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Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal\/minimal drug availability to the fetus\/mother.<\/jats:p>","DOI":"10.1242\/dev.197673","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T13:05:02Z","timestamp":1619528702000},"source":"Crossref","is-referenced-by-count":8,"title":["The trophoblast clock controls transport across placenta in mice"],"prefix":"10.1242","volume":"148","author":[{"given":"C\u00e9cile","family":"Demarez","sequence":"first","affiliation":[{"name":"Institute of Neurobiology, Center of Brain, Behavior and Metabolism (CBBM), University of L\u00fcbeck. Marie-Curie-Stra\u00dfe, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Vinicius Monteiro","family":"De Assis","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Center of Brain, Behavior and Metabolism (CBBM), University of L\u00fcbeck. Marie-Curie-Stra\u00dfe, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5345-9048","authenticated-orcid":false,"given":"Markus","family":"Krohn","sequence":"additional","affiliation":[{"name":"Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of L\u00fcbeck. Marie-Curie-Stra\u00dfe, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahuel","family":"Ramella","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata (INIBIOLP), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, Calles 60 y 120, 1900 La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Schwaninger","sequence":"additional","affiliation":[{"name":"Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of L\u00fcbeck. Marie-Curie-Stra\u00dfe, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Oster","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Center of Brain, Behavior and Metabolism (CBBM), University of L\u00fcbeck. Marie-Curie-Stra\u00dfe, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-1686","authenticated-orcid":false,"given":"Mariana","family":"Astiz","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Center of Brain, Behavior and Metabolism (CBBM), University of L\u00fcbeck. Marie-Curie-Stra\u00dfe, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"2021042908351832500_DEV197673C1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1080\/07420520500180231","article-title":"Daily rhythms of P-glycoprotein expression in mice","volume":"22","author":"Ando","year":"2005","journal-title":"Chronobiol. 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