited histone modifications is necessary to distinguish germline versus soma and prevent developmental delay.<\/jats:p>\n                  <jats:p>This article has an associated \u2018The people behind the papers\u2019 interview.<\/jats:p>","DOI":"10.1242\/dev.196600","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T11:38:50Z","timestamp":1610969930000},"source":"Crossref","is-referenced-by-count":24,"title":["<i>Caenorhabditis elegans<\/i>\n                    establishes germline versus soma by balancing inherited histone methylation"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-1926","authenticated-orcid":false,"given":"Brandon S.","family":"Carpenter","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0149-5389","authenticated-orcid":false,"given":"Teresa W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline F.","family":"Plott","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovan S.","family":"Brockett","sequence":"additional","affiliation":[{"name":"Department of Biology, Oglethorpe University, Atlanta GA 30319, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexter A.","family":"Myrick","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-1142","authenticated-orcid":false,"given":"David J.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"2022042909324407400_DEV196600C1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/acel.12166","article-title":"H3K4 demethylase activities repress proliferative and postmitotic aging","volume":"13","author":"Alvares","year":"2014","journal-title":"Aging Cell"},{"key":"2022042909324407400_DEV196600C2","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.7554\/eLife.08851","article-title":"Maternal LSD1\/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation","volume":"5","author":"Ancelin","year":"2016","journal-title":"Elife"},{"key":"2022042909324407400_DEV196600C3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cell.2012.06.018","article-title":"piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans","volume":"150","author":"Ashe","year":"2012","journal-title":"Cell"},{"key":"2022042909324407400_DEV196600C4","doi-asserted-by":"publisher","first-page":"17732","DOI":"10.1074\/jbc.M500796200","article-title":"Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes","volume":"280","author":"Bannister","year":"2005","journal-title":"J. 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