{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:45:08Z","timestamp":1783064708123,"version":"3.54.6"},"reference-count":75,"publisher":"The Company of Biologists","issue":"24","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20gm6110016"],"award-info":[{"award-number":["JP20gm6110016"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adult tissues contain label-retaining cells (LRCs), which are relatively slow-cycling and considered to represent a property of tissue stem cells (SCs). In the ocular surface epithelium, LRCs are present in the limbus and conjunctival fornix; however, the character of these LRCs remains unclear, owing to lack of appropriate molecular markers. Using three CreER transgenic mouse lines, we demonstrate that the ocular surface epithelium accommodates spatially distinct populations with different cell division dynamics. In the limbus, long-lived Slc1a3CreER-labeled SCs either migrate centripetally toward the central cornea or slowly expand their clones laterally within the limbal region. In the central cornea, non-LRCs labeled with Dlx1CreER and K14CreER behave as short-lived progenitor cells. The conjunctival epithelium in the bulbar, fornix and palpebral compartment is regenerated by regionally unique SC populations. Severe damage to the cornea leads to the cancellation of SC compartments and conjunctivalization, whereas milder limbal injury induces a rapid increase of laterally expanding clones in the limbus. Taken together, our work defines compartmentalized multiple SC\/progenitor populations of the mouse eye in homeostasis and their behavioral changes in response to injury.<\/jats:p>","DOI":"10.1242\/dev.197590","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T12:40:21Z","timestamp":1605530421000},"source":"Crossref","is-referenced-by-count":18,"title":["Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium"],"prefix":"10.1242","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-6354","authenticated-orcid":false,"given":"Ryutaro","family":"Ishii","sequence":"first","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 1 , Tsukuba 305-8577 ,","place":["Japan"]},{"name":"Graduate School of Comprehensive Human Sciences, University of Tsukuba 2 , Tsukuba 305-8577 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7576-9186","authenticated-orcid":false,"given":"Hiromi","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 1 , Tsukuba 305-8577 ,","place":["Japan"]},{"name":"University of Tsukuba 3 Faculty of Medicine , , Tsukuba 305-8577 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0984-4280","authenticated-orcid":false,"given":"Aiko","family":"Sada","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 1 , Tsukuba 305-8577 ,","place":["Japan"]},{"name":"International Research Center for Medical Sciences (IRCMS) 4 , , Kumamoto 860-0811 ,","place":["Japan"]},{"name":"Kumamoto University 4 , , Kumamoto 860-0811 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"2024102213203595900_DEV197590C1","doi-asserted-by":"publisher","first-page":"4658","DOI":"10.3791\/54658","article-title":"A simple mechanical procedure to create limbal stem cell deficiency in mouse","volume":"117","author":"Afsharkhamseh","year":"2016","journal-title":"J. Vis. Exp."},{"key":"2024102213203595900_DEV197590C2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.30.179754","article-title":"Capturing limbal epithelial stem cell population dynamics, signature, and their niche","volume-title":"bioRxiv","author":"Altshuler","year":"2020"},{"key":"2024102213203595900_DEV197590C3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/stem.1840","article-title":"Lineage tracing of stem and progenitor cells of the murine corneal epithelium","volume":"33","author":"Amitai-Lange","year":"2015","journal-title":"Stem Cells"},{"key":"2024102213203595900_DEV197590C4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.4274\/tjo.72593","article-title":"Limbal stem cell deficiency and treatment with stem cell transplantation","volume":"47","author":"Barut Selver","year":"2017","journal-title":"Turk J. Ophthalmol."},{"key":"2024102213203595900_DEV197590C5","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1387\/ijdb.170341fw","article-title":"Homeostasis, regeneration and tumour formation in the mammalian epidermis","volume":"62","author":"Belokhvostova","year":"2018","journal-title":"Int. J. Dev. Biol."},{"key":"2024102213203595900_DEV197590C6","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00429-006-0109-x","article-title":"Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs","volume":"211","author":"Berger","year":"2006","journal-title":"Anat. Embryol."},{"key":"2024102213203595900_DEV197590C7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.cmet.2018.09.012","article-title":"Tumor-stroma mechanics coordinate amino acid availability to sustain tumor growth and malignancy","volume":"29","author":"Bertero","year":"2019","journal-title":"Cell Metab."