{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:32:23Z","timestamp":1792017143520,"version":"4.4.0"},"reference-count":144,"publisher":"The Company of Biologists","issue":"13","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The trachea delivers inhaled air into the lungs for gas exchange. Anomalies in tracheal development can result in life-threatening malformations, such as tracheoesophageal fistula and tracheomalacia. Given the limitations of current therapeutic approaches, development of technologies for the reconstitution of a three-dimensional trachea from stem cells is urgently required. Recently, single-cell sequencing technologies and quantitative analyses from cell to tissue scale have been employed to decipher the cellular basis of tracheal morphogenesis. In this Review, recent advances in mammalian tracheal development and the generation of tracheal tissues from pluripotent stem cells are summarized.<\/jats:p>","DOI":"10.1242\/dev.198192","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T16:26:41Z","timestamp":1625588801000},"source":"Crossref","is-referenced-by-count":31,"title":["Mammalian tracheal development and reconstruction: insights from <i>in vivo<\/i> and <i>in vitro<\/i> studies"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2938-1754","authenticated-orcid":false,"given":"Keishi","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Laboratory for Lung Development and Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe 650-0047, Japan"},{"name":"RIKEN BDR\u2013CuSTOM Joint Laboratory, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Center for Stem Cell & Organoid Medicine (CuSTOM), Perinatal Institute, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1905-9398","authenticated-orcid":false,"given":"Mitsuru","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Laboratory for Lung Development and Regeneration, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe 650-0047, Japan"},{"name":"RIKEN BDR\u2013CuSTOM Joint Laboratory, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"2021070616261572900_DEV198192C1","doi-asserted-by":"publisher","first-page":"e1002866","DOI":"10.1371\/journal.pgen.1002866","article-title":"Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system","volume":"8","author":"Arora","year":"2012","journal-title":"PLoS Genet."},{"key":"2021070616261572900_DEV198192C2","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/ng0697-174","article-title":"SOX9 directly regulates the type-II collagen gene","volume":"16","author":"Bell","year":"1997","journal-title":"Nat. Genet."},{"key":"2021070616261572900_DEV198192C3","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1242\/dev.013359","article-title":"R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis","volume":"135","author":"Bell","year":"2008","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/8792","article-title":"Sox9 is required for cartilage formation","volume":"22","author":"Bi","year":"1999","journal-title":"Nat. Genet."},{"key":"2021070616261572900_DEV198192C5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/dvdy.24219","article-title":"One shall become two: Separation of the esophagus and trachea from the common foregut tube","volume":"244","author":"Billmyre","year":"2015","journal-title":"Dev. Dyn."},{"key":"2021070616261572900_DEV198192C6","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1113\/jphysiol.2008.150763","article-title":"Congenital tracheal malformation in cystic fibrosis transmembrane conductance regulator-deficient mice","volume":"586","author":"Bonvin","year":"2008","journal-title":"J. Physiol."},{"key":"2021070616261572900_DEV198192C7","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1378\/chest.128.5.3391","article-title":"Tracheomalacia and bronchomalacia in children: incidence and patient characteristics","volume":"128","author":"Boogaard","year":"2005","journal-title":"Chest"},{"issue":"(16)","key":"2021070616261572900_DEV198192C8","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1242\/dev.110254","article-title":"Crucial requirement of ERK\/MAPK signaling in respiratory tract development","volume":"141","author":"Boucherat","year":"2014","journal-title":"Development"},{"issue":"(17)","key":"2021070616261572900_DEV198192C9","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1242\/dev.120469","article-title":"Epithelial inactivation of Yy1 abrogates lung branching morphogenesis","volume":"142","author":"Boucherat","year":"2015","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/dvdy.24464","article-title":"Lung development requires an active ERK\/MAPK pathway in the lung mesenchyme","volume":"246","author":"Boucherat","year":"2017","journal-title":"Dev. Dyn."