{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:19:24Z","timestamp":1783761564059,"version":"3.55.0"},"reference-count":51,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"European Research Council","award":["677809"],"award-info":[{"award-number":["677809"]}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"crossref","award":["266869"],"award-info":[{"award-number":["266869"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"crossref","award":["KAW 2014.0207"],"award-info":[{"award-number":["KAW 2014.0207"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Finnish Cancer Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epithelial attachment to the basement membrane (BM) is essential for mammary gland development, yet the exact roles of specific BM components remain unclear. Here, we show that Laminin \u03b15 (Lama5) expression specifically in the luminal epithelial cells is necessary for normal mammary gland growth during puberty, and for alveologenesis during pregnancy. Lama5 loss in the keratin 8-expressing cells results in reduced frequency and differentiation of hormone receptor expressing (HR+) luminal cells. Consequently, Wnt4-mediated crosstalk between HR+ luminal cells and basal epithelial cells is compromised during gland remodeling, and results in defective epithelial growth. The effects of Lama5 deletion on gland growth and branching can be rescued by Wnt4 supplementation in the in vitro model of branching morphogenesis. Our results reveal a surprising role for BM-protein expression in the luminal mammary epithelial cells, and highlight the function of Lama5 in mammary gland remodeling and luminal differentiation.<\/jats:p>","DOI":"10.1242\/dev.199281","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T08:53:24Z","timestamp":1623747204000},"source":"Crossref","is-referenced-by-count":24,"title":["Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-6843","authenticated-orcid":false,"given":"Johanna I.","family":"Englund","sequence":"first","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Sciences (HiLIFE), 00014 University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Sciences (HiLIFE), 00014 University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-697X","authenticated-orcid":false,"given":"Leander","family":"Blaas","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Cojoc","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Sciences (HiLIFE), 00014 University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-1073","authenticated-orcid":false,"given":"Nalle","family":"Pentinmikko","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Sciences (HiLIFE), 00014 University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"D\u00f6hla","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Sciences (HiLIFE), 00014 University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharif","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Sciences (HiLIFE), 00014 University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Patarroyo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 11 Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3033-4189","authenticated-orcid":false,"given":"Pekka","family":"Katajisto","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Helsinki Institute of Life Sciences (HiLIFE), 00014 University of Helsinki, Helsinki, Finland"},{"name":"Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden"},{"name":"Faculty of Biological and Environmental Sciences, 00014 University of Helsinki, Helsinki, Finland"},{"name":"Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"2021061512531747600_DEV199281C1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/bcr1286","article-title":"Myoepithelial cells: good fences make good neighbors","volume":"7","author":"Adriance","year":"2005","journal-title":"Breast Cancer Res."},{"key":"2021061512531747600_DEV199281C2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s40778-016-0056-2","article-title":"Extracellular matrix regulation of stem cell behavior","volume":"2","author":"Ahmed","year":"2016","journal-title":"Curr Stem Cell Rep"},{"key":"2021061512531747600_DEV199281C3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ncb2646","article-title":"An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium","volume":"15","author":"Akhtar","year":"2013","journal-title":"Nat. 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