},{"key":"2024102213203595900_DEV197590C8","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1177\/002203458106000311011","article-title":"Identification and behavior of label-retaining cells in oral mucosa and skin","volume":"60","author":"Bickenbach","year":"1981","journal-title":"J. Dent. Res."},{"key":"2024102213203595900_DEV197590C9","doi-asserted-by":"publisher","first-page":"5241","DOI":"10.1242\/dev.00703","article-title":"Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis","volume":"130","author":"Braun","year":"2003","journal-title":"Development"},{"key":"2024102213203595900_DEV197590C10","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1242\/jcs.02279","article-title":"Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells","volume":"118","author":"Budak","year":"2005","journal-title":"J. Cell Sci."},{"key":"2024102213203595900_DEV197590C11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.stem.2019.11.005","article-title":"Heterogeneity within stratified epithelial stem cell populations maintains the oral mucosa in response to physiological stress","volume":"25","author":"Byrd","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2024102213203595900_DEV197590C12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0021-5155(02)00687-1","article-title":"Wistar rat palpebral conjunctiva contains more slow-cycling stem cells that have larger proliferative capacity: implication for conjunctival epithelial homeostasis","volume":"47","author":"Chen","year":"2003","journal-title":"Jpn. J. Ophthalmol."},{"key":"2024102213203595900_DEV197590C13","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/00003226-199903000-00013","article-title":"Conjunctival epithelial cells cultured on human amniotic membrane fail to transdifferentiate into corneal epithelial-type cells","volume":"18","author":"Cho","year":"1999","journal-title":"Cornea"},{"key":"2024102213203595900_DEV197590C14","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature05574","article-title":"A single type of progenitor cell maintains normal epidermis","volume":"446","author":"Clayton","year":"2007","journal-title":"Nature"},{"key":"2024102213203595900_DEV197590C15","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1002\/1873-3468.13608","article-title":"The paradox of metabolism in quiescent stem cells","volume":"593","author":"Coller","year":"2019","journal-title":"FEBS Lett."},{"key":"2024102213203595900_DEV197590C16","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.cmet.2016.03.016","article-title":"Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells","volume":"23","author":"Coloff","year":"2016","journal-title":"Cell Metab."},{"key":"2024102213203595900_DEV197590C17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","article-title":"Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells","volume":"57","author":"Cotsarelis","year":"1989","journal-title":"Cell"},{"key":"2024102213203595900_DEV197590C18","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/0092-8674(90)90696-C","article-title":"Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis","volume":"61","author":"Cotsarelis","year":"1990","journal-title":"Cell"},{"key":"2024102213203595900_DEV197590C19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41556-018-0237-6","article-title":"Stem cell dynamics, migration and plasticity during wound healing","volume":"21","author":"Dekoninck","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"2024102213203595900_DEV197590C20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/stem.1769","article-title":"Tracing the fate of limbal epithelial progenitor cells in the murine cornea","volume":"33","author":"Di Girolamo","year":"2015","journal-title":"Stem Cells"},{"key":"2024102213203595900_DEV197590C21","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.scr.2015.10.016","article-title":"Lineage tracing in the adult mouse corneal epithelium supports the limbal epithelial stem cell hypothesis with intermittent periods of stem cell quiescence","volume":"15","author":"Dor\u00e0","year":"2015","journal-title":"Stem Cell Res."},{"key":"2024102213203595900_DEV197590C22","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.devcel.2009.12.016","article-title":"The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate","volume":"18","author":"Doup\u00e9","year":"2010","journal-title":"Dev. Cell"},{"key":"2024102213203595900_DEV197590C23","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1126\/science.1218835","article-title":"A single progenitor population switches behavior to maintain and repair esophageal epithelium","volume":"337","author":"Doup\u00e9","year":"2012","journal-title":"Science"},{"key":"2024102213203595900_DEV197590C24","first-page":"1533","article-title":"Comparison of limbal and peripheral human corneal epithelium in tissue