},{"key":"2021070616261572900_DEV198192C11","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ydbio.2015.08.017","article-title":"Wnt4 is essential to normal mammalian lung development","volume":"406","author":"Caprioli","year":"2015","journal-title":"Dev Biol"},{"key":"2021070616261572900_DEV198192C12","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1378\/chest.127.3.984","article-title":"Tracheomalacia and tracheobronchomalacia in children and adults: an in-depth review","volume":"127","author":"Carden","year":"2005","journal-title":"Chest"},{"key":"2021070616261572900_DEV198192C13","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1242\/dev.02310","article-title":"Regulation of early lung morphogenesis: questions, facts and controversies","volume":"133","author":"Cardoso","year":"2006","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C14","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/ncb3510","article-title":"A three-dimensional model of human lung development and disease from pluripotent stem cells","volume":"19","author":"Chen","year":"2017","journal-title":"Nat. Cell. Biol."},{"key":"2021070616261572900_DEV198192C15","doi-asserted-by":"publisher","first-page":"e2000006","DOI":"10.1002\/bies.202000006","article-title":"Understanding human lung development through in vitro model systems","volume":"42","author":"Conway","year":"2020","journal-title":"BioEssays"},{"key":"2021070616261572900_DEV198192C16","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1242\/dev.053694","article-title":"Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2","volume":"138","author":"Domyan","year":"2011","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C17","doi-asserted-by":"publisher","first-page":"e05098","DOI":"10.7554\/eLife.05098","article-title":"In vitro generation of human pluripotent stem cell derived lung organoids","volume":"4","author":"Dye","year":"2015","journal-title":"eLife"},{"key":"2021070616261572900_DEV198192C18","doi-asserted-by":"publisher","first-page":"e19732","DOI":"10.7554\/eLife.19732","article-title":"A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids","volume":"5","author":"Dye","year":"2016","journal-title":"eLife"},{"key":"2021070616261572900_DEV198192C19","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.04.134338","article-title":"SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways","author":"Eenjes","year":"2020","journal-title":"BioRxiv"},{"key":"2021070616261572900_DEV198192C20","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1002\/lary.20157","article-title":"Fibroblast growth factor 18 gives growth and directional cues to airway cartilage","volume":"119","author":"Elluru","year":"2009","journal-title":"Laryngoscope"},{"key":"2021070616261572900_DEV198192C21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ydbio.2014.02.008","article-title":"BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis","volume":"391","author":"Fausett","year":"2014","journal-title":"Dev. Biol."},{"issue":"(17)","key":"2021070616261572900_DEV198192C22","doi-asserted-by":"publisher","first-page":"7058","DOI":"10.1073\/pnas.1007293108","article-title":"Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development","volume":"108","author":"Geng","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021070616261572900_DEV198192C23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ydbio.2018.02.002","article-title":"Notum attenuates Wnt\/\u03b2-catenin signaling to promote tracheal cartilage patterning","volume":"436","author":"Gerhardt","year":"2018","journal-title":"Dev Biol"},{"key":"2021070616261572900_DEV198192C24","doi-asserted-by":"publisher","first-page":"12182","DOI":"10.1073\/pnas.2002082117","article-title":"Redundant and additive functions of the four Lef\/Tcf transcription factors in lung epithelial progenitors","volume":"117","author":"Gerner-Mauro","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021070616261572900_DEV198192C25","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.devcel.2009.06.005","article-title":"Wnt2\/2b and \u03b2-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut","volume":"17","author":"Goss","year":"2009","journal-title":"Dev. Cell"},{"key":"2021070616261572900_DEV198192C26","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ydbio.2011.06.011","article-title":"Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin\/Mrtf-B and Fgf10 expression","volume":"356","author":"Goss","year":"2011","journal-title":"Dev Biol"},{"key":"2021070616261572900_DEV198192C27","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.stemcr.2014.07.005","article-title":"Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells","volume":"3","author":"Gotoh","year":"2014","journal-title":"Stem Cell Rep."},{"key":"2021070616261572900_DEV198192C28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fbioe.2019.00039","article-title":"Engineering organoid vascularization","volume":"7","author":"Grebenyuk","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"2021070616261572900_DEV198192C29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nbt.1788","article-title":"Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells","volume":"29","author":"Green","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"2021070616261572900_DEV198192C30","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ydbio.2017.05.005","article-title":"Osr1 functions downstream of Hedgehog pathway to regulate foregut development","volume":"427","author":"Han","year":"2017","journal-title":"Dev. Biol."},{"key":"2021070616261572900_DEV198192C31","doi-asserted-by":"publisher","first-page":"4158","DOI":"10.1038\/s41467-020-17968-x","article-title":"Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis","volume":"11","author":"Han","year":"2020","journal-title":"Nat. Commun."},{"key":"2021070616261572900_DEV198192C32","doi-asserted-by":"publisher","first-page":"16287","DOI":"10.1073\/pnas.0902274106","article-title":"\u03b2-catenin promotes respiratory progenitor identity in mouse foregut","volume":"106","author":"Harris-Johnson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021070616261572900_DEV198192C33","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1172\/JCI89950","article-title":"Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells","volume":"127","author":"Hawkins","year":"2017","journal-title":"J. Clin. Invest."},{"key":"2021070616261572900_DEV198192C34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.stem.2020.09.017","article-title":"Derivation of airway basal stem cells from human pluripotent stem cells","volume":"28","author":"Hawkins","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C35","first-page":"259","article-title":"Nose, larynx, and trachea","volume-title":"Pathology of the Mouse: Reference and Atlas","author":"Herbert","year":"1999"},{"key":"2021070616261572900_DEV198192C36","doi-asserted-by":"publisher","first-page":"19444","DOI":"10.1073\/pnas.1313223110","article-title":"Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways","volume":"110","author":"Hines","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021070616261572900_DEV198192C37","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.stem.2014.07.012","article-title":"Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function","volume":"15","author":"Hogan","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C38","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0002-9440(10)63147-1","article-title":"Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium","volume":"164","author":"Hong","year":"2004","journal-title":"Am. J. Pathol."},{"key":"2021070616261572900_DEV198192C39","doi-asserted-by":"publisher","first-page":"dev171496","DOI":"10.1242\/dev.171496","article-title":"Wnt\/Fgf crosstalk is required for the specification of basal cells in the trachea","volume":"146","author":"Hou","year":"2019","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C40","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nbt.2754","article-title":"Efficient generation of lung and airway epithelial cells from human pluripotent stem cells","volume":"32","author":"Huang","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"2021070616261572900_DEV198192C41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cell.2019.08.041","article-title":"Genetic and mechanical regulation of intestinal smooth muscle development","volume":"179","author":"Huycke","year":"2019","journal-title":"Cell"},{"key":"2021070616261572900_DEV198192C42","doi-asserted-by":"publisher","first-page":"L1116","DOI":"10.1152\/ajplung.00033.2004","article-title":"FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium","volume":"287","author":"Hyatt","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021070616261572900_DEV198192C43","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ydbio.2009.11.005","article-title":"Foregut separation and tracheo-oesophageal malformations: the role of tracheal outgrowth, dorso-ventral patterning and programmed cell death","volume":"337","author":"Ioannides","year":"2010","journal-title":"Dev. Biol."},{"key":"2021070616261572900_DEV198192C44","volume-title":"The Atlas of Mouse Development","author":"Kaufman","year":"1992"},{"key":"2021070616261572900_DEV198192C45","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.devcel.2019.11.002","article-title":"Isl1 regulation of Nkx2.1 in the early foregut epithelium is required for trachea-esophageal separation and lung lobation","volume":"51","author":"Kim","year":"2019","journal-title":"Dev. Cell"},{"key":"2021070616261572900_DEV198192C46","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1038\/s41467-018-05189-2","article-title":"Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus","volume":"9","author":"Kishimoto","year":"2018","journal-title":"Nat. Commun."},{"key":"2021070616261572900_DEV198192C47","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1038\/s41467-020-17969-w","article-title":"Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells","volume":"11","author":"Kishimoto","year":"2020","journal-title":"Nat. Commun."},{"key":"2021070616261572900_DEV198192C48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2139\/ssrn.3737813","article-title":"Airway tissue stem cells reutilize the embryonic proliferation regulator, Tgf\u03b2-Id2 axis, for tissue regeneration","volume":"56","author":"Kiyokawa","year":"2021","journal-title":"Dev. Cell"},{"key":"2021070616261572900_DEV198192C49","doi-asserted-by":"publisher","first-page":"9478","DOI":"10.1073\/pnas.1019418108","article-title":"Cholinergic chemosensory cells in the trachea regulate breathing","volume":"108","author":"Krasteva","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021070616261572900_DEV198192C50","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1242\/dev.01044","article-title":"Development of definitive endoderm from embryonic stem cells in