culture","volume":"29","author":"Ebato","year":"1988","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nbt.1517","article-title":"Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells","volume":"27","author":"Foudi","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"2024102213203595900_DEV197590C26","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cell.2009.05.002","article-title":"The tortoise and the hair: slow-cycling cells in the stem cell race","volume":"137","author":"Fuchs","year":"2009","journal-title":"Cell"},{"key":"2024102213203595900_DEV197590C27","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.stemcr.2015.09.013","article-title":"Dynamics of Lgr6+ Progenitor cells in the hair follicle, sebaceous gland, and interfollicular epidermis","volume":"5","author":"F\u00fcllgrabe","year":"2015","journal-title":"Stem Cell Rep."},{"key":"2024102213203595900_DEV197590C28","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/s41556-018-0118-z","article-title":"Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours","volume":"20","author":"Garcia-Bermudez","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"2024102213203595900_DEV197590C29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.stemcr.2013.04.001","article-title":"The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1","volume":"1","author":"Gomez","year":"2013","journal-title":"Stem Cell Rep."},{"key":"2024102213203595900_DEV197590C30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/bs.pmbts.2015.04.002","article-title":"Stem cells in the cornea","volume":"134","author":"Hertsenberg","year":"2015","journal-title":"Prog. Mol. Biol. Transl Sci."},{"key":"2024102213203595900_DEV197590C31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.stem.2018.10.015","article-title":"Quantitative clonal analysis and single-cell transcriptomics reveal division kinetics, hierarchy, and fate of oral epithelial progenitor cells","volume":"24","author":"Jones","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2024102213203595900_DEV197590C32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1167\/iovs.01-1277","article-title":"VEGF-dependent conjunctivalization of the corneal surface","volume":"44","author":"Joussen","year":"2003","journal-title":"Invest. Opthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C33","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/stem.2767","article-title":"Bmi1+ progenitor cell dynamics in murine cornea during homeostasis and wound healing","volume":"36","author":"Kalha","year":"2018","journal-title":"Stem Cells"},{"key":"2024102213203595900_DEV197590C34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00424-003-1146-4","article-title":"The glutamate\/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects","volume":"447","author":"Kanai","year":"2004","journal-title":"Pflugers Arch."},{"key":"2024102213203595900_DEV197590C35","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.1167\/iovs.19-27656","article-title":"Single-cell RNA transcriptome helps define the limbal\/corneal epithelial stem\/early transit amplifying cells and how autophagy affects this population","volume":"60","author":"Kaplan","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C36","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.celrep.2015.12.041","article-title":"Compartmentalized epidermal activation of \u03b2-catenin differentially affects lineage reprogramming and underlies tumor heterogeneity","volume":"14","author":"Kretzschmar","year":"2016","journal-title":"Cell Rep"},{"key":"2024102213203595900_DEV197590C37","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1242\/dev.101063","article-title":"Dynamic stem cell heterogeneity","volume":"142","author":"Krieger","year":"2015","journal-title":"Development"},{"key":"2024102213203595900_DEV197590C38","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/sj.eye.6700575","article-title":"Epithelial stem cells: the eye provides a vision","volume":"17","author":"Lavker","year":"2003","journal-title":"Eye"},{"key":"2024102213203595900_DEV197590C39","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.exer.2003.09.008","article-title":"Corneal epithelial stem cells at the limbus: looking at some old problems from a new angle","volume":"78","author":"Lavker","year":"2004","journal-title":"Exp. Eye Res."},{"key":"2024102213203595900_DEV197590C40","doi-asserted-by":"publisher","first-page":"5169","DOI":"10.1038\/s41598-017-04569-w","article-title":"Identification for differential localization of putative corneal epithelial stem cells in mouse and human","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"2024102213203595900_DEV197590C41","doi-asserted-by":"publisher","first-page":"12388","DOI":"10.1038\/ncomms12388","article-title":"Self-organized centripetal movement of corneal epithelium in the absence of external cues","volume":"7","author":"Lobo","year":"2016","journal-title":"Nat. Commun."