culture","volume":"131","author":"Kubo","year":"2004","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C51","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.stem.2015.09.004","article-title":"Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells","volume":"17","author":"Kurmann","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C52","doi-asserted-by":"publisher","first-page":"e55526","DOI":"10.7554\/eLife.55526","article-title":"Delineating the early transcriptional specification of the mammalian trachea and esophagus","volume":"9","author":"Kuwahara","year":"2020","journal-title":"eLife"},{"issue":"(19)","key":"2021070616261572900_DEV198192C53","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1242\/dev.152686","article-title":"HOXA5 plays tissue-specific roles in the developing respiratory system","volume":"144","author":"Landry-Truchon","year":"2017","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C54","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1242\/dev.113.3.891","article-title":"Clonal analysis of epiblast fate during germ layer formation in the mouse embryo","volume":"113","author":"Lawson","year":"1991","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C55","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1242\/dev.113.4.1093","article-title":"The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain","volume":"113","author":"Lazzaro","year":"1991","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C56","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.jpedsurg.2009.09.005","article-title":"Tracheal cartilaginous sleeve in patients with craniosynostosis syndromes: a meta-analysis","volume":"45","author":"Lertsburapa","year":"2010","journal-title":"J. Pediatr. Surg."},{"key":"2021070616261572900_DEV198192C57","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ydbio.2008.07.021","article-title":"Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis","volume":"322","author":"Li","year":"2008","journal-title":"Dev. Biol."},{"issue":"(19)","key":"2021070616261572900_DEV198192C58","doi-asserted-by":"publisher","first-page":"E1990","DOI":"10.1073\/pnas.1323112111","article-title":"Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage","volume":"111","author":"Lin","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021070616261572900_DEV198192C59","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/1717","article-title":"Sonic hedgehog is essential to foregut development","volume":"20","author":"Litingtung","year":"1998","journal-title":"Nat. Genet."},{"key":"2021070616261572900_DEV198192C60","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1513\/pats.200801-003AW","article-title":"The glandular stem\/progenitor cell niche in airway development and repair","volume":"5","author":"Liu","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"2021070616261572900_DEV198192C61","doi-asserted-by":"publisher","first-page":"e0177899","DOI":"10.1371\/journal.pone.0177899","article-title":"Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS ONE"},{"key":"2021070616261572900_DEV198192C62","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.stem.2013.12.007","article-title":"Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations","volume":"14","author":"Loh","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C63","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.cell.2016.06.011","article-title":"Mapping the pairwise choices leading from pluripotency to human bone, heart, and other mesoderm cell types","volume":"166","author":"Loh","year":"2016","journal-title":"Cell"},{"key":"2021070616261572900_DEV198192C64","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.stem.2012.01.019","article-title":"Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells","volume":"10","author":"Longmire","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C65","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1242\/dev.128.10.1831","article-title":"Genetic dissection of nodal function in patterning the mouse embryo","volume":"128","author":"Lowe","year":"2001","journal-title":"Development"},{"issue":"(12)","key":"2021070616261572900_DEV198192C66","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1242\/dev.128.12.2397","article-title":"Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations","volume":"128","author":"Mahlapuu","year":"2001","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C67","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.stem.2017.03.001","article-title":"Efficient derivation of functional human airway epithelium from pluripotent stem cells via temporal regulation of Wnt signaling","volume":"20","author":"McCauley","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C68","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.stemcr.2018.03.013","article-title":"Single-cell transcriptomic profiling of pluripotent stem cell-derived SCGB3A2+ airway epithelium","volume":"10","author":"McCauley","year":"2018","journal-title":"Stem Cell Rep."},{"key":"2021070616261572900_DEV198192C69","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nature13863","article-title":"Modelling human development and disease in pluripotent stem-cell-derived gastric organoids","volume":"516","author":"McCracken","year":"2014","journal-title":"Nature"},{"issue":"(10)","key":"2021070616261572900_DEV198192C70","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1242\/dev.120.10.2749","article-title":"Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants","volume":"120","author":"Mendelsohn","year":"1994","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C71","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/dvdy.20105","article-title":"Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung","volume":"231","author":"Miller","year":"2004","journal-title":"Dev. Dyn."},{"key":"2021070616261572900_DEV198192C72","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1006\/dbio.1999.9234","article-title":"Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(\u2212\/\u2212) mouse embryos","volume":"209","author":"Minoo","year":"1999","journal-title":"Dev. Biol."},{"key":"2021070616261572900_DEV198192C73","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/dvdy.20256","article-title":"Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development","volume":"232","author":"Molotkov","year":"2005","journal-title":"Dev. Dyn."},{"key":"2021070616261572900_DEV198192C74","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41586-018-0393-7","article-title":"A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","volume":"560","author":"Montoro","year":"2018","journal-title":"Nature"},{"key":"2021070616261572900_DEV198192C75","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1242\/jcs.058669","article-title":"Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate","volume":"123","author":"Morimoto","year":"2010","journal-title":"J. Cell Sci."},{"key":"2021070616261572900_DEV198192C76","doi-asserted-by":"publisher","first-page":"4365","DOI":"10.1242\/dev.083840","article-title":"Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells","volume":"139","author":"Morimoto","year":"2012","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C77","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.devcel.2009.12.010","article-title":"Preparing for the first breath: genetic and cellular mechanisms in lung development","volume":"18","author":"Morrisey","year":"2010","journal-title":"Dev. Cell"},{"key":"2021070616261572900_DEV198192C78","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/1711","article-title":"Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus","volume":"20","author":"Motoyama","year":"1998","journal-title":"Nat. Genet."},{"key":"2021070616261572900_DEV198192C79","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.stem.2012.01.018","article-title":"Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs","volume":"10","author":"Mou","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C80","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.stem.2016.05.012","article-title":"Dual SMAD signaling inhibition enables long-term expansion of diverse epithelial basal cells","volume":"19","author":"Mou","year":"2016","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C81","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.stem.2017.05.020","article-title":"Differentiation of human pluripotent stem cells into colonic organoids via transient activation of BMP signaling","volume":"21","author":"M\u00fanera","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C82","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.devcel.2019.11.003","article-title":"Endosome-mediated epithelial remodeling downstream of Hedgehog-Gli is required for tracheoesophageal separation","volume":"51","author":"Nasr","year":"2019","journal-title":"Dev. Cell"},{"key":"2021070616261572900_DEV198192C83","doi-asserted-by":"publisher","first-page":"dmm046573","DOI":"10.1242\/dmm.046573","article-title":"Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes","volume":"14","author":"Nasr","year":"2021","journal-title":"Dis. Model Mech."},{"key":"2021070616261572900_DEV198192C84","doi-asserted-by":"publisher","first-page":"dev163485","DOI":"10.1242\/dev.163485","article-title":"Human lung development: recent progress and new challenges","volume":"145","author":"Nikoli\u0107","year":"2018","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C85","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1046\/j.1365-2443.2003.00662.x","article-title":"The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a\/JNK signalling pathway","volume":"8","author":"Oishi","year":"2003","journal-title":"Genes Cells"},{"key":"2021070616261572900_DEV198192C86","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1242\/dev.01678","article-title":"Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation","volume":"132","author":"Okubo","year":"2005","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C87","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/dvdy.22192","article-title":"Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage","volume":"239","author":"Park","year":"2010","journal-title":"Dev. Dyn."},{"key":"2021070616261572900_DEV198192C88","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nature12358","article-title":"Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor","volume":"500","author":"Peng","year":"2013","journal-title":"Nature,"},{"key":"2021070616261572900_DEV198192C89","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/S0960-9822(98)70446-4","article-title":"Sonic hedgehog regulates branching morphogenesis in the mammalian lung","volume":"8","author":"Pepicelli","year":"1998","journal-title":"Curr. Biol."