},{"key":"2024102213203595900_DEV197590C42","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2024102213203595900_DEV197590C43","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/nature07406","article-title":"Oligopotent stem cells are distributed throughout the mammalian ocular surface","volume":"456","author":"Majo","year":"2008","journal-title":"Nature"},{"key":"2024102213203595900_DEV197590C44","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/nature11393","article-title":"Distinct contribution of stem and progenitor cells to epidermal maintenance","volume":"489","author":"Mascr\u00e9","year":"2012","journal-title":"Nature"},{"key":"2024102213203595900_DEV197590C45","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.celrep.2017.12.040","article-title":"Corneal-committed cells restore the stem cell pool and tissue boundary following injury","volume":"22","author":"Nasser","year":"2018","journal-title":"Cell Rep."},{"key":"2024102213203595900_DEV197590C46","author":"Nathans","year":"2010"},{"key":"2024102213203595900_DEV197590C47","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.stem.2013.07.010","article-title":"The epidermis comprises autonomous compartments maintained by distinct stem cell populations","volume":"13","author":"Page","year":"2013","journal-title":"Cell Stem Cell"},{"key":"2024102213203595900_DEV197590C48","doi-asserted-by":"publisher","first-page":"7338","DOI":"10.1167\/iovs.15-18038","article-title":"Immunofluorescence tomography of mouse ocular surface epithelial stem cells and their niche microenvironment","volume":"56","author":"Parfitt","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C49","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1083\/jcb.145.4.769","article-title":"Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface","volume":"145","author":"Pellegrini","year":"1999","journal-title":"J. Cell Biol."},{"key":"2024102213203595900_DEV197590C50","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1073\/pnas.061032098","article-title":"p63 identifies keratinocyte stem cells","volume":"98","author":"Pellegrini","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024102213203595900_DEV197590C51","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1038\/s41467-020-15258-0","article-title":"A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice","volume":"11","author":"Piedrafita","year":"2020","journal-title":"Nat. Commun."},{"key":"2024102213203595900_DEV197590C52","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1056\/NEJMoa0905955","article-title":"Limbal stem-cell therapy and long-term corneal regeneration","volume":"363","author":"Rama","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"2024102213203595900_DEV197590C53","doi-asserted-by":"publisher","first-page":"601731","DOI":"10.1155\/2015\/601731","article-title":"An update on ocular surface epithelial stem cells: cornea and conjunctiva","volume":"2015","author":"Ramos","year":"2015","journal-title":"Stem Cells Int."},{"key":"2024102213203595900_DEV197590C54","doi-asserted-by":"publisher","first-page":"e98280","DOI":"10.15252\/embj.201798280","article-title":"Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth","volume":"37","author":"Reichenbach","year":"2018","journal-title":"EMBO J."},{"key":"2024102213203595900_DEV197590C55","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jtos.2015.11.007","article-title":"Fate mapping mammalian corneal epithelia","volume":"14","author":"Richardson","year":"2016","journal-title":"Ocul. Surf."},{"key":"2024102213203595900_DEV197590C56","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.stemcr.2017.08.015","article-title":"Keratin-14-positive precursor cells spawn a population of migratory corneal epithelia that maintain tissue mass throughout life","volume":"9","author":"Richardson","year":"2017","journal-title":"Stem Cell Rep."},{"key":"2024102213203595900_DEV197590C57","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.tcb.2018.05.002","article-title":"Skin cell heterogeneity in development, wound healing, and cancer","volume":"28","author":"Rognoni","year":"2018","journal-title":"Trends Cell Biol."},{"key":"2024102213203595900_DEV197590C58","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/nature11218","article-title":"Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration","volume":"487","author":"Rompolas","year":"2012","journal-title":"Nature"},{"key":"2024102213203595900_DEV197590C59","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.15252\/embj.201693806","article-title":"Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling","volume":"35","author":"Roy","year":"2016","journal-title":"EMBO J."