},{"key":"2021070616261572900_DEV198192C90","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41586-018-0394-6","article-title":"A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte","volume":"560","author":"Plasschaert","year":"2018","journal-title":"Nature"},{"key":"2021070616261572900_DEV198192C91","doi-asserted-by":"publisher","first-page":"dev175059","DOI":"10.1242\/dev.175059","article-title":"The lateral plate mesoderm","volume":"147","author":"Prummel","year":"2020","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C92","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/wdev.179","article-title":"The initial establishment and epithelial morphogenesis of the esophagus: a new model of tracheal-esophageal separation and transition of simple columnar into stratified squamous epithelium in the developing esophagus","volume":"4","author":"Que","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"2021070616261572900_DEV198192C93","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/j.1432-0436.2006.00096.x","article-title":"Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps","volume":"74","author":"Que","year":"2006","journal-title":"Differentiation"},{"key":"2021070616261572900_DEV198192C94","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1242\/dev.003855","article-title":"Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm","volume":"134","author":"Que","year":"2007","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C95","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1242\/dev.034629","article-title":"Multiple roles for Sox2 in the developing and adult mouse trachea","volume":"136","author":"Que","year":"2009","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C96","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1242\/dev.015495","article-title":"Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme","volume":"135","author":"Rajagopal","year":"2008","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C97","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1242\/dev.127.12.2763","article-title":"Hedgehog signals regulate multiple aspects of gastrointestinal development","volume":"127","author":"Ramalho-Santos","year":"2000","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C98","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1002\/jcb.24810","article-title":"Gene regulatory networks governing lung specification","volume":"115","author":"Rankin","year":"2014","journal-title":"J. Cel.l Biochem."},{"key":"2021070616261572900_DEV198192C99","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.celrep.2016.05.060","article-title":"A retinoic acid-hedgehog cascade coordinates mesoderm-inducing signals and endoderm competence during lung specification","volume":"16","author":"Rankin","year":"2016","journal-title":"Cell Rep."},{"key":"2021070616261572900_DEV198192C100","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1073\/pnas.0610770104","article-title":"Lung development and repair: contribution of the ciliated lineage","volume":"104","author":"Rawlins","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021070616261572900_DEV198192C101","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C102","doi-asserted-by":"publisher","first-page":"5585","DOI":"10.1073\/pnas.052124799","article-title":"Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice","volume":"99","author":"R\u00e9gnier","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021070616261572900_DEV198192C103","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ydbio.2008.06.009","article-title":"The transmembrane protein TMEM16A is required for normal development of the murine trachea","volume":"321","author":"Rock","year":"2008","journal-title":"Dev. Biol."},{"key":"2021070616261572900_DEV198192C104","doi-asserted-by":"publisher","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021070616261572900_DEV198192C105","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1242\/dmm.006031","article-title":"Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling","volume":"3","author":"Rock","year":"2010","journal-title":"Dis. Model Mech."},{"key":"2021070616261572900_DEV198192C106","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1242\/dev.051680","article-title":"FGF10 controls the patterning of the tracheal cartilage rings via Shh","volume":"138","author":"Sala","year":"2011","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C107","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.21037\/jtd.2016.11.74","article-title":"Tracheal and bronchial stenoses and other obstructive conditions","volume":"8","author":"Schweiger","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"2021070616261572900_DEV198192C108","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/5096","article-title":"Fgf10 is essential for limb and lung formation","volume":"21","author":"Sekine","year":"1999","journal-title":"Nat. Genet."},{"key":"2021070616261572900_DEV198192C109","doi-asserted-by":"publisher","first-page":"10738","DOI":"10.1074\/jbc.275.15.10738","article-title":"SOX9 enhances aggrecan gene promoter\/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6","volume":"275","author":"Sekiya","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021070616261572900_DEV198192C110","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1242\/dev.01570","article-title":"Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung","volume":"132","author":"Serls","year":"2005","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C111","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1242\/dev.150193","article-title":"Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification","volume":"144","author":"Serra","year":"2017","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C112","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1164\/rccm.201809-1626OC","article-title":"Complete tracheal ring deformity. a translational genomics approach to pathogenesis","volume":"200","author":"Sinner","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021070616261572900_DEV198192C113","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ydbio.2015.06.009","article-title":"Endodermal Wnt signaling is required for tracheal cartilage formation","volume":"405","author":"Snowball","year":"2015","journal-title":"Dev. Biol."},{"key":"2021070616261572900_DEV198192C114","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1183\/09031936.94.07081416","article-title":"Foetal airway motor tone in prenatal lung development of the pig","volume":"7","author":"Sparrow","year":"1994","journal-title":"Eur. Respir. J."},{"key":"2021070616261572900_DEV198192C115","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature09691","article-title":"Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro","volume":"470","author":"Spence","year":"2011","journal-title":"Nature"},{"key":"2021070616261572900_DEV198192C116","volume-title":"Gray's Anatomy: The Anatomical Basis of Clinical Practice","author":"Standring","year":"2005"},{"key":"2021070616261572900_DEV198192C117","doi-asserted-by":"publisher","first-page":"E10615","DOI":"10.1073\/pnas.1811624115","article-title":"Evolutionarily conserved Tbx5-Wnt2\/2b pathway orchestrates cardiopulmonary development","volume":"115","author":"Steimle","year":"2018","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"2021070616261572900_DEV198192C118","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1146\/annurev-cellbio-100814-125249","article-title":"Lung endoderm morphogenesis: gasping for form and function","volume":"31","author":"Swarr","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2021070616261572900_DEV198192C119","doi-asserted-by":"publisher","first-page":"E3641","DOI":"10.1073\/pnas.1409781111","article-title":"IL-6\/STAT3 promotes regeneration of airway ciliated cells from basal stem cells","volume":"111","author":"Tadokoro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021070616261572900_DEV198192C120","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1126\/science.aaw7567","article-title":"Organoids by design","volume":"364","author":"Takebe","year":"2019","journal-title":"Science"},{"key":"2021070616261572900_DEV198192C121","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nrg2084","article-title":"Gene function in mouse embryogenesis: get set for gastrulation","volume":"8","author":"Tam","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"2021070616261572900_DEV198192C122","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1126\/science.1204831","article-title":"Control of mitotic spindle angle by the RAS-regulated ERK1\/2 pathway determines lung tube shape","volume":"333","author":"Tang","year":"2011","journal-title":"Science"},{"key":"2021070616261572900_DEV198192C123","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.devcel.2017.12.013","article-title":"Mechanical forces program the orientation of cell division during airway tube morphogenesis","volume":"44","author":"Tang","year":"2018","journal-title":"Dev. Cell"},{"key":"2021070616261572900_DEV198192C124","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature12777","article-title":"Dedifferentiation of committed epithelial cells into stem cells in vivo","volume":"503","author":"Tata","year":"2013","journal-title":"Nature"},{"key":"2021070616261572900_DEV198192C125","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.stem.2018.03.018","article-title":"Myoepithelial cells of submucosal glands can function as reserve stem cells to regenerate airways after injury","volume":"22","author":"Tata","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C126","doi-asserted-by":"publisher","first-page":"bio048728","DOI":"10.1242\/bio.048728","article-title":"The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components","volume":"9","author":"Teramoto","year":"2020","journal-title":"Biol Open"},{"key":"2021070616261572900_DEV198192C127","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1203\/PDR.0b013e3181b45580","article-title":"Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome","volume":"66","author":"Tiozzo","year":"2009","journal-title":"Pediatr Res"},{"key":"2021070616261572900_DEV198192C128","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/dvdy.1124","article-title":"Spatial and temporal distribution of nerves, ganglia, and smooth muscle during the early pseudoglandular stage of fetal mouse lung development","volume":"221","author":"Tollet","year":"2001","journal-title":"Dev. Dyn."