},{"key":"2024102213203595900_DEV197590C60","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/ncb3359","article-title":"Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin","volume":"18","author":"Sada","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"2024102213203595900_DEV197590C61","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/S0002-9440(10)62358-9","article-title":"Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali","volume":"166","author":"Saika","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2024102213203595900_DEV197590C62","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature19069","article-title":"Defining the clonal dynamics leading to mouse skin tumour initiation","volume":"536","author":"S\u00e1nchez-Dan\u00e9s","year":"2016","journal-title":"Nature"},{"key":"2024102213203595900_DEV197590C63","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/ng.165","article-title":"Bmi1 is expressed in vivo in intestinal stem cells","volume":"40","author":"Sangiorgi","year":"2008","journal-title":"Nat. Genet."},{"key":"2024102213203595900_DEV197590C64","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1038\/s41598-017-04006-y","article-title":"Characterization of slow cycling corneal limbal epithelial cells identifies putative stem cell markers","volume":"7","author":"Sartaj","year":"2017","journal-title":"Sci. Rep."},{"key":"2024102213203595900_DEV197590C65","first-page":"135","article-title":"Corneal re-epithelialization from the conjunctiva","volume":"21","author":"Shapiro","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C66","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.cmet.2018.07.005","article-title":"A role for p53 in the adaptation to glutamine starvation through the expression of SLC1A3","volume":"28","author":"Tajan","year":"2018","journal-title":"Cell Metab."},{"key":"2024102213203595900_DEV197590C67","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.neuron.2011.07.026","article-title":"A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex","volume":"71","author":"Taniguchi","year":"2011","journal-title":"Neuron"},{"key":"2024102213203595900_DEV197590C68","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1126\/science.1092436","article-title":"Defining the epithelial stem cell niche in skin","volume":"303","author":"Tumbar","year":"2004","journal-title":"Science"},{"key":"2024102213203595900_DEV197590C69","doi-asserted-by":"publisher","first-page":"8551","DOI":"10.1073\/pnas.96.15.8551","article-title":"The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin","volume":"96","author":"Vasioukhin","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024102213203595900_DEV197590C70","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1038\/s41467-020-18075-7","article-title":"Single cell transcriptomics of human epidermis identifies basal stem cell transition states","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"2024102213203595900_DEV197590C71","first-page":"1814","article-title":"In vitro growth and differentiation of rabbit bulbar, fornix, and palpebral conjunctival epithelia. Implications on conjunctival epithelial transdifferentiation and stem cells","volume":"34","author":"Wei","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C72","first-page":"236","article-title":"Label-retaining cells are preferentially located in fornical epithelium: implications on conjunctival epithelial homeostasis","volume":"36","author":"Wei","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C73","first-page":"523","article-title":"Rabbit conjunctival and corneal epithelial cells belong to two separate lineages","volume":"37","author":"Wei","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024102213203595900_DEV197590C74","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","article-title":"Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair","volume":"135","author":"Wilson","year":"2008","journal-title":"Cell"},{"key":"2024102213203595900_DEV197590C75","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.4161\/cc.9.8.11252","article-title":"Stem cell dynamics in mouse hair follicles: a story from cell division counting and single cell lineage tracing","volume":"9","author":"Zhang","year":"2010","journal-title":"Cell Cycle"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.197590","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.197590\/3571989\/dev197590.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.197590\/2065177\/dev_197590v2.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.197590\/3571989\/dev197590.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T09:21:53Z","timestamp":1729588913000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/147\/24\/dev197590\/226089\/Defining-compartmentalized-stem-cell-populations"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,15]]},"references-count":75,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,12,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.197590","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.23.156505","asserted-by":"object"}]},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,15]]},"article-number":"dev197590"}}