},{"key":"2021070616261572900_DEV198192C129","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.stem.2018.08.008","article-title":"Esophageal organoids from human pluripotent stem cells delineate Sox2 functions during esophageal specification","volume":"23","author":"Trisno","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C130","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1242\/dev.034884","article-title":"Notch signaling controls the balance of ciliated and secretory cell fates in developing airways","volume":"136","author":"Tsao","year":"2009","journal-title":"Development"},{"key":"2021070616261572900_DEV198192C131","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1741-7007-11-117","article-title":"Lung mesenchymal expression of Sox9 plays a critical role in tracheal development","volume":"11","author":"Turcatel","year":"2013","journal-title":"BMC Biol."},{"key":"2021070616261572900_DEV198192C132","doi-asserted-by":"publisher","first-page":"L196","DOI":"10.1152\/ajplung.00127.2016","article-title":"Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes","volume":"312","author":"Turcatel","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021070616261572900_DEV198192C133","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ydbio.2018.08.011","article-title":"FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme","volume":"443","author":"Ustiyan","year":"2018","journal-title":"Dev. Biol."},{"issue":"(25)","key":"2021070616261572900_DEV198192C134","doi-asserted-by":"publisher","first-page":"22743","DOI":"10.1074\/jbc.M202253200","article-title":"Fibroblast growth factor 18 influences proximal programming during lung morphogenesis","volume":"277","author":"Whitsett","year":"2002","journal-title":"J Biol Chem"},{"key":"2021070616261572900_DEV198192C135","doi-asserted-by":"publisher","first-page":"e22493","DOI":"10.1371\/journal.pone.0022493","article-title":"Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation","volume":"6","author":"Woo","year":"2011","journal-title":"PLoS One"},{"key":"2021070616261572900_DEV198192C136","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nm.4233","article-title":"Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system","volume":"23","author":"Workman","year":"2017","journal-title":"Nat. Med."},{"key":"2021070616261572900_DEV198192C137","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nature02418","article-title":"Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo","volume":"428","author":"Yamamoto","year":"2004","journal-title":"Nature"},{"key":"2021070616261572900_DEV198192C138","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.stem.2018.03.016","article-title":"Human pluripotent stem cell-derived endoderm for modeling development and clinical applications","volume":"22","author":"Yiangou","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2021070616261572900_DEV198192C139","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1038\/s41467-018-05043-5","article-title":"The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis","volume":"9","author":"Yin","year":"2018","journal-title":"Nat. Commun."},{"key":"2021070616261572900_DEV198192C140","doi-asserted-by":"publisher","first-page":"1800840","DOI":"10.1183\/13993003.00840-2018","article-title":"Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis","volume":"53","author":"Yin","year":"2019","journal-title":"Eur. Respir. J."},{"key":"2021070616261572900_DEV198192C141","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/jcb.20211","article-title":"Multiple functions of BMPs in chondrogenesis","volume":"93","author":"Yoon","year":"2004","journal-title":"J. Cell Biochem."},{"key":"2021070616261572900_DEV198192C142","doi-asserted-by":"publisher","first-page":"585640","DOI":"10.3389\/fcell.2020.585640","article-title":"Incoherent feedforward regulation via Sox9 and ERK underpins mouse tracheal cartilage development","volume":"8","author":"Yoshida","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"2021070616261572900_DEV198192C143","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.devcel.2020.02.001","article-title":"Smooth muscle differentiation is essential for airway size, tracheal cartilage segmentation, but dispensable for epithelial branching","volume":"53","author":"Young","year":"2020","journal-title":"Dev. Cell"},{"key":"2021070616261572900_DEV198192C144","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev.cellbio.042308.113344","article-title":"Vertebrate endoderm development and organ formation","volume":"25","author":"Zorn","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.198192\/2087737\/dev198192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.198192\/2087737\/dev198192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T16:26:48Z","timestamp":1625588808000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/148\/13\/dev198192\/270821\/Mammalian-tracheal-development-and-reconstruction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":144,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.198192","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]},"article-number":